| Project/Area Number |
09470471
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
TANNE Kazuo Hiroshima University School of dentistry, Professor, 歯学部, 教授 (30159032)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Hiroshi Hiroshima University Dental Hospital, Research Associate, 歯学部・附属病院, 助手 (20304446)
SUGIYAMA Hiroki Hiroshima University School of Dentistry, Research Associate, 歯学部, 助手 (10294571)
TANAKA Eiji Hiroshima University Dental Hospital, Assistant Professor, 歯学部・附属病院, 講師 (40273693)
MIYAMOTO Keisuke Hiroshima University Dental Hospital, Assistant Professor, 歯学部・附属病院, 講師 (40229886)
河田 俊嗣 広島大学, 歯学部, 助手 (80281161)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 1998: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1997: ¥7,600,000 (Direct Cost: ¥7,600,000)
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| Keywords | Mastication / Occlusion / Mechanical stimuli / Sensory input / Central nervous system / Osteopetrotic mice / Masticatory muscle activity / 顎顔面形態 / 縫合成長 / 破骨細胞 / 大理石骨病マウス / 骨粗鬆症 |
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| Research Abstract |
In recent years, an important role of the tooth and the relevant functions such as biting, chewing and mastication has been addressed. Under such background, the present study was designed to investigate the influences of stomatognathic functions on the development of the other tissues and organs, the central nervous system in particular, by use of rats and mice as experimental animals and human subjects.
In an experiment with osteopetrotic (op/op) mice involved with defects in osteoclastic activity and tooth eruption, the reduced masticatory function produced a decrease in the number of neurons in the central nervous system. Such phenomena were similarly observed in normal mice and rats subjected to artificial reduction in mechanical stimuli from mastication and physical exercise. These findings were eliminated to some extent, approaching the normal controls, by an artificial injection of osteoclast induction agents, which generate tooth eruption and recover in masticatory function. Furthermore, . mechanical stimuli to the teeth in rats induced a specific C-fos protein in the central nervous system. Meanwhile, such association in humans has been studied by use of a portable electromyogram recorder, demonstrating the nature of masticatory function in subjects with occiusal discrepancy. In conclusion, it is emphasized that external mechanical stimuli from stomatognathic functions substantially affect the development of the central nervous system, indicating an important role of the dentition and the related masticatory function.
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