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Experimental Polyalkenoate Cements Based on the Bioactive Glass

Research Project

Project/Area Number 09470439
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MATSUYA Shigeki  Kyushu Univ., Faculty of Dentistry, Associate Professor, 歯学部, 助教授 (00108755)

Co-Investigator(Kenkyū-buntansha) OHTA Michio  Kyushu Univ., Faculty of Dentistry, Professor, 歯学部, 教授 (30037824)
MATSUYA Youko  Kyushu Univ., Faculty of Dentistry, Research Associate, 歯学部, 助手 (50128097)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 1998: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥10,200,000 (Direct Cost: ¥10,200,000)
Keywordsbioactive glass / glass ionomer cement / NMR / silicate glass / setting mechanism / IR / polyacrylic acid / 生体活性 / アパタイト
Research Abstract

We -prepared a new glass ionomer cement using the bioactive CaO-P_2O_5-SiO_2(-MgO) glasses and investigated its setting process using FT-IR and MAS NMR analyses and their bioactivity. Compressive strength of the cements depended on the glass composition and the maximum strength of 33.3 4.7 MPa was obtained with the cement using the glass composition of MgO : 4.6, CaO : 44.9, SiO_2 : 34.2 and P_2O_5 : 16.3% in weight. The FT-JR analysis shows that COON group in the polyacrylic acid decreased and carboxylate ion (COO-Ca^<2+>) increased after the setting reaction. A broad signal appeared around -82 ppm in ^<29>Si MAS-NMR spectra of the glasses and a new signal corresponding to hydrated silica gel formation appeared around -102 and -111 ppm after setting. This fact suggests that Ca^<2+> was released from the glass powder to form the carboxylate salt and that a degree of polymerization in silicate network increased, With the glass containing Al, Al ion existed as tetrahedral position in the original glass. As the setting reaction proceeded, however, it was released from the glass as hexa-coordinated Al^<3+> hydrate ion to form cross-linking with COO^- groups in the acid molecule. The setting mechanism of the cement was found to be essentially the same in the conventional glass ionomer cement. In vitro bioactivity of the set cement was inferior to that of the original glasses. This was probably because of capture of Ca^<2+> ion by the carboxyl group in the acid molecule. It is necessary to improve the mechanical strength and bioactivity to use the cement as an alternative of the hard tissue. For that purpose we should consider the composition of the glass, the sort of the polymer acid and its molecular weight.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] S.Matsuya et al.: "Structure of the Bioactive Glass and its Application to Glass Ionomer Cements" Dental Materials Journal. 17・2印刷中. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Matsuya et al.: "Effect of powder grinding on hydroxyapatite formation in polymeric calcium phosphate cement prepared from tetracalcium phosphate and poly(methyl yinyl ether-maleic acid)" Bioamaterials. 20・7. 691-697 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Matsuya, Y.Matsuya and M.Ohta: "Structure of the Bioactive Glass and its Application to Glass Ionomer Cements" Dental Materials Journal. 17-2 (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Matsuya, S.Matsuya, J.M.Antonucci, S.Takagi, L.C.Chow, A.Akamine: "Effect of powder grinding on hydroxyapatite formation in a polymeric calcuim phosphate cement prepared from tetracalcium phosphate and poly (methyl vinyl ether-maleic acid)" Bioamaterials. 20-7. 691-697 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary

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Published: 1997-04-01   Modified: 2016-04-21  

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