| Project/Area Number |
09470361
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
NAKANO Hitoo Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Professor, 大学院・医学系研究科, 教授 (40038766)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKIMORI Kiyomi Maternity and Perinatal Care Unit, Kyushu University Hospital, Assistant Professor, 医学部, 講師 (90253450)
SATO Shoji Maternity and Perinatal Care Unit, Kyushu University Hospital, Assistant Professor, 医学部, 講師 (00225947)
KOYANAGI Takashi Department of Human Development, Graduate School of Medical Sciences, Kyushu University, Professor, 大学院・医学系研究科, 教授 (30136452)
HORIMOTO Naoki Department of Human Development, Graduate School of Medical Sciences, Kyushu University, Research Associate, 大学院・医学系研究科, 助手 (40243927)
高島 健 九州大学, 医学部, 助手 (30294953)
吉里 俊幸 九州大学, 医学部, 助手 (80264034)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 1999: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1998: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1997: ¥7,500,000 (Direct Cost: ¥7,500,000)
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| Keywords | human fetus / biological clock / eye movement / ultradian rhythm / circadian rhythm / ontogeny / REM / NREM sleep / ウルトラディアンリズム / レム睡眠 / ノンレム睡眠 / スペクトル解析 / 超音波電子スキャン / 時間生物学 / 胎児行動 / 位相同調 / 心拍数変動 |
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| Research Abstract |
The aim of this research project is to elucidate the developmental process of ultradian and circadian rhythms in the human fetus in utero, from the view point of the ontogeny of the biological clock.
It was evident that : (1) The controlling center of ultradian rhythm (seen in eye movement / no eye movement period alternation or FHR variation), lying in the ponto-medullar region, starts to function at around 30 weeks' gestation and reaches maturation at term. (2) With regard to the sleep and waking states in the human fetus, both slow eye movement coexisting with rapid eye movement at 33 weeks' gestation onwards, and penile tumescence relating to the eye movement period as well, suggest that the generating center of REM sleep in the pons is functioning. (3) At 35 weeks' gestation onwards, regular mouthing movement concurrent with the no eye movement period indicates that this period is comparable to NREM sleep, thereby suggesting that the neural center, responsible for NREM sleep, from the pons through the thalamocortical pathway to the cerebral hemisphere may begin to function at around 35 weeks' gestation. (4) The temporal relationship between the onset of the eye movement period and micturition at term may be interpreted by the anatomical proximity of the controlling parts of both phenomena in the pons, and their interaction during the course of development. (5) Two different conditions emerge from fetal stomach movement, at the latest at 27 weeks' gestation, and begin manifesting from 29 weeks' onwards. The chronological changes in these conditions cluster into 'active' and 'quiet' phases from 31 weeks' gestation onwards. (6) Using maximum entropy power spectral analysis, the eye movement pattern at term was revealed to have a 16-29 hour periodicity.
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