| Project/Area Number |
09470539
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
KUBO Keishi (1998-1999) School of Medicine, Shinshu University, Professor, 医学部, 教授 (80143965)
小林 俊夫 (1997) 信州大学, 医学部・附属病院, 講師 (80020775)
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| Co-Investigator(Kenkyū-buntansha) |
KOIZUMI Tomonobu University Hospital, Shinshu University, Assistant, 医学部・附属病院, 助手 (20273097)
FUJIMOTO Keisaku University Hospital, Shinshu University, Assistant, 医学部・附属病院, 助手 (70242691)
HONDA Takayuki School of Medicine, Shinshu University, Associate Professor, 医学部, 助教授 (80238815)
HUJII Tadashige School of Allied medical Science, Shinshu University, Professor, 教授 (50020780)
蜂谷 勤 信州大学, 医学部附属病院, 助手 (20303464)
久保 恵嗣 信州大学, 医学部, 講師 (80143965)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1999: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1998: ¥4,200,000 (Direct Cost: ¥4,200,000)
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| Keywords | High-altitude pulmonary edema / Individual difference / HLA analysis / Bronchoalveolar lavage / Pulmonary artery remodeling / Pulmonary hypertension / Exercise / 肺MAC症 / 肺動脈圧 / 高山病 / HLA-typing / ANP / 2,3-DPG / 肺水腫 / 高地 / HLA / 低酸素換気応答能 / 肥満細胞 / 右室肥大 / 低酸素 |
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| Research Abstract |
We have performed the following 4 projects under the grant.
(1) Analysis of human leukocyte antigen (HLA) alleles in high-altitude pulmonary edema (HAPE): We analyzed the frequencies of HLA alleles in 30 subjects with a history of HAPE, comparing with those in 100 bealthy controls. There were significantly associations of HAPE with HLA-DR6 and HLA-DQ4 and of pulmonary hypertension with HLA-DR6.
(2) Analysis of HLA alleles in Mycobacterium avium-intracellulare (MAI) pulmonary infection: We evaluated the frequencies of HLA alleles in 64 cases of MAI disease, showing deterioration in 27 and no deterioration in 37 subjects after an interval of 30 ± 15 months. The subjects with HLA A-26 antigens might indicate the deterioration of MAI pulmonary infection.
(3) Analysis of bronchoalveolar lavage (BAL) fluid in patients with HAPE: During the early stage of HAPE the total cell counts, neutrophils and lymphocytes in the BAL fluid were significantly increased compared with those at the recovery and in healthy controls. Furthermore, the BAL fluid levels of total protein, LDH, IL-1β, IL-6, IL-8 and TNF-α were significantly elevated.
(4) Pulmonary artery remodeling and pulmonary hypertension: The pika (Ochotona curzoniae), a family of rodent adapted to high altitude, has a lower response of pulmonary vasoconstriction to hypoxia and thin-walled pulmonary arteioles. In 10 patients with severe emphysema who underwent lung volume reduction surgery the wall thickness (WT) of small pulmonary artery was significantly increased (27.5 ± 4.5 μm) compared with that (16.5 ± 42.8 μm). The percent WT of the external diameter was not related to Ppa at rest, but was highly correlated with exercise Ppa.
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