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Pulpal inflammation alters the physiological properties of intradental nerves in the adjacent teeth

Research Project

Project/Area Number 09470421
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KAWASHIMA Nobuyuki (1998-1999)  Tokyo Med. & Dent. Univ. Research Associates, 歯学部, 助手 (60272605)

山本 寛 (1997)  東京医科歯科大学, 歯学部, 助手 (30242209)

Co-Investigator(Kenkyū-buntansha) SUNAKAWA Mitsuhiro  Tokyo Med. & Dent. Univ. Lecturer, 歯学部, 講師 (30179288)
SUDA Hideaki  Tokyo Med. & Dent. Univ. Professor, 歯学部, 教授 (00114760)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1997: ¥5,300,000 (Direct Cost: ¥5,300,000)
KeywordsDental Pulp / Pulpal Blood Flow / Pulpal Nerve / Branched Nerve Fiber / Mustard Oil / Axon Reflex / Cat / Laser Doppler Flowmeter / 歯髄神経 / 分岐歯髄神経 / 神経原性炎症
Research Abstract

Stimulation of the tooth crown induces vasodilation in the tooth pulp. This vasodilation seems to be mediated by the release of neuropeptides from the terminals of activated fine caliber afferent fibers. It has been suggested that the vasodilator response in the pulp spread as an axon reflex along the peripheral nerve branches when the tooth pulp is stimulated. On the other hand, branched dental nerves supplying the pulps of multiple teeth have been identified by electrophysiological and anatomical studies.
The aims of this study were to investigate whether pulpal blood flow changes and intradental nerve activity can be induced by stimulation of an adjacent tooth to confirm the existence of branched afferents innervating both tooth pulps.
Mustard oil or mechanical stimulation was applied to maxillary second premolar tooth pulps and pulpal blood flow and/or intradental nerve activity in the ipsilateral canine tooth were recorded in the cat. Mustard oil application to the second premolar p … More ulp significantly increased blood flow in the canine tooth. Sectioning of the infraorbital nerve and its branches on the experimental side did not affect this pulpal blood flow increase. The paraperiosteal injection of lidocaine without vasoconstrictor significantly inhibited the canine pulpal blood flow increase induced by mustard oil application to the second premolar pulp. Sporadic firing or sometimes bursts of action potentials in the canine pulp nerves were recorded during and/or after the mustard oil application to the second premolar pulp in some cases. Single pulp nerve units firing in synchrony with the mechanical stimulation of the second premolar pulp were recorded in some canines, which substantiated the existence of branched afferents innervating both teeth. These findings suggest that stimulation of the second premolar pulp may induce axon reflex-related vasodilation and intradental nerve firing in the canine pulp via branched afferent fibres innervating both the second premolar and canine teeth. Less

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] M.Sunakawa et al.: "Jaw electromyographic activity induced by the application of algesic chemicals to the rat tooth pulp"Pain. 80(3). 493-501 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N.Kawashima et al.: "Infection-stimulated infrasseus inflammation and bone destruction is increased in P-/E-selectin knockout mice"Immunology. 97(1). 117-123 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N.Kawashima et al.: "Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation"Archives of Oral Biology. 44(1). 55-66 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 引地朱美ら: "ネコ犬歯歯髄血流と歯髄内神経活動に対する前臼歯歯髄刺激の影響"口腔病学会誌. 66. 415 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.Hikiji et al.: "Increased blood flow and nerve firing in the cat canine tooth in response to stimulation of the second premolar pulp"Archives of Oral Biology. 45(1). 53-61 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 山本寛ら: "痛みの臨床各論 歯と歯根膜の痛み"医歯薬出版. 305 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Sunakawa et al.: "Neurobiology of Mastication-from Molecular to Systems Approach."Elsevier Science. 525 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Sunakawa et al.: "Jaw electromyographic activity induced by the application of algesic chemicals to the rat tooth pulp."Pain. 80(3). 493-501 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N. Kawashima et al.: "Infection-stimulated infraosseus inflammation and bone destruction is increased in P-/E-selectin knockout mice."Immunology. 97(1). 117-123 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N. Kawashima et al.: "Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation."Archives of Oral Biology. 44(1). 55-66 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A. Hikiji et al.: "Increased blood flow and nerve firing in the cat canine tooth in response to stimulation of the second premolar pulp."Archives of Oral Biology. 45(1). 53-61 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Sunakawa et al.: "Neurobiology of Mastication-from Molecular to Systems Approach."Elsevier Science. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Sunakawa et al.: "Jaw electromyographic activity induced by the application of algesic chemicals to the rat tooth pulp."Pain. 80(3). 493-501 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] N. Kawashima et al.: "Infection-stimulated infraossus inflammation and bone destruction is increased in P-/E-selectin knockout mice."Immunology. 97(1). 117-123 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] N. Kawashima et al.: "Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation."Archives of Oral Biology. 44(1). 55-66 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 引地 明美ら: "ネコ犬歯歯髄血流と歯髄内神経活動に対する前臼歯歯髄刺激の影響"口腔病学会誌. 66. 415 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] A. Hikiji et al.: "Increased blood flow and nerve firing in the cat canine tooth in response to stimulation of the second premolar pulp."Archives of Oral Biology. 45(1). 53-61 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 山本 寛ら: "痛みの臨床各論 歯と歯根膜の痛み"医歯薬出版. 305 (1997)

    • Related Report
      1999 Annual Research Report
  • [Publications] M. Sunakawa et al.: "Neurobiology of Mastication-from Molecular to Systems Approach."Elsevier Science. 525 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Yamamoto et al: "Stimulation Applied to a Tooth Affects the Intradental Nerve Activity of Another Tooth" J Dent Res. 76・5. 1180- (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Yamamoto et al: "Srimulation Applied to a Tooth Affects the Intradental Nerve Activity of Another Tooth" J Dent Res. 76 Special Issue. 301- (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Narhi et al: "Response of Pulp Nerves to Mustard Oil and Capsaicin" J Dent Res. 76 Special Issue. 57- (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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