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Electrophysiological analysis of the lateral reticular formation controlling orofacial autonomic and motor functions

Research Project

Project/Area Number 09470402
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionOkayama University (1998)
Osaka University (1997)

Principal Investigator

MATSUO Ryuji  Okayama University, Dentistry, Professor, 歯学部, 教授 (30157268)

Co-Investigator(Kenkyū-buntansha) MASUDA Yuji  Osaka University, Dentistry, Assistant, 歯学部, 助手 (20190366)
INOUE Tomio  Osaka University, Dentistry, Lecturer, 歯学部, 講師 (70184760)
MITHO Yoshihiro  Okayama University, Dentistry, Assistant, 歯学部, 助手 (20240872)
FUNAHASHI Makoto  Okayama University, Dentistry, Assistant, 歯学部, 助手 (80221555)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 1998: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1997: ¥8,600,000 (Direct Cost: ¥8,600,000)
Keywordsreticular formation / superior salivatory nucleus / salivary secretion / iaw movement / tongue movement / taste / patch clamp / rat / 血流
Research Abstract

Neural network in the brainstem subserving autonomic and motor oral functions was investigated by anatomical, electrophysiological and behavioral studies. In the anatomical study, FTTC and Rhodamine were injected into the anterior part of the tongue or the secretory nerve of the subamndibular gland, respectively, and the superior salivatory (SS) neurons innervating the tongue and those innervating the submandibular salivary glands were identified in rats. The two groups of SS neurons were similar in shape and intermingled in the lateral reticular formation. In the electrophysiological study, biophysical properties of the SS neurons were analyzed by the whole-cell patch clamp technique in sliced brainstem preparations. The SS neurons innervating the tongue displayed a prominent transient outward current (A-current), and fired up to 70 Hz. Those innervating the salivary glands expressed A current lasting longer period, and fired up to 30 Hz. Post-natal development of the A-currents was observed when we compared between A- currents of one-week and two-week old rats. In behavioral study, salivary flow from the submandibular gland and activity of the masseter muscle were chronically recorded from the freely moving rats, During chewing, the amount of saliva and muscle activity were not always parallel, suggesting different centrifugal effects on autonomic and motor functions.
Through these studies, we conclude that the autonomic and motor oral functions are under control from the higher central nervous system, but there is a contact point between the two functions in the lower brainstem especially the lateral reticular formation. A further study is needed to clarify relationship between feeding behavior and blood flow rate of the tongue.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 小林, 真之: "Role of calcium conductances on spike after potentials in rat trigeminal motoneurons." Journal of Neurophysiology. 77. 3273-3283 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 松尾, 龍二: "Role of lateral hypothalamus and oral sensation on salivation during chewing in rats." Neuroscience Research. 21, 補冊. S285 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 山内, 洋二: "Role of the parabrachial subnucleus in salivation induced by rejectable taste in rats." Neuroscience Research. 21, 補冊. S232 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 松尾, 龍二: "Neural activity of the superior salivatory nucleus in rats." European Journal of Morphology. 36. 203-207 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 松尾, 龍二: "Two types of parasympathetic preganglionic neurones in superior salivatory nucleus characterized electro physiologically in slice preparations" Journal of Physiology. 5/3. 157-170 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 松尾, 龍二: "Effect of lateral and ventromedial hypothalamic activity on salivation in rats during chewing" Japanes Journal of physiology. 48補冊. S175 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kobayashi, Masayuki: "Role of calcium conductances on spike afterpotentials in rat trigeminal motoneurons." Journal of Neurophysiology. 77. 3273-3283 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuo, Ryuji: "Role of lateral hypothalamus and oral sensation on salivation during chewing in rats." Neuroscience Research. 21 Suppl. S285 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamauchi, Yoji: "Role of the parabrachial subnucleus in salivation induced by rejectable taste in rats." Neuroscience Research. 21 Suppl. S232 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuo, R.yuji: "Neural activity of the superior salivatory nucleus in rats. in rats." European Journal of Morphology. 36. 203-207 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuo, R.yuji: "Two types of parasympathetic preganglionic neurones in superior salivatory nucleus characterized electrophysiologically in slice preparations of neonatal rats." Journal of Physiology. 513. 157-170 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuo, R.yuji: "Effect of lateral and ventromedial hypothalamic activity on salivation in rats during chewing." Japanese Journal of Physiology. 48 Suppl. S175 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary

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Published: 1997-04-01   Modified: 2016-04-21  

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