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Study of the mechanism of lung vascular permeability in pulmonary edema

Research Project

Project/Area Number 09470325
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNAGOYA UNIVERSITY

Principal Investigator

SHIMADA Yasuhiro  Nagoya University, School of Medicine, Professor, 医学部, 教授 (50028669)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Yoshihiro  Nagoya University, School of Medicine, Research Associate, 医学部, 助手 (70238640)
ISHIKAWA Naohisa  Aichi Medical College, Professor, 教授 (80109321)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥14,600,000 (Direct Cost: ¥14,600,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1998: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1997: ¥8,300,000 (Direct Cost: ¥8,300,000)
Keywordsneurogenic pulmonary edema / lung / vascular permeability / central nervous system / pulmonary edema / neuropeptide Y / sympathetic nervous system / nitric oxide / 血管透過性亢進 / 神経伝達物質 / ARDS / neropeptide Y / neuropepetides / 肺循環
Research Abstract

A variety of chemical mediators has been known to be responsible for the development of permeability pulmonary edema. We have been investigating the mechanisms of neurogenic pulmonary edema by using a rat model in which fibrinogen and thrombin are injected into the cisterna magna (neurogenic pulmonary edema model), and have found that neuropeptide Y (NPY) and neurokinin A, simultaneously released from the sympathetic nerve terminal, increase pulmonary vascular permeability. In terms of NPY, we reported a pioneer work in which NPY is proved to be one of the permeability substances by using an isolated perfused lung model and stimulating the sympathetic nerve. We also clarified that NPY administered intratracheally increases lung vascular permeability dose-despondently in the same model. In the following study, we have found that NPY is present both in the edema fluid and in alveolar macrophages and the concentration is 1000 times higher than that found in plasma by using an immunohistochemical method.
In the present study, we have meticulously studied the effect of nitric oxide (NO) on the development of pulmonary edema. The present results may suggest that the mechanism of neurogenic pulmonary edema is peripherally related to the release of chemical mediators such as NPY from the sympathetic nerve terminal, and centrally related to NO in the central nervous system. Also in a preliminary study of rats in which the vagus nerve was severed several days before, neurogenic pulmonary edema was completely avoided. Although the precise mechanism is still not clear, the development of neurogenic pulmonary edema may be closely related to the effects of NO in the central nervous system and NPY in the peripheral sympathetic nerve terminal.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (50 results)

All Other

All Publications (50 results)

