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Mechanisms of direct actions of perioperative drugs on splachnic resistance vessels

Research Project

Project/Area Number 09470330
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

AKATA Takashi  KYUSHU UNIVERSITY, Faculty of Medicine, Lecturer, 医学部・附属病院, 講師 (10260382)

Co-Investigator(Kenkyū-buntansha) KANNA Tomoo  KYUSHU UNIVERSITY, Faculty of Medicine, Assistant, 大学院・医学研究院, 助手 (00274465)
NAKASHIMA Mikio  KYUSHU UNIVERSITY, Saga Medical School, Associate Prof., 助教授 (80159061)
Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥8,800,000 (Direct Cost: ¥8,800,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥6,900,000 (Direct Cost: ¥6,900,000)
KeywordsVolatile anesthetics / Vascular smooth muscle / Vascular endothelium / Intracellular caclium stores / Resistance vessels / Fura-2 / Ketamine / Mesenteric arteries / Fura2 / 吸入麻酔薬 / 細胞内カルシュウム濃度 / Fura-2 / 細胞内カルシウム濃度
Research Abstract

Isoflurane and sevoflurane, volatile anesthetics now commonly used in Japan, at clinically relevant concentrations significantly influence contractile response to norepinephrine (NE), a sympathetic neurotransmitter, in isolated mesenteric resistance arteries. The action of these anesthetics on contractile response to NE consists of endothelium-dependent vasoconstricting and endothelium-independent vasodilating components. In the presence of endothelium, the former predominates over the latter, enhancing the NE response, while in the absence of endothelium, only the latter emerges, inhibiting the NE response. Nitric oxide, endothelium-derived hyperpolarizing factor, cyclooxygenase products, lipoxygenase products, endothelin-1, angiotensin II, or serotonin are not involved in their vasoconstricting action. Isoflurane may stimulate release of superoxide anions from endothelial cells, thereby enhancing the NE response.
Sevoflurane appears to inhibit vascular smooth muscle contraction by bot … More h reducing the intracellular Ca^<2+> concentration ([Ca^<2+>]i) and inhibiting myofilament Ca^<2+> sensitivity. The [Ca^<2+>]i-reducing effect is mainly caused by inhibition of voltage-gated Ca^<2+> influx, while its inhibitory action on myofilament Ca^<2+> sensitivity seems to require an intact cell membrane. Four volatile anesthetics halothane, isolfurane, enflurane and sevoflurane have differential effects on various functions of intracellular calcium stores of mesenteric resistance arterial smooth muscle cells such as the amount of stored Ca^<2+>, Ca^<2+> uptake, or Ca^<2+>-releasing mechanisms. These anesthetics may significantly influence vascular tone or reactivity of mesenteric resistance arteries through their various effects on the intracellular calcium stores.
Mechanisms of the action of ketamine, an intravenous anesthetic, on isolated mesenteric resistance arteries were also investigated and reported. The effects of various halogenated volatile anesthetics on isolated hepatic and renal arteries are currently under investigation. Less

Report

(5 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (86 results)

All Other

All Publications (86 results)

