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DEEP BRAIN STIMULATION FOR THE TREATMENT OF INVOLUNTARY MOVEMENT DISORDERS

Research Project

Project/Area Number 09470302
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNIHON UNIVERSITY

Principal Investigator

KATAYAMA Yoichi  SCHOOL OF ENGINEERING,NIHON UNIVERSITY,PROFESSOR, 医学部, 教授 (00125048)

Co-Investigator(Kenkyū-buntansha) HIRAYAMA Heruyasu  SCHOOL OF MEDICINE,NIHON UNIVERSITY,ASSISTANT PROF., 医学部, 講師 (10189871)
YAMAMOTO Takamitsu  SCHOOL OF MEDICINE,NIHON UNIVERSITY,ASSOCIATE PROF., 医学部, 助教授 (50158284)
SEKINE Yosifumi  SCHOOL OF ENGINEERING,NIHON UNIVERSITY,PROFESSOR, 理工学部, 教授 (90059965)
KOSHINAGA Morimichi  SCHOOL OF MEDICINE,NIHON UNIVERSITY,INSTRUCTOR, 医学部, 助手 (30267067)
KAWAMATA Tatsuro  SCHOOL OF MEDICINE,NIHON UNIVERSITY,INSTRUCTOR, 医学部, 助手 (20234122)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥10,600,000 (Direct Cost: ¥10,600,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥9,400,000 (Direct Cost: ¥9,400,000)
KeywordsGLOBUS PALLIDUS / INVOLUNTARY MOVEMENT / PARKINSON'S DISEASE / SUBTHALAMIC NUCLEUS
Research Abstract