  • [Publications] 西脇公俊: "Neuropeptide-(18-36) may prevent neurogenic pulmonary edema in rats"11th World Congress of Anaesthesiologists, Abstract Book. 240. (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 山下明子: "Effects of neuropeptide Y on pulmonary vascular permeability and its receptor"11th World Congress of Anaesthesiologists, Abstract Book. 246. (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 平林明子: "Role of neuropeptide Y and its receptor subtype in the neurogenic pulmonary edema"European Journal of Pharmacology. 196. 297-305 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石川直久: "Complete nucleotide sequence and genetic organization of Aichi virus"J. Virology. 72. 8408-8412 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石川直久: "Epidemiologic study of Shigella sonnei from sequential outbreaks and sporadic cases using different typing techniques"Microbiol. Immunol.. 42. 259-264 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石川直久: "Contribution of cytosolic ionic and energetic milieu changes to ischemia- and reperfusion-induced injury in guinea pig heart"J. Cardiovascular Pharmacol.. 31. 146-156 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 島田康弘: "Use of medical simulators subject of international study"Journal of Clinical Monitoring and Computing. 14(7-8). 499-503 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石川直久: "Streptococcal pyogenic exotoxin F (SpeF) causes permeabilization of lung blood vessels"Infection and Immunity. 67. 4307-4311 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 近藤博子: "Association of anesthesia technique with blood loss and transfusion rates in patients with gynecological hysterectomy"Anaesthesia and Resuscitation. 35. 49-54 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 木村智政: "Heart rate and blood pressure power spectral analysis during calcium channel blocker induced hypotension"Can J Anesth. 46. 1110-1116 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 藤原祥裕: "Transfer function analysis of the circulation in patients undergoing sevoflurane anesthesia"Can J Anesth. 46. 820-825 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hamdy OM.: "Presence and quantification of neuropeptide Y in pulmonary edema fluid in rats"Experimental Lung Research. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishiwaki, K: "Neuropeptide-(18-36) may prevent neurogenic pulmonary edema in rats"11th World Congress of Anaesthesiologists, Abstract Book. 240. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yamashita, A: "Effects of neuropeptide Y on pulmonary vascular permeability and its receptor subtype in rats"11th World Congress of Anaesthesiologists, Abstract Book. 246. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hirabayashi, A: "Role of neuropeptide Y and its receptor subtype in the neurogenic pulmonary edema"European Journal of Phamacology. 196. 297-305 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishikawa, N: "Complete nucleotide sequence and genetic organization of Aichi virus, a distinct member of the picomaviriae associated with acute gastroenteritis in humans"Journal of Virology. 72. 8408-8412 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishikawa, N: "Epidemiologic study of Shigella sonnei from sequential outbreaks and sporadic cases using different typing techniques"Microbiology and Immunology. 42. 259-264 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishikawa, N: "Contribution of cytosolic ionic and energetic milieu changes to ischemia- and reperfusion-induced injury in guinea pig heart : fluorometry and nuclear magnetic resonance studies"Journal of Cardiovascular Pharmacology. 31. 146-156 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shimada, Y: "Use of medical simulators subject of international study"Journal of Clinical Monitoring and Computing. 14(7-8). 499-503 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishikawa, N: "Streptococcal pyogenic exotoxin F (SpeF) causes permeabilization of lung blood vessels"Infection and Immunity. 67. 4307-4311 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kondo, H: "Association of anesthesia technique with blood loss and transfusion rates in patients with gynecological hysterectomy"Anaesthesia and Resuscitation. 35. 49-54 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kimura, T: "Heart rate and blood pressure power spectral analysis during calcium channel blocker induced hypotension"Canadian Journal of Anesthesia. 46. 1110-1116 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujiwara, Y: "Transfer function analysis of the circulation in patients undergoing sevoflurane anesthesia"Canadian Journal of Anesthesia. 46. 820-825 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hamdy, OM: "Presence and quantification of neuropeptide Y in pulmonary edema fluid in rats"Experimental Lung Research. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 島田康弘: "Use of medical simulators subject of international study."J Clin Monit Comput. 14(7・8). 499-503 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 島田康弘: "Association of anesthesia technique with blood loss and transfusion rates in patients with gynecological hysterectomy:"Anaesth Rescus. 35. 49-54 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 島田康弘: "Heart rate and blood pressure power spectral analysis during calcium channel blocker induced hypotension."Can J Anesth. 46. 1110-1116 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 島田康弘: "Unilateral pulmonary cystic enlargement in a newborn: remember the one sided blind intubation."Paediatr Anaesth. 10. 111-113 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 藤原祥裕: "Transfer function analysis of the circulation in patients undergoing sevoflurane anesthesia."Can J Anesth. 46. 820-826 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 石川直久: "Presence and quantification of neuropeptide Y in pulmonary edema fluid in rats"Experimental Lung Research. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] 石川直久: "Streptococcal pyogenic exotoxin F (SepF) causes permeabilization of lung blood vessels"Infection and Immunity. 67. 4307-4311 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 石川直久: "A new-born baby outbreak of echovirus type 33 infection."J.of Infection. 37. 123-126 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 石川直久: "Complete nucleotide sequence and genetic organization of Aichi virus"J.Virology. 72. 8408-8412 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 石川直久: "Epidemiologic study of Shigella sonnei from sequential outbreaks and sporadic cases using different typing techniques."Microbiol.Immunol.. 42. 259-264 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 石川直久: "Contribution of cytosolic ionic and energetic milieu changes to ischemia- and reperfusion-induced injury in guinea pig heart"J.Cardiovascular Pharmacol.. 31. 146-156 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 石川直久: "Complete nucleotide sequence and genetic organization of Aichi virus,a distinct member of the picornaviriae associated with acute gastroenteritis in humans." J.Virology. 72. 8408-8412 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 石川直久: "Epidemiologic study of Shigella sonnei from sequential outbreaks and sporadic cases using different typing techniques." Microbiol.Immunol.42. 259-264 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 石川直久: "Contribution of cytosolic ionic and energetic milieu changes to ischemia-and reperfusion-induced injury in guinea pig heart:fluorometry and nuclear magnetic resonance studies." J.Cardiovascular Pharmacol.31. 146-156 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 島田康弘: "Use of medical simulators subject of international study" APSF Newsletter. 13. 8-10 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 木村智政: "ニューロパシックペインに対するケタミン麻酔量投与後の鎮痛効果" 末梢神経. 8. 81-85 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 木村智政: "ニューロパシックペイン患者における自律神経機能評価。特にアンジオテンシン変換酵素遺伝子多型性からみて。" ペインクリニック. 20. 27-31 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] NISHIWAKI Kimitoshi: "Effects of vasodilators on fibrin-induced pulmonary edema, so-called neurogenic pulmonary edema, in rat." Journal of Anesthesia. 8. 208-212 (1994)

    • Related Report
      1997 Annual Research Report
  • [Publications] SHIMADA Yasuhiro: "Monitoring of blood gases and pulmonary ventilation." Current Opinions in Anesthesiology. 7. 503-507 (1994)

    • Related Report
      1997 Annual Research Report
  • [Publications] HIRABAYAHSI Akiko: "Effects of neuropeptide Y on lung vascular permeability in the pulmonary circulation of rats." European Journal of Pharmacology. 256. 227-230 (1994)

    • Related Report
      1997 Annual Research Report
  • [Publications] 石川直久: "神経原性肺水腫における血管透過性亢進の病態生理" 日本病態生理学会雑誌. 3(2). 28- (1994)

    • Related Report
      1997 Annual Research Report
  • [Publications] NISHIWAKI Kimitoshi: "Neuropeptide-(18-36)may prevent neurogenic pulmonary edemain rats." 11th World Congress of Anaesthesiologists, Abstract Book. 240- (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 西脇公俊: "肺血管透過性への神経ペプチドの影響-Neuropeptide(NPY)の促進-Calcitonin gene related peptide(CGRP)の抑制効果" 日本集中治療医学会雑誌. 3. S127- (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 島田康弘: "術後肺炎の対策" 日本医事新報. 3759. 24-28 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] YAMASHITA Akiko: "Effects of neuropeptide Y on pulmonary vascular permeability and its receptor subtype in rats." 11th World Congress of Anaesthesiologists, Abstract Book. 246- (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] HIRABAYASHI Akiko: "Role of neuropeptide Y and its receptor subtype in the neurogenic pulmonary edema." European Journal of Pharmacology. 296. 297-305 (1996)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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