  • [Publications] Akata T,Boyle III WA: "Is guanosine-5'-triphophate involved in calcium-activation of contractile proteins in vascular smooth muscle?"Jpn J Pharmacol. 75(1). 1-12 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K,Akata T,Takahashi S: "The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteries. Part I : role of endothelium."Anesthesiology. 92(5). 1426-1440 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T,Izumi K,Nakashima M: "The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteries. Part II : mechanisms of endothelium-independent vasorelaxation."Anesthesiology. 92(5). 1441-1453 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T,Nakashima M,Izumi K: "Comparison of volatile anesthetic actions on intracellular calcium stores of vascular smooth muscle-Investigation in isolated systemic resistance arteries-"Anesthesiology . (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T,Izumi K,Nakashima M: "Mechanisms of direct inhibitory action of ketamine on vascular smooth muscle in mesenteric resistance arteries."Anesthesiology. (accepted January3,2001).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K,Akata T,Takahashi S: "Role of endothelium in the action of isoflurane on vascular smooth muscle of isolated mesenteric resistance arteries."Anesthesiology. (accepted February8,2001).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 赤田隆: "揮発性吸入麻酔薬が内臓抵抗血管に及ぼす直接作用とその機序に関する研究"臨床研究奨励基金年報. 2-10 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 赤田隆,泉薫: "吸入麻酔薬の血管への作用 -特にハロゲン化炭化水素型揮発性吸入麻酔薬が血管平滑筋あるいは血管内皮に及ぼす直接作用に注目して-"循環制御. 21(1). 61-83 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T et al.: "Differential effects of volatile anesthetics on intracellular calcium stores of vascular smooth muscle."Anesthesiology. 87(3A):. A514 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T,Boyle III WA: "Is activation of G-proteins involved in calcium-activation of contractile proteins in vascular smooth muscle?"Anesthesiology. 87(3A):. A603 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K,Akata T,Takahashi S: "Mechanisms of sevoflurane-induced reduction of the cytosolic free calcium concentration in vascular smooth muscle."Anesthesiology. 89(3A):. A600 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K,Akata T,Takahashi S: "Endothelium-dependent vasoconstricting action of sevoflurane in the rat mesenteric resistance artery."Anesthesiology. 89(3A):. A677 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T,Izumi K.: "Effects of sevoflurane on calcium sensitivity of the contractile apparatus in vascular smooth muscle."Anesthesiology. 91(3A):. A632 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K,Akata T,Takahashi S: "Persistent vascular hyporesponsiveness to norepinephrine after washout of sevoflurane in isolated rat mesenteric resistance arteries."Anesthesiology. 91(3A):. A649 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K,Akata T,Takahashi S: "Which endothelium-derived vasoactive mediator is involved in the endothelium-dependent vasoconstricting action of sevoflurane?"Anesthesiology. 91(3A):. A645 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kanna T,Akata T et al.: "Sevoflurane stimulates transmembrane calcium influx in pulmonary arterial valvular endothelial cells in situ."Anesthesiology. 91(3A):. A658 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K,Akata T,Takahashi S: "The action of isoflurane on vascular smooth muscle of isolated mesenteric arteries"Anesthesiology. 93(3A):. A604 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T,Nakashima M,Izumi K: "Effects of four inhaled anesthetics on intracellular calcium stores of vascular smooth muscle in small mesenteric arteries."Anesthesiology. 93(3A):. A594 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T,Izumi K,Nakashima M: "Effects of ketamine on vascular smooth muscle of rat mesenteric arteries."Anesthesiology. 93(3A):. A595 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T,Izumi K et al.: "Mechanisms of inhibitory actions of inhalational anesthetics on high K+-induced contraction in splanchnic resistance arteries."Jpn J Pharmacol. 73(suppl.-I):. 