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Molecular mechanisms of glial activation and cell death

Research Project

Project/Area Number 09470504
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionOsaka University

Principal Investigator

BABA Akemichi  Graduate school of pharmaceutical sciences, Osaka University Professor, 薬学研究科, 教授 (70107100)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Hitoshi  Graduate school of pharmaceutical sciences, Osaka University Assistant Professor, 薬学研究科, 講師 (30240849)
MATSUDA Toshio  Graduate school of pharmaceutical sciences, Osaka University Professor, 薬学研究科, 教授 (00107103)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1998: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1997: ¥9,900,000 (Direct Cost: ¥9,900,000)
Keywordsastroglia / neuron / cell death / endothelin / ischemia / NaィイD1+ィエD1-CaィイD12+ィエD1 antiporter / calcineurin / gliosis
Research Abstract

This study was aimed to clarify the functional roles of glial cells in neuron-glia interactions in pathological situations, such as ischemic brain injury. The following results were obtained.
1. A stab wound injury on rat cerebral cortex increased immunoreactive endothelin-1 and reactive astrocytes at the injured site, and this was reversed by a endothelin B receptor antagonist.
2. Endothelin induced cytoskeletal actin re-organization in cultured astrocytes, and this action was dependent on activation of the small GTP-binding protein Rho, and tyrosine phosphorylation of focal adhesion proteins.
3. CaィイD12+ィエD1depletion followed by reperfusion with CaィイD12+ィエD1-containing medium causes cell death in cultured astrocytes (CaィイD12+ィエD1paradox-like injury), but not in neurons. This was triggered by an increased CaィイD12+ィエD1 influx through NCX in the reverse mode followed by generation of reactive oxygen species and activation of calcineurin and NF-κB.
4. The CaィイD12+ィエD1 paradox-like injury was attenuated by inhibitors of NCX, calcineurin, caspase, or cathepsine, and also by cognitive enhancers, and nerve growth factor (NGF).
In the present study, we revealed that endothelin signalling are involved in morphological astrocytic changes and cellular actions (activation). We also investigated the mechanisms underlying delayed glial cell death with respect to NCX activation and intracellular signaling molecules, and revealed that the CaィイD12+ィエD1paradox injury of cultured astrocytes is considered to be an in vitro model of ischemia/reperfusion injury. It is anticipated that these studies on activation and cell injury of astrocytes will contribute to development of new drugs that modulate the function of astrocytes.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (81 results)

All Other

All Publications (81 results)

