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Clinical study on changes and adaptations of physiological functions after orthognathic surgery

Research Project

Project/Area Number 09470467
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 矯正・小児・社会系歯学
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KATO Yoshiyuki  Tokyo Medical and Dental University, Second Department of Orthodontics, Assistant Professor, 歯学部, 助手 (30224554)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1998: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1997: ¥4,100,000 (Direct Cost: ¥4,100,000)
KeywordsTongue / Orthognathic surgery / Genioglossus muscle / Single motor unit / Respiration / Jaw deformity / Upper airway / Temporomandibular-joint disorder / 反射 / Cervical Headgear / 上部気道 / 睡眠呼吸障害
Research Abstract

A) The genioglossus (GG) muscle shows a phasic inspiratory activity superimposed on tonic activity to maintain upper airway (UA) patency. However, discharge properties of single GG motor unit (MU) with respiratory-related activity remain to be determined. Single unit activities of 24 GG MUs with respiratory-related discharge were recorded during spontaneous nasal breathing in both the natural head position and 30゚ head-up position in 8 adult males. The inspiratory MU (IMU) showed the phasic activity during inspiration, whereas the inspiratory-expiratory MU (IEMU) showed the phasic inspiratory activity superimposed on the tonic activity. The firing duration and instantaneous firing frequency (1FF) of the IMU during inspiration significantly increased in the 30゚ head-up position. Although the 1FF of the IEMU also significantly increased in the 30゚ head-up position, there was no significant difference between inspiratory and expiratory phases. An interspike interval analysis demonstrated … More that the functional divergence of the IMU and IEMU.
B) (1) To investigate morphologic changes in oropharyngeal structures in mandibular prognathic patients after or thognathic surgery, 25 patients with mandibular prognathism who had undergone surgical and or thognathic treatment were used. A set of 4 standardized lateral cephalograms were obtained from each subject preoperatively and at 3 months, 6 months, and I year postoperatively. Morphologic changes in UA structures were evaluated longitudinally by gender. Parameters of the anteroposterior width of the pharynx significantly decreased at 3 and 6 months in both genders, and these parameters tended to rebound to the preoperative values 1 year postoperatively in females, but not in males. The hyoid hone significantly descended inferiorly 1 year postoperatively in males, white there were no significant changes in females. The distance between the hyoid bone and the third vertebra gradually decreased in males postoperatively ; however, there were no significant changes in females. The cross-sectional area of the hypopharynx significantly decreased 1 year postoperatively in males, but not in females. These results indicate that the UA morphology changed differently in males and females following surgery. To compensate fro skeletal changes following surgery, it appears that males and females responded in differently ways to preserve a functional UA.(2) To extract characteristic three-dimensional dentofacial changes during retention and to clarify morphological factors affecting the stability of postoperative occlusion in mandibular prognathic patients with open bite and asymmetry, 7 adult patients were used. Changes in denture and skeletal components, and anterior occlusion during retention were analyzed three-dimensionally using the lateral and frontal cephalograms. Results indicated that it was important to maintain long-term stability of the anterior occlusion in the vertical dimension in patients with three-dimensional dentofacial deformity.
C) (1) To investigate the relationship between the etiologic factors such as gender, age, and general joint mobility and temporomandibular joint (TMJ) disorders, 110 orthodontic patients were used. Fifty of 78 females and 17 of 32 males showed symptoms of TMJ disorders. No significant gender difference was observed in the prevalence of TMJ disorders. However, TMJ and muscular pain and difficulty in mouth opening were more frequently observed in female symptomatic patients than male patients. There was a significant relative risk of TMJ disorders associated with increasing age. Higher score of general joint mobility was also significantly associated with an increased risk of TMJ disorders. (2) The frequency of TMJ disorders in 174 patients with jaw deformities was surveyed by questionnaires and dental casts. The frequency of reported present or past TMJ disorders was 77.6%. No difference by gender was observed. When the frequency of TMJ disorders in different age groups was examined, the youngest being 15 years of age followed by others at increasing age intervals of 5 years, there was no significant difference between age groups. Among 135 symptomatic patients, 49 patients (36.3%) reported only one symptom of TM) disorders, while 86 patients (63.7%) reported two or more symptoms. As for potential etiologic factors and historical events, poor posture and experience of trauma were more frequently observed among symptomatic patients than asymptomatic patients. There was no significant difference in the frequency of TMJ disorders between different occlusomorphologic types. Less