202 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 泉薫,赤田隆,高橋成輔: "内臓抵抗血管平滑筋に対する揮発性吸入麻酔薬の効果"J Anesth. 11(suppl.):. 310 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 赤田隆,泉薫,高橋成輔: "摘出内臓抵抗血管平滑筋に対する揮発性吸入麻酔薬のKCl収縮抑制作用のメカニズム"J Anesth. 11(suppl.):. 313 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 赤田隆,泉薫,高橋成輔: "血管平滑筋細胞内Ca2+貯蔵部位に対する4つの揮発性吸入麻酔薬の効果"J Anesth. 12(suppl.):. 577 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 泉薫,赤田隆,高橋成輔: "摘出内臓抵抗血管平滑筋に対するセボフルランの効果"J Anesth. 12(suppl.):. 153 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 赤田隆,漢那朝雄 et al.: "セボフルランによる肺動脈弁内皮細胞内Ca^<2+>濃度上昇作用のメカニズム"循環制御. 20(suppl.):. 49 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 赤田隆,泉薫: "摘出腸間膜小動脈におけるセボフルランの血管平滑筋直接抑制作用のメカニズム"J Anesth. 13(suppl.):. 154 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 泉薫,赤田隆,高橋成輔: "摘出腸間膜動脈におけるセボフルランの内皮依存性NE収縮反応増強作用の機序"J Anesth. 13(suppl.):. 347 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 漢那朝雄,泉薫 et al.: "摘出ラット肺動脈弁内皮細胞内カルシウム濃度に及ぼすセボフルランの効果"J Anesth. 13(suppl.):. 347 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 赤田隆,泉薫,中島幹夫: "各種揮発性吸入麻酔薬が血管平滑筋細胞内カルシウム貯蔵部位に及ぼす作用"J Anesth. 14(suppl.):. O-39.1f (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 泉薫,赤田隆,高橋成輔: "摘出内臓抵抗血管におけるノルエピネフリン収縮応答に及ぼすイソフルランの効果"J Anesth. 14(suppl.):. O-079.2 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 赤田隆,泉薫,中島幹夫: "内臓抵抗血管に対するケタミンの直接作用とその機序(抄録)"J Anesth. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 泉薫,赤田隆,高橋成輔: "内臓抵抗血管においてノルエピネフリン収縮反応に及ぼすハロタンの効果(抄録)"J Anesth. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 赤田隆: "吸入麻酔薬の血管への作用(教育講演抄録)"循環制御. 20(suppl.):. 23 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 赤田隆: "摘出内臓抵抗血管における揮発性吸入麻酔薬の作用(シンポジウム抄録)"J Anesth. 13(suppl.):. 45 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T, Boyle Ill WA: "Is guanosine-5'-triphophate involved in calcium-activation of contractile proteins in vascular smooth muscle?"Jpn J Pharmacol. 75. 1-12 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K, Akata T, Takahashi S: "The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteries Part I : role of endothelium."Anesthesiology. 92. 1426-1440 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T, Izumi K, Nakashima M: "The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteries. Part II : mechanisms of endothelium-independent vasorelaxation."Anesthesiology. 92. 1441-1453 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T, Nakashima M, Izumi K: "Comparison of volatile anesthetic actions on intracellular calcium stores of vascular smooth muscle-Investigation in isolated systemic resistance arteries-"Anesthesiology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T, Izumi K, Nakashima M: "Mechanisms of direct inhibitory action of ketamine on vascular smooth muscle in mesenteric resistance arteries."Anesthesiology (provisionally accepted January 3). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K, Akata T, Takahashi S: "Role of endothelium in the action of isoflurane on vascular smooth muscle of isolated mesenteric resistance arteries."Anesthesiology (provisionally accepted February 8). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T, Izumi K: "Volatile anesthetic actions on vascular smooth muscle (review)"Junkan-Seigyo (Circulation Control). 21(1). 61-83 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T, Izumi K, Kanna T, Yamakawa M, Takahashi S: "Differential effects of volatile anesthetics on intracellular calcium stores of vascular smooth muscle."Anesthesiology. 87(3A). A514 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T, Boyle Ill WA: "Is activation of G-proteins involved in calcium-activation of contractile proteins in vascular smooth muscle?"Anesthesiology. 87(3A). A603 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K, Akata T, Takahashi S: "Mechanisms of sevoflurane-induced reduction of the cytosolic free calcium concentration in vascular smooth muscle."Anesthesiology. 89(3A). A600 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K, Akata T, Takahashi S: "Endothelium-dependent vasoconstricting action of sevoflurane in the rat mesenteric resistance artery."Anesthesiology. 