| Project/Area Number |
09470456
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
ISHIKAWA Takenori Hiroshima Univ., Dept.Oral Surg., Chief prof., 歯学部, 教授 (10049380)
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Tdashi Hiroshima Univ., Dept.Oral Surg., Lecturer, 歯学部・附属病院, 講師 (50238185)
SUGIYAMA Masaru Hiroshima Univ., Dept.Oral Surg., Assoc.Prof., 歯学部, 助教授 (70187681)
辻野 哲弘 広島大学, 歯学部, 助手 (00243585)
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| Project Period (FY) |
1997 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2000: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1999: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1997: ¥7,400,000 (Direct Cost: ¥7,400,000)
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| Keywords | p53 / p21 / p14 / CD44 / p16 / p53-pathway / Rb-pathway / cyclin / mdm2 / 口腔白板症 / 口腔扁平上皮癌 / P53-ARF経路 / 唾液線腫瘍 / 遺伝子 / 腺上皮 / 筋上皮 / mRNA / 蛋白 / 口腔癌 / 胃癌 / 細胞周期関連因子 / Cyclin F / Cyclin D / CDK2 / Cyclin E / Rb |
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| Research Abstract |
Malignant-changing process of oral leukoplakia might surely demand hypoexpression of p14ARF and further abnormal occurrence of p53-ARF pathway. In case of oral SCC, it was suggested that expression of mutant p53, hypoexpression of p14ARF, p16 loss, hyperexpression of Cyclin D, phospholization of Rb, complete deficit of FHIT etc will be strongly correlated to the occurrence, infiltration and development of oral SCC.Furthermore, osteopontin might produce a possibility of distant metastasis by combination with CD44. In salivary gland tumors, it was supposed that p53, p21, Cyclin E and D showed different tendency in proliferation mechanism of general epithelia and myoepithelia of salivary gland. Between SCC and adenocarcinoma, arising from salivary gland and stomach, there were clearly guessed differences in the related pathologic conditions. In case of B-cell Hodgikin's lymphoma (NHL), p53 expression surely showed correlation between chemotherapy and its effect, resulting in becoming possible marker for prognosis.
From above experimental results, both of two pathways of p53 and Rb may correlate occurrence and proliferation of oral cancers, based on different histologic types and connected conditions.
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