| Project/Area Number |
09470363
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B).
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
KUDO R School of Medicine, Sapporo Medical University Professor, 医学部, 教授 (70045409)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAITO Tsuyoshi School of Medicine, Sapporo Medical University Assistant Prof., 医学部, 講師 (90145566)
SAGAE Satoru School of Medicine, Sapporo Medical University Associate Prof., 医学部, 助教授 (00187056)
ITO E School of Medicine, Sapporo Medical University Associate Prof., 医学部, 助教授 (60136918)
NISHIKAWA Akira School of Medicine, Sapporo Medical University Assistant Prof., 医学部, 助手 (70295351)
KOIZUMI Motoiki School of Medicine, Sapporo Medical University Assistant Prof., 医学部, 講師 (50244348)
|
|---|
| Project Period (FY) |
1997 – 2000
|
| Project Status |
Completed (Fiscal Year 2000)
|
| Budget Amount *help |
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
|---|
| Keywords | gynecologic cancers / histological types / invasive potential / motility / metastasis potential / MMP |
|---|
| Research Abstract |
We have performed research factors which are considered to affect invasive potential and metastasis on histological types in the gynecologic cancers.
The research results are summarized as follows.
1). The endometrial cancer cells which were transfected with estrogen receptor, showed increased proliferation and promoted invasive potential after giving estrogen.
2). Expression intensity of E-cadherin and catenin showed reverse correlation to invasive and metastasis potential.
3). We have researched on the correlation of invasive potential and motility in the endometrial cancer cells. Higher expression of integrin β1 on the cellular membrane was seen in the higher motile cell lines.
4). We have studied immunohistochemical expression of CD9 which are considered as a motility molecule in the cancer cells. Cervical cancer cases with CD9 positive had significantly higher positive lymph nodes than those with CD9 negative.
5). The expression of MMP-2, MT1-MMP and the activation of MMP-2 in the ovarian cancer cells are important factors for invasive potential.
|