89(3A). A677 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T, Izumi K: "Effects of sevoflurane on calcium sensitivity of the contractile apparatus in vascular smooth muscle."Anesthesiology. 91(3A). A632 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K, Akata T, Takahashi S: "Persistent vascular hyporesponsiveness to norepinephrine after washout of sevoflurane in isolated rat mesenteric resistance arteries."Anesthesiology. 91(3A). A649 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K, Akata T, Takahashi S: "Which endothelium-derived vasoactive mediator is involved in the endothelium-dependent vasoconstricting action of sevoflurane?"Anesthesiology. 91(3A). A645 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kanna T, Akata T, Nakashima M et al.: "Sevoflurane Stimulates transmembrane calcium influx in pulmonary arterial valvular endothelial cells in situ."Anesthesiology. 91(3A). A658 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K, Akata T, Takahashi S: "The action of isoflurane on vascular smooth muscle of isolated mesenteric arteries."Anesthesiology. 93(3A). A604 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T, Nakashima M, Izumi K: "Effects of four inhaled anesthetics on intracellular calcium stores of vascular smooth muscle in small mesenteric arteries."Anesthesiology. 93 (3A). A594 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T, Izumi K, Nakashima M: "Effects of ketamine on vascular smooth muscle of rat mesenteric arteries."Anesthesiology. 93 (3A). A595 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akata T, Izumi K, Setoguchi H, Nagata T, Takahashi S: "Mechanisms of inhibitory actions of inhalational anesthetics on high K^+- induced contraction in splanchnic resistance arteries."Jpn J Pharmacol. 73 (suppl.-I). 202 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi K,Akata T,Takahashi S: "The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteries. Part I : role of endothelium."Anesthesiology. 92(5). 1426-1440 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Akata T,Izumi K,Nakashima M: "The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteries. Part II : mechanisms of endothelium-independent vasorelaxation."Anesthesiology. 92(5). 1441-1453 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Akata T,Nakashima M,Izumi K: "Comparison of volatile anesthetic actions on intracellular calcium stores of vascular smooth muscle-Investigntion in isolated systemic resistance arteries."Anesthesiology. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Akata T,Izumi K,Nakashima M: "Mechanisms of direct inhibitory action of ketamine on vascular smooth muscle in mesenteric resistance arteries."Anestheriology. (accepted January 3,2001)(in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Izumi K,Akata T,Takahashi S: "Role of endothelium in the action of isoflurane on vascular smooth muscle of isolated mesenteric resistance arteries."Anestheriology. (accepted February 8,2001)(in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] 赤田隆,泉薫: "吸入麻酔薬の血管への作用 -特にハロゲン化炭化水素型揮発性吸入麻酔薬が血管平滑筋あるいは血管内皮に及ぼす直接作用に注目して-"循環制御. 21(1). 61-83 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Izumi K,Akata T,Takahashi S: "The action of isoflurane on vascular smooth muscle of isolated mesenteric arteries."Anesthesiology. 93(3A). A604 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Akata T,Nakashima M,Izumi K: "Effects of four inhaled anesthetics on intracellular calcium stores of vascular smooth muscle in small mesenteric arteries."Anesthesiology. 93(3A). A594 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Akata T,Izumi K,Nakashima M: "Effects of ketamine on vascular smooth muscle of rat mesenteric arteries."Anesthesiology. 93(3A). A595 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 赤田隆,泉薫,中島幹夫: "内臓抵抗血管に対するケタミンの直接作用とその機序(抄録)"Journal of Anesthesia. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 泉薫,赤田隆,高橋成輔: "内臓抵抗血管においてノルエピネフリン収縮反応に及ぼすハロタンの効果(抄録)"Journal of Anesthesia. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Isumi K, Akata T, Takahashi S: "The action of sevoflurane on vascular ssmooth muscle of isolated mesenteric resistanc arteries. Part I: Role of endothelium."Anesthesiology. in press;accepted January 14, 2000.