  • [Publications] Yutaka Koyama: "Induction of glutamine synthetase by L-a-aminoadipate in developmental stages of cultured astrocytes"Neurosci. Lett.. 233. 65-68 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nobue Ishikawa: "Endothelins promote the activation of astrocytes in rat neostriatum through ET_B Receptors"Eur. J. Neurosci.. 9. 895-901 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Rie Hosoi: "Isoform-specific up-regulation by ouabain of Na^+, K^+-APTase in cultured rat astrocytes"J. Neurochem.. 69(5). 2189-2196 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshio Matsuda: "Na^+-Ca^<2+> exchanger : physiology and pharmacology"Jpn. J. Phamacol.. 74(1). 1-20 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shioichi Asano: "Interaction of orally administered 5-{3-[((sS)-1, 4-benzodioxan-2-ylmethyl)amino]propoxy}-1, 3-benzodioxal(MKC-242) with 5-HT_<1A> receptors in rat brain"Jpn. J. Phamacol.. 74(1). 69-75 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shioichi Asano: "Inhibition by nitric oxide of the uptake of [^3H] serotonin into rat brain synaptosomes"Jpn. J. Phamacol.. 75(2). 123-128 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Pranee Somboonthum: "MKC-242, a novel 5-HT_<1A> receptor agonist, facilitates cortical acetylcholine release by a mechanism different from that of 8-OH-PAT in awake rats"Neuropharmacology. 36(11-12). 1733-1739 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroyuki Nogi: "Destribution of mRNAs for pituitary adenylate cyclase-activeting polypeptide (PACAP), PACAP receptor, vasoactive intestinal polypeptide(VIP), and VIP receptors in the rat superior cervical ganglion"Neurosci. Lett.. 227(1). 37-40 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hitoshi Hashimoto: "Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide receptor chimeras reveal domains that determine specificity of vasoactive intestinal polypeptide binding and activation"Mol. Pharmacol.. 52(1). 128-135 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroyuki Nogi: "Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor mRNA in the rat adrenal gland : localization by in situ hybridization and identification of splice variants"Mol. Pharmacol.. 75(2). 203-207 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松田敏夫: "アストロサイトの活性化とグリア細胞死"日薬理誌. 109. 153-159 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 遠山正彌: "アストロサイトのシグナル伝達と機能"日薬理誌. 110. 129-131 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 橋本均: "Pituitary adenylate cyclase-activating polypeptide(PACAP)受容体の構造および機能"ビタミン. 71. 285-296 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kyoto Takahashi: "Effect of taurine on angiotensin II-induced hypertrophy of neonatal rat cardiac cells"J. Cardiovas. Pharmacol.. 30. 725-730 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akemichi Baba: "Role of endothelin B receptor signals in reactive astrocytes"Life Sci.. 62. 1711-1715 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshio Matsuda: "Involvement of calcineurin in Ca^<2+> paradox-like injury of cultured rat astrocytes"J. Neurochem.. 70(5). 2004-2011 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kyohei Yamamoto: "Cloning and Characterization of the mouse pituitary adenylate cyclase-activating polypeptide (PACAP) gene"Gene. 211(1). 63-69 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松田敏夫: "脳虚血へのNa^+-Ca^<2+>アンチポーター応答とグリア/ニューロン死"日薬理誌. 111(1). 13-19 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松田敏夫: "Na^+-Ca^<2+>交換系とアストログリア細胞死"脳機能の解明-21世紀に向けて-. 499-507 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松田敏夫: "グリア/ニューロン死におけるNa^+-Ca^<2+>アンチポーターの役割"医学のあゆみむ. 186. 799-800 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松田敏夫: "アストログリア細胞のアポトーシス"日薬理誌. 112(補冊1). 24-27 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "BQ788, an endothelin ET_B receptor antagonist attenuates stab would injury-induced reactive astrocytes in rat brain"Glia. 26. 268-271 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Endothelin-induced protein tyrosine phosphorylation of cultured astrocytes : It's relationship to cytoskeletal actin organization"Glia. 26. 324-332 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Endothelins stimulate expression of cyclooxygenase 2 in rat cultured astrocytes"J. Neurochem.. 73(3). 1004-1011 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kazuhiro Takuma: "Apoptosis in Ca^<2+> reperfusion injury of cultured astrocytes : roles of reactive oxygen species and NF-kB activation"Eur. J. Neurosci.. 11. 4204-4212 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hitoshi Hashimoto: "Genomic organization and chromosomal location of the mouse vasoactive intenstinal polypeptide 1(VPAC_1) receptor"Genomics. 58(1). 90-93 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 馬場明道: "グリア細胞の活性化とグリア細胞死"最新医学. 54(1). 