| Project/Area Number |
09470526
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
応用薬理学・医療系薬学
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
MIYATA Takeshi Faculty of Pharmaceutical Sciences, Department of Pharmacology, Kumamoto University, Professor, 薬学部, 教授 (90040310)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISOHAMA Yoichiro Faculty of Pharmaceutical Sciences, Department of Pharmacology, Kumamoto University, Assistant Professor, 薬学部, 助手 (10240920)
KAI Hirofumi Faculty of Pharmaceutical Sciences, Department of Pharmacology, Kumamoto University, Associate Professor, 薬学部, 助教授 (30194658)
TAKAHAMA Kazuo Faculty of Pharmaceutical Sciences, Department of Hygienic Chemistry, Kumamoto University, Professor, 薬学部, 教授 (80150548)
MIYAMOTO Eishichi Faculty of Medicine, Department of Pharmacology, Kumamoto University, Professor, 医学部, 教授 (50109659)
|
|---|
| Project Period (FY) |
1997 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 1999: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1998: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1997: ¥6,000,000 (Direct Cost: ¥6,000,000)
|
|---|
| Keywords | LYSOZYME / MEF / LUNG / EPITHELIUM / 麦門冬湯 / 肺サーファクタント / 気道 / 咳 / グリシン / 上皮細胞 / リゾチーム / アポトーシス / 肺胞上皮細胞 / 分化 |
|---|
| Research Abstract |
We have published about 20 publications in International Journal. The findings in this study were summarized below.
1. Dextromethorphan inhibited glycine currents in neurons dissociated from the guinea-pig nucleus tractus solitarii.
2. Human neutrophil elastase inhibited tracheala mucociliary transport in anesthetized quails.
3. MEF most strongly stimulated lysozyme transcription in lung epithelial cells (A549), colon carcinoma cells (Caco2), and skin fibroblasts (NIH3T3). These studies provide the first information identifying a transcription factor controlling lysozyme expression in epithelial cells.
4. Maimendongtang improved decreased airway clearance and abnormal secretion.
5. Pulmonary surfactant secretion was regulated by various drugs and endogenous factors in type II pneumocytes.
|