    • Related Report
      1999 Annual Research Report
  • [Publications] Akata T, Izumi K, Nakashima M: "The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteriess.Part II Mechanisms of endothelium-independent vasorelaxation"Anesthesiology. in press;accepted January 14, 2000.

    • Related Report
      1999 Annual Research Report
  • [Publications] Akata T, Izumi K: "Effects of sevofurane on calcium sensitivity of the contractile appratus in vascular smooth muscle."Anesthesiology. 91(3A). A632 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Izumi K, Akata T, Takahashi S: "Persistent vascular hyporesponsiveness to norepinephrine after washout of sevofurane in isolated rat mesenteric resistance arteries."Anesthesiology. 91(3A). A649 (1999)

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      1999 Annual Research Report
  • [Publications] Izumi K, Akata T, Takahashi S: "Which endothelial-derived vasoactive mediator is involved in the endothelium-dependent vasoconstricting action of sevoflurane?"Anesthesiology. 91(3A). A645 (1999)

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      1999 Annual Research Report
  • [Publications] Kanna T, Akata T, Nakashima M et al.: "Sevoflurane stimulates transmembrane calcium influx in pulmonary arterial valvular endothelial cells in situ."Anesthesiology. 91(3A). A658 (1999)

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      1999 Annual Research Report
  • [Publications] 赤田 隆、泉 薫: "吸入麻酔薬の血管への作用"循環制御医学会雑誌. 21(1)(印刷中). (2000)

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      1999 Annual Research Report
  • [Publications] 赤田 隆: "揮発性吸入麻酔薬が内臓抵抗血管に及ぼす直接作用とその機序に関する研究"臨床研究奨励基金 1999年報. 2-10 (2000)

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      1999 Annual Research Report
  • [Publications] 赤田 隆、中島幹夫、泉 薫: "内臓抵抗血管において、各種揮発性吸入麻酔薬が血管平滑筋細胞内カルシウム貯蔵部位に及ぼす作用"Journal of Anesthesia. in press. (2000)

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      1999 Annual Research Report
  • [Publications] 泉 薫、赤田 隆、高橋成輔: "摘出内臓抵抗血管におけるノルエピネフリン収縮応答に及ぼすイソフルランの効果"Journal of Anesthesia. (in press). (2000)

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      1999 Annual Research Report
  • [Publications] 泉 薫、赤田 隆、高橋成輔: "摘出内臓抵抗血管平滑筋たいするセボフルランの効果" Journal of Anesthesia. 12(S). 1-D02-1- (1998)

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      1998 Annual Research Report
  • [Publications] 赤田 隆、泉 薫、高橋 成輔: "血管平滑筋細胞胞内Ca^<2+>貯蔵部位に対する4つの揮発性吸入麻酔の効" Journal of Anesthesia. 12. 3-P07-6- (1998)

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  • [Publications] K.izumi,T.Akata,S.Ttakahasi: "Mechanisms of sevoflurane-induced reduction of the cytosolic hree calc ium" Anesthesiology. 89. A-600- (1998)

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      1998 Annual Research Report
  • [Publications] K.izumi,T.Akata,S.Ttakahasi: "Endothelium-dependent vasoconstnicting action of sevofiurane in the rat mesentenic....." Anesthesiology. 89. A-677- (1998)

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      1998 Annual Research Report
  • [Publications] T.akata,T.kanna etai: "Cconparison of fingertip skin-surface temperature,central-fingertip temper ature........." Anesthesiology. 89. A-920- (1998)

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      1998 Annual Research Report
  • [Publications] 赤田 隆: "抹消循環評価における前腕指先皮膚表面温度較差測定の有用性に関する検討...." 日本臨床麻酔学会誌. 18(8). P470- (1998)

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  • [Publications] Takashi Akata et al.: "Is guanosine-5′-triphosphate involved in calciumactivation of contractile proteins in……?" Jpn.J.Pharmacology. 75(1). 1-12 (1997)

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      1997 Annual Research Report
  • [Publications] T.Akata et al.: "Differential effects of volatile anesthetics on intr intracellular calcium stores of vascular……" Anesthesiology. 87(3). A514- (1997)

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      1997 Annual Research Report
  • [Publications] T.Akata et al.: "Is activation of G-proteins involved in calciumactivation of contractile proteins in ……?" Anesthesiology. 87(3). A603- (1997)

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      1997 Annual Research Report
  • [Publications] T.Akata et al.: "Mechanisms of inhibitory actions of inhalational anesthetics on high K-induced contraction……" Jpn.J.Pharmacology. 73(SI). 202- (1997)

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      1997 Annual Research Report
  • [Publications] 赤田 隆、泉 薫、高橋 成輔: "摘出内臓抵抗血管における揮発性吸入麻酔薬のKCl収縮抑制作用のメカニズム" Journal of Anesthesia. 11(S). 313- (1997)

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      1997 Annual Research Report
  • [Publications] 泉 薫、赤田 隆、高橋 成輔: "内臓抵抗血管平滑筋に対する揮発性吸入麻酔薬の効果" Journal of Anesthesia. 11(S). 310- (1997)

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      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2017-10-11  

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