75-78 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松田敏夫: "グリア細胞の障害と保護"日薬理誌. 114. 281-286 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Transient treatments with L-glutamate and threo-β-hydroxyaspartate induce swelling of rat cultured astrocytes"Neurochem. Int. 36. 167-173 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hitoshi Hashimoto: "Synergistic induction of pituitary adenylate cyclase-activating polypeptide(PACAP) gene expression by nerve growth factor and PACAP in PC12 cells"J. Neurochem.. 74(2). 501-507 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied with their association with cytoskeletal components"Neurosci.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小山豊: "グルタミン酸トランスポーター"蛋白質核酸酵素. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "L-lactate inhibits L-cystine / L-glutamate exchange transport and decreases glutathione content in rat cultured astrocytes"J. Neurosci. Res.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Induction of glutamine synthetase by L-α-aminoadipate in developmental stages of cultured astrocytes."Neurosci. Lett. 223. 65-68 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nobue Ishikawa: "Endothelins promote the activation of astrocytes in rat neostriatum through ETィイD2BィエD2 Receptors."Eur. J. Neurosci.. 9. 895-901 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Rie Hosoi: "Isoform-specific up-regulation by ouabain of NaィイD1+ィエD1, KィイD1+ィエD1- ATPase in cultured rat astrocytes."J. Neurochem. 69(5). 2189-2196 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshio Matsuda: "NaィイD1+ィエD1-CaィイD12+ィエD1 exchanger : physiology and pharmacology."Jpn. J. Pharmacol.. 74(1). 1-20 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shoichi Asano: "Interaction of orally administered 5-{3-[((2S)-1, 4-benzodioxan-2-ylmethyl)amino]propoxy}-1, 3-benzodioxol (MKC-242) with 5-HTィイD21AィエD2 receptors in rat brain."Jpn. J. Pharmacol.. 74(1). 69-75 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shoichi Asano: "Inhibition by nitric oxide of the uptake of [ィイD13ィエD1H] serotonin into rat brain synaptosomes."Jpn. J. Pharmacol.. 75(2). 123-128 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Pranee Somboonthum: "MKC-242, a novel 5-HTィイD21AィエD2 receptor agonist, facilitates cortical acetylcholine release by a mechanism different from that of 8-OH-PAT in awake rats."Neuropharmacology. 36(11-12). 1733-1739 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroyuki Nogi: "Distribution of mRNAs for pituitary adenylate cyclase-activating polypeptide (PACAP), PACAP receptor, vasoactive intestinal polypeptide (VIP), and VIP receptors in the rat superior cervical ganglion."Neurosci. Lett.. 227(1). 37-40 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hitoshi Hashimoto: "Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polyeptide receptor chimeras reveal domains that determine specificity of vasoactive intestinal polypeptide binding and activation."Mol. Pharmacol.. 52(1). 128-135 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroyuki Nogi: "Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor mRNA in the rat adrenal gland : localization by in situ hybridization and identification of splice variants."Jpn. J. Pharmacol.. 75(2). 203-207 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshio Matsuda: "Activation and cell death of astrocytes."Folia Parmacol. Jpn.. 109. 153-159 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masaya Tohyama: "Signal transduction and function of astrocyte."Folia Parmacol. Jpn.. 110. 129-131 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hitoshi Hashimoto: "Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor : structure and functional characterization."Vitamins. 71. 285-296 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kyoko Takahashi: "Effect of taurine on angiotensin II-induced hypertrophy of neonatal rat cardiac cells."J. Cardiovas. Pharmacol.. 30. 725-730 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akemichi Baba: "Role of endothelin B receptor signals in reactive astrocytes."Life Sci.. 62. 1711-1715 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshio Matsuda: "Involvement of calcineurin in CaィイD12+ィエD1 paradox like injury of cultured rat astrocytes."J. Neurochem.. 70(5). 2004-2011 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kyohei Yamamoto: "Cloning and characterization of the mouse pituitary adenylate cyclase-activating polypeptide (PACAP) gene."Gene. 211(1). 63-69 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshio Matsuda: "Response of NaィイD1+ィエD1/CaィイD12+ィエD1 antiporter to ischemia and glial/neuronal death."Folia Parmacol. Jpn.. 111(1). 13-19 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshio Matsuda: "NaィイD1+ィエD1/CaィイD12+ィエD1 exchanger and astroglial cell death."Nokinou-no-Kaimei-21seiki-nimukete. 