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PREPARATION OF NOVEL BIOMEDICAL POLYMERS HAUING BIOMEMBRANE-LIKE SURFACE AND RECOGNITION OF THEIR NON THROMBOGENIC

Research Project

Project/Area Number 09480250
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTHE UNIVERSITY OF TOKYO (1998-2000)
Tokyo Medical and Dental University (1997)

Principal Investigator

ISHIHARA Kazuhiko  THE UNIVERSITY OF TOKYO, DEPARTMENT OF MATERIAL SCIENCE, PROFESSOR, 大学院・工学系研究科, 教授 (90193341)

Co-Investigator(Kenkyū-buntansha) IWASAKI Yasuhiko  TOKYO MEDICAL AND DENTAL UNIVERSITY, INSTITUTE OF BIOMATERIALS AND BIOENGINEERING, ASSOCIATE PROFESSOR, 生体材料工学研究所・素材部門, 助教授 (90280990)
渡辺 昭彦  東京医科歯科大学, 医用器材研究所, 助手 (30126263)
田中 志信  山形大学, 工学部, 助教授 (40242218)
Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1997: ¥4,100,000 (Direct Cost: ¥4,100,000)
KeywordsBIOMEMBRANE-LIKE STRACTURE / BIOMEDICAL POLYMER / BLOOD COMPATIBILITY / MPC POLYMER / PLATELET ADHESION / PROTEIN ADSORPTION / FREE WATER / SURFACE / 材料化学的特性 / リン脂質極性基 / 血小板の機能 / 医用材料 / 生体適合性ポリマー / リン脂質ポリマー / 自己組織化 / 細胞粘着
Research Abstract

Novel polymer biomaterials, which can use in contact with blood, are prepared with strong inspiration from the surface structure of biomembrane. That is, the polymers with phospholipid polar group in the side chain, 2-methacrylooyloxyethyl phosphorylcholine (MPC) polymers were synthesized. The MPC polymers can inhibit surface-induced clot formation effectively, even when they contact with blood in the absence of anticoagulant. This phenomenon was due to reduction of plasma protein and suppression of denaturation of adsorbed proteins. That is, the MPC polymers interact with blood components very mildly.
The amount of protein adsorbed on the polymer surface had a close relation to the free water fraction in the hydrated polymer. A comparison of the conformational change in proteins adsorbed on the MPC polymers and poly (HEMA) revealed that the effectiveness of the phosphorylcholine group in preventing the change, and the protein on the MPC polymer maintained its original state. Thus, it is concluded that the free water fraction is one of the most important factors in controlling the protein adsorption process.
As the molecular structure of the MPC polymer was easily designed by changing monomer units and composition, it could apply to surface modification of artificial organs and biomedical devices for improving blood compatibility and tissue compatibility. Thus, the MPC polymers are useful polymer biomaterials for making high performance artificial organs and biomedical devices to provide safety medical treatments.

Report

(5 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] T.Yoneyama,M.Ito,Y.Iwasaki K.Ishihara,N,Nakabayashi: "Small-Diameter rascular Prostheis with a Nonthrombogenic Phospholipid Polymer Surface."Artf.Organs. 24・1. 23-28 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Ishihara,Y.Iwasaki S.Ebihara,N.Nakabayashi: "Photo-induced Graft Polymerization of 2-methacryloyloxyethyl Phosphorylcholine on Polyethylene Membrane Surface"Colloid and Surfaces B : Biointerfaces. 18. 325-335 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Ishihara: "New Polymeric Biomaterials-Phospholopid Polymers with Biocompatible Surface"Frantiers Med,Biol.Engng. 10・2. 83-95 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 石原一彦: "生体構造に啓発されたポリマーバイオマテリアルの創製"生体材料. 18・1. 33-40 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 石原一彦: "バイオミメティックハンドブック"長田、甲斐、嘉数、片岡、酒井、田中 編エス・ティー・エス. (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.YONEYAMA, M.ITO, Y.IWASAKI K.ISHIHARA, N.NAKABAYASHI: "SMALL-DIAMETER VASCULAR PROSTHEIS WITH A NONTHROMBOGENIC PHOSPHOLIPID POLYMER SURFACE"ARTIF ORGANS. 24 1. 23-28 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.ISHIHARA, Y.IWASAKI, S.EBIHARA, N.NAKABAYASHI: "PHOTOINDUCED GRAFT POLYMERIZATION OF 2-METHACRILOYLOXYETHYL PHOSPHORYLCHOKINE ON POLYECHYLENE MEMBRANE SURFACE"COLLOID AND SURFACE B : BIOINTERFACES. 18. 325-335 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.ISHIHARA: "NEW POLYMERIC BIOMATERIALS-PHOSPHOLIPID POLYMERS WITH A BIOCOMPATIBLE SAFACE"FRONTIERS MED.BIOL.ENGNG. 10 2. 83-95 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.ISHIHARA: "PREPARATION OF BIOINSPIRED BIOMEDICAL POLYMER"SEITAI ZAIRYO. 18. 33-40 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Yomeyama,M.Ito,Y.Iwasaki K.Ishihara,N.Nakabayashi: "Small-Diameter Vascular Prostheis with a Nonthrombogenic Phospholipid Polymer Surface"Artf.Organs. 24・1. 23-28 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Ishihara,Y.Iwasaki,S.Ebihara,N.Nakabayashi: "Photo induced Graft Polymerization of 2-Methacrylcyloxyethyl Phosphorylcholine on Polyethylene Membrane Surface"Colloid and Surfaces B:Biointerfaces. 18. 325-335 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Ishihara: "New Polymeric Biomaterials-Phospholipid Polymers with Biocompatible Surface"Frontiers Med.Biol.Engng. 10・2. 83-95 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 石原一彦: "生体構造に啓発されたポリマーバイオマテリアルの創製"生体材料. 18・1. 33-40 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 石原一彦: "バイオミメティックハンドブック"長田,甲斐,嘉数,片岡,酒井,田中 編エヌ・ティー・エス. (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y. Iwasaki, M. Ijuin, A. Mikami, N. Nakabayashi, and K. Ishihara: "Behavior of Blood Cells in Contact with Water-soluble Phospholipid Polymer"J. Biomed. Mater. Res.. 46. 360-367 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y. Iwasaki, S. Sawada, N. Nakabayashi, G. Khang, H. B. Lee and K. Ishihara: "The Effect of Chemical Structure of the Phospholipid Polymer on Fibronectin Adsorption and Fibroblast Adhesion on the Gradient Phospholipid Surface"Biomaterials. 20・22. 2185-2191 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K. Ishihara, E. Ishikawa, Y. Iwasaki, and N. Nakabayashi: "Inhibition of Cell Adhesion on the Substarate by Coating with 2-Methacryloyloxyethy1 Phosphorylcholine Polymers"J. Biomater. Sci., Polymer Edn.. 1010. 1047-1061 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.Ishihara,Y.Iwasaki: "Reduced Protein Adsorption on Novel Phospholipid Polymers" J.Biomat.Appl.13. 111-127 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 河野秀之,栗田公夫,岩崎泰彦,石原一彦,中林宣男: "種々の水溶性ポリマーをグラフト化したセルロース血液透析膜表面の血液適合性" 高分子論文集. 55・6. 334-343 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Ishihara: "ADVANCES IN POLYMERIC BIOMATERIALS SCIENCE" T.Akaike, T.Okano, M.Akashi, M.Terano, N.Yui, 686 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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