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] 加藤嘉之,本橋信義,他: "顎変形症患者における顎関節症の統計的観察" 日顎変形誌. 7. 40-48 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ono T,Ishiwata Y,et al.: "Swallowing-related perihypoglossal neurons projecting to hypoglossal motoneurons in the cat" J.Dent.Res.77. 351-360 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 加藤嘉之,五十嵐一吉,他: "顎関節症に関与する因子の検討" 日顎誌. 10. 71-80 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 川元龍夫,本橋信義,他: "開咬ならびに下顎非対称を伴う骨格性下顎前突症7症例の術後の顎態変化" 日顎変形誌. 8. 203-212 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ono T,Ishiwata Y,et al.: "Inhibition of masseteric electromyographic activity during oral respiration" Am.J.Orthod.Dentofac.Orthop.113. 518-525 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ono T,Ishiwata Y,et al.: "Modulation of the inspiratory-related activity of hypoglossal premotor neurons during ingestion and rejection in the decerebrate cat" J.Neurophysiol.80. 48-58 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kato Y et al.: "Clinical statistical study on TMJ disorders in patients with jaw deformities" Jpn.J.Jaw Deform. 7. 40-48 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ono T et al.: "Swallowing-related perihypoglossal neurons projecting to hypoglossal motoneurons in the cat" J.Dent.Res.77. 351-360 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kato Y et al.: "Epidemiologic factors for TMJ disorders-gender, age, and general joint mobility-" J.Jpn.Soc.TMJ. 10. 71-80 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kawamoto T et al.: "Dentofacial changes following orthognathic surgery in seven mandibular prognathic patients with open bite and mandibular asymmetry" Jpn.J.Jaw Deform.8. 203-212 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ono T et al.: "Inhibition of masseteric electromyographic activity during oral respiration" Am.J.Orthod. Dentofac. Orthop.113. 518-525 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ono T et al.: "Modulation of the inspiratory-related activity of hypoglossal premotor neurons during ingestion and rejection in the decerebrate cat" J.Neurophysiol.80. 48-58 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakagawa F et al.: "Morphologic changes in the upper airway structure following surgical correction of mandibular prognathism" Int.Adult Orthod. Orthognath. Surg. 13. 299-306 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ono T,Ishiwata Y,et al.: "Swallowing-related perihypoglossal neurons projecting to hypoglossal motoneurons in the cat" J.Dent.Res.77. 351-360 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 檜山成寿,小野卓史,他: "Cervical headgear装着に伴う口腔咽頭領域の形態変化" Orthod.Waves. 57. 77-82 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ono T,Ishiwata Y,et al.: "Inhibition of masseteric electromyographic activity during oral respiration" Am.J.Orthod.Dentofac.Orthop.113. 518-525 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ono T,Ishiwata Y,et al.: "Modulation of the inspiratory-related activity of hypoglossal premotor neurons during ingestion and rejection in the decerebrate cat" J.Neurophysiol.80. 48-58 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 川元龍夫,本橋信義,他: "開咬ならびに下顎非対称を伴う骨格性下顎前突症7症例の術後の顎態変化" 日顎変形誌. 8. 203-212 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakagawa F,Ono T,et al.: "Morphologic changes in the upper airway structure following surgical correction of mandibular prognathism" Int.J.Adult Orthod.Orthognath.Surg.13. 299-306 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 檜山成寿, 小野卓史, 他: "Headgear装着に伴う咀嚼筋,オトガイ舌筋および胸鎖乳突筋筋活動の変化様相" 日矯歯誌. 56. 75-82 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 加藤嘉之, 本橋信義, 他: "顎変形症患者における顎関節症の統計的観察" 日顎変形誌. 7. 40-48 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 檜山成寿, 小野卓史, 他: "Headgear装着に伴う頭位の変化" 日矯歯誌. 56. 281-288 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小野卓史, 横関雅彦, 他: "口蓋扁桃切除術を行った骨格性下顎前突症例-上部気道の形態・位置変化に着目して-" 東矯歯誌. 7. 44-48 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ishiwata Y, Hiyama S, et al.: "Human jaw-tongue reflex as revealed by intraoral surface recording" J.Oral Rehab.24. 857-862 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tsuiki S, Ono T, et al.: "Modulation of respiratory-related genioglossus motor unit activity associated with changes in head position in humans" Jpn.J.Oral Biol.40. 53-61 (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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