We studied about the effects of chronic deep brain stimulation for the treatment of involuntary movement disorders, and the results of a double blinded evaluation of the effects of globus pallidus (Gpi; n = 7) and subthalamic nucleus (STN; n = 11) stimulation in patients with advanced Parkinson's disease are summarized in this report. The patients were evaluated at 6-8 months after surgery. In order to determine the benefits afforded by the stimulation to the actual daily activities, the patients were maintained on-medication with optimal doses and schedules. The stimulation was turned off overnight for at least 12 hours. It was turned on in the morning (or maintained turned off), and the best and worst scores during daytime actibity were recorded, as on-period and off-period scores, respectively. A reduction in total motor score on the Unified Parkinson's Disease Rating Scale was clearly elicited by Gpi and STN stimulation at both the off-period (-57% and -29%, respectively) and the on-period (-36% and -25%, respectively). The difference in effects between Gpi and STN stimulation appeared to be due largely to an unintended difference in the patients preoperative symptoms. The benefits provided by stimulation to the actual daily activities appears to be limited in patients who have become unresponsive to a large dose of levodopa. Two advantages of Gpi and STN stimulation were identified. The stimulation can supplement a reduced action of levodopa during the off-period. Secondary, the stimulation can replace part of the action of levodopa during the on-period. More importantly, the stimulation improves the daily activities in dopa-intolerant patients who are being administered a small dose of levodopa because of unbearable side effects.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Yamamoto T.: "Pharmacological classification of central post-stroke pain : comparison with the results of chronic motor wrtex stimulation"Pain. 72. 5-12 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katayama Y.: "Control of post-stroke involuntary and voluntary movement disorders with deep brain or epidural cortical stimulation"Steveotactic and Functional Neurosurgery. 69. 73-79 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katayama Y.: "Post-stroke pain control by chronic motor cortex stimulation Neurological characteristics predicting favorable response"Journal of Neurosurgery. 89. 585-591 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fukaya c.: "Changes in event-related cerebral potentials(P3a)in patients with lesions of the pontomesencephalic Junction"Electroencephalograph and Clinical Neurophysiclogy. 49. 204-209 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakatani K.: "Cerebral blood oxygenation changes of the frontal lobe induced by divert electrical stimulation of thalamic and globus pallidus."J of Neurology Neurosurgery and Psychiatry. 67. 769-773 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tsubokawa T.: "Lesion-making surgery versus brain stimulation for treatment of Parkinson's disease."Critical Review of Neurosurgevy. 9. 96-106 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katayama Y.: "Effects of on tevodorsal pallidal stimulation of gait freezing(kinesia paradoxa)in Parkinson's disease"Steveotact Funct Neurosury. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katayama Y.: "Double blinded evaluation of the effects of pallidal and subthalamic stimulation on daytime activity in advanced parkinson's disease"Parkinsonism & Related Disorders. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yamamoto T, Katayama Y, Hirayama T, Fukaya C: "Pharmacological classification of central post-stroke painf : comparison with the results of chronic motor cortex stimulation."Pain. 72. 5-12 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katayama Y, Fukaya C, Yamanoto T: "Control of post-stroke involuntary and voluntary movement disorders with deep brain or epidural cortical stimulation."Stereotactic and functiona Neurosurgery. 69. 73-79 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katayama Y, Fukaya C, Yamamoto T: "Post-stroke pain control by chronic motor cortex stimulation : Neurological characleristics predicting favorable response."Journal of Neurosurgery. 89. 585-591 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fukaya C, Katayama Y, Kasai M, Kurihara J, Yamamoto T: "Intraoperative monitoring of oculomotor nerve function for skull base surgery using electro-oculography."Journal of Neurosurgery. 91. 157-159 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fukaya C, Katayama Y, Kurihara J: "Changes in event-related cerebral potentials (P3a) in patients with lesions of the pontomesencephalic junction."Electroencephalography and Clinical Neurophysiology (Suppl). 49. 204-209 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakatani K, Kayayama Y, Yamamoto T, Suzuki S: "Cerebral blood oxygenation changes of the frontal lobe induced by clirect electrical stimulation of thalamic and globus pallidus. A near infrared spectroscopy study."Journal of Neurology Neurosurgery and Psychiatry. 67. 769-773 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tsubokawa T, Katayama Y: "Lesion-making surgery versus brain stimulation for treatment of Parkinson's discase."Critical Review of Neurosurgery. 9. 96-106 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katayama Y, Kasai M, Ohshima H, Fukaya C, Yamamoto T: "Effects of anterodorsal pallidal stimulation on gait freezing (kinesia paradoxa) in parkinson's disease."Stereotact Funct Neurosurg. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katayama Y, Kasai M, Ohshima H, Fukaya C, Yamamoto T, Mizutani T: "Double blinded evaluation of the effects of pallidal and subthalamic nucleus stimulation on daytime activity in advanced parkinson's disease."Parkinsonism & Related Disourders. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katayama Y.et al: "Posr-stroke pain control by chronic motor cortex stimulation"Journal of Neurosurgery. 89. 585-591 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fukay C.et al: "Intraoperative monitoring of oculomotor nerve function skull base surgery using electro-oculography"Journal of Neurosurgery. 91. 157-159 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sakatani K.et al: "Cerebral blood oxygen changes of the trontal lobe induced by direct stimulation of thalamus and globus pallidus"Journal of Neurology Neurosurgery and Dsychiatry. 67. 769-773 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tsubokawa T.et al: "Lesion-making surgery versus brain stimulation for treatment of Parkinson's disease"Critical Review of Neurosurgery. 9. 96-106 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 片山容一: "パーキンソン病の脳深部刺激療法" 医学のあゆみ. 186. 116-119 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 片山容一: "Poststroke pain control by chronic motor cortex stimulation neurotogicue caracteristics predictinra a favorable response." J.Neurosurgery. 89. 585-591 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 片山容一: "定位脳手術" 片山,板倉,大木,大江,編著, 401 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takamitsu Yamamoto et al: "Pharmacological classitication of central post-stroke pain ; comparison with the results of chronic motor cortex stimulation therapy" Pain. 72. 5-12 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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