499-507 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshio Matsuda: "Role of NaィイD1+ィエD1/CaィイD12+ィエD1 antiporter in glial and neuronal death."Igaku-no-Ayumi. 186. 799-800 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshio Matsuda: "Apoptpsis of astroglial cells."Folia Parmacol. Jpn.. 112 (Suppl 1). 24-27 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "BQ788, an endothelin ETィイD2BィエD2 receptor antagonist attenuates stab wound injury-induced reactive astrocytes in rat brain."Glia. 26. 268-271 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Endothelin-induced protein tyrosine phosphorylation of cultured astrocytes : It's relationship to cytoskeletal actin organization."Glia. 26. 324-332 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Endothelins stimulate expression of cyclooxygenase 2 in rat cultured astrocytes."J. Neurochem.. 73(3). 1004-1011 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kazuhiro Takuma: "Apoptosis in CaィイD12+ィエD1 reperfusion injury of cultured astrocytes : roles of reactive oxygen species and NF-kB activation."Eur. J. Neurosci.. 11. 4204-4212 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hitoshi Hashimoto: "Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPACィイD21ィエD2) receptor."Genomics. 58(1). 90-93 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akemichi Baba: "Glial activation and apoptosis."Saishin-Igaku. 54(7). 75-78 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tosio Matsuda: "Cell injury and its protection in astrocytes."Folia Parmacol. Jpn.. 114. 281-286 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Transient treatments with L-glutamate and threo-β-hydroxyaspartate induce swelling of rat cultured astrocytes."Neurochem. Int.. 36. 167-173 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hitoshi Hashimoto: "Synergistic induction of pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression by nerve growth factor and PACAP in PC12 cells."J. Neurochem.. 74(2). 501-507 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied with their association with cytoskeletal components."Neurosci.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "Glutamate transporter."Tanpakusitsu-Kakusan-Kouso. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yutaka Koyama: "L-lactate inhibits L-cystine/L-glutamate exchange transport and decreases glutathione content in rat cultured astrocytes."J. Neurosci. Res.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 馬場明道: "グリア細胞の活性化とグリア細胞死(総説)"最新医学. 54・7. 75-78 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yutaka Koyama: "Endothelins stimulate expression of cyclooxygenase2 in rat cultured astrocytes"J. Neurochem.. 77・3. 1004-1011 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松田敏夫: "グリア細胞の障害と保護(総説)"日本薬理学会雑誌. 114. 281-286 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hitoshi Hashimoto: "Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1( VPAC_1) receptor"Genomics. 58・1. 90-93 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kazuhiro Takuma: "Apoptosis in Ca^<2+> reperfusion injury of cultured astrocytes : roles of reactive oxygen species and NF-κB activation"Eur. J. Neurosci.. 11. 4204-4212 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hitoshi Hashimoto: "Synergistic induction of pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression by nerve growth factor and PACAP in PC12 cells"J. Neurochem.. 74・2. 501-507 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yutaka Koyama: "Transient treatments with-glutamate and threo-β- hydroxyaspartate induce swelling of rat cultured astrocytes"Neurochem. Int.. 36. 167-173 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Toshio Matsuda: "Involvement of calcineurin in Ca^<2+> paradox-like injury of cultured rat astrocytes" J.Neurochem.70. 2004-2011 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松田敏夫: "グリア/ニューロン死におけるNa^+-Ca^<2+>アンチポーターの役割" 医学のあゆみ. 186. 799-800 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yutaka Koyama: "Transient treatment with L-glutamate and threo-b-hydroxaspattate induces swelling of rat cultured astrocytes" Brain Res.(印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yutaka Koyama: "BQ788,an endothelin ETB receptor antagonist attenuates stab wound injury-induced reactive astrocytes in rat brain" Glia. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yutaka Koyama: "Endothelin-induced protein tyrosine phosphorylation of cultured astrocytes: its relationship to cytoskeletal actin organization" Glia. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松田敏夫: "アストロサイトの活性化とグリア細胞死" 日薬理誌. 109. 157-163 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 松田敏夫: "脳虚血へのNa^+-Ca^<2+>アンチポーター応答とグリア/ニューロン死" 日薬理誌. 111. 13-19 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 松田敏夫: "Na^+-Ca^<2+>交換系とアストログリア細胞死" 脳機能の解明-21世紀にむけて-. 499-507 (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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