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Design of Extracellular Space

Research Project

Project/Area Number 09480260
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKYUSHU UNIVERSITY (1998-1999)
National Cardiovascular Center Research Institute (1997)

Principal Investigator

MATSUDA Takehisa  Dept. Bioengineering, Graduate of School of Medicine, Kyushu University, Professor, 大学院・医学系研究科, 教授 (60142189)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Yasuhide  Department of Bioengineering, National Cardiovascular Center, Research Institute, 生体工学部, 室長 (50250262)
増田 慎介  国立循環器病センター研究所, 生体工学部, レジデント研究員
高見沢 計一  国立循環器病センター研究所, 生体工学部, 室員 (10163312)
中谷 武嗣  国立循環器病センター研究所, 生体工学部, 室長 (60155752)
関 淳二  国立循環器病センター研究所, 生体工学部, 室長 (20163082)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥10,300,000 (Direct Cost: ¥10,300,000)
KeywordsTissue Engineering / Extracellular Matrix / Biomaterial / Surface Design / 心筋 / 組織工学 / 人工細胞外マトリックス / 力学ストレス場 / 組織化 / 細胞外環境設計
Research Abstract

This project was focused to design etxtracellular matrices and to fabricate three-dimensional tissues architecture. The design based on novel biomaterials, surface designs and fabrication process designs have been developed. These designs based on new disciplines have been consolidated to form functional hybrid tissues such as vessels and muscles. Thus, the study provided solid basis of the design criteria and tissue-engineering functional tissues.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Y. Nakayama and T. Matsuda: "Photocurable Surgical Tissue Adhesive Glues Composed Photoreactive…"J. Biomed Mater Res (Appl Biomater). 48. 511-521 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T. Matsud, R.E., Marchant, J. Higashi, Y. Nakayama: "High-Spatioresolved Microarchitectual Surface Surface Parpared by …"Langmuir. 15. 2080-2088 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Nakayama, M. Miyamura, Y. Hirano, Goto, T. Matsuda: "Preparation of poly(ethylence glycol)-polystyrene block copolymers…"Biomaterials. 20. 963-970 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N. Saito, T. Matsuda: "Protain adsorption on self-assembled monolayers with…"Materials Science & Engineering. C6. 261-266 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Nakayama, T. Matsuda: "In Situ Observation of Dethiocarbomate-Based Surface Photograft…"Macromolecules. 16. 5405-5410 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Nakayama and Takehisa Matsuda: "Photocurable Surgical Tissue Adhesive Glues Composed of Photoreactive Gelatin and Poly (ethylene glycol) Diacrylate"J. Biomed. Mater. Res (Appl Biomater). 48. 511-521 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J. Higashi, Y. Nakayama, R. E. Marchant, and T. Matsuda: "High-Spatioresolved Microarchitectual Surface Prepared by Photograft Copolymerization Using Dithiocarbamate : Surface Preparation and Cellular Response"Langmuir. Vol. 15, No. 6. 2080-2088 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Nakayama, M. Miyamura, Y. Hirano, K. Goto, T. Matsuda: "Preparation of Poly (ethylene glycol)-Polystyrene block copolymers using photochemistry of dithiocarbamate as a reduced cell-adhesive coating material"Biomaterials. 20. 963-970 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Noboru Saito, Takehisa Matsuda: "Protein adsorption on self-assembled monolayers with water-soluble non-ionic oligomers using quartz crystal microbalance"Materials Science & Engineering. C6. 261-266 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Nakayama and T. Matsuda: "In Situ Observation of Dethiocarbamate-Based Surface Photograft Copolymazation Using Quartz Crystal Microbalance"Macromolecules. Vol. 32, No. 16. 5405-5410 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Nakayama and T. Matsuda: "Photocurable Surgical Tissue Adhesive Glaues Composed Photoreactive...."J. Biomed Mater Res(Appl Biomater). 48. 511-521 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T. Matsuda, R.. E, Marchant J. Higashi, Y. Nakayama: "High-Spatioresolved Microarchitectual Surface Prepared by..."Langmuir. 15. 2080-2088 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y. Nakayama, M. Miyamura, Y. Hirano, K. Goto, T. Matsuda: "Preparation of poly(ethylene glycol)-polystyrene block copolymers...."Biomaterials. 20. 963-970 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] N. Saito, T. Matsuda: "Protain adsorption onself-assembled monolayers with ...."Materials Science & Engineering. C6. 261-266 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y. Nakayama, T. Matsuda: "In Situ Observation of DethioCarbomate-Based Surface Photograft...."Macromolecules. 16. 5405-5410 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Heung Jae Lee Talcehisa Matsuda: "Surface photgraft polymerization on Segmented ..."Journal of Biomedial Materials Recearch. 47. 564-567 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Heung. J Lee, Y. Nakayama, T. Matsuda: "Spatio-Resolved, Macromolecular Architectural ...."Macromolecules. 32. 6985-6995 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Okano and T.Matsuda: "Tissue Engineered Skelet al Musele:Preparation of Highly Dense,Highly Oriented Hybrid Muscular Tissues" Cell Transplantation. 7・1. 71-82 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Nakayama,K.Nakamoto Y.Hiorano,K.Goto,andT.Matsuda: "Surface Hydrogelation of thiolated watex-Soluble Copolymers on Bold" Langmuir. 14・14. 3909-3915 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Okano and T.Matsuda: "Muscular Tissue Enginering:Capillary-Incorporated Hybrid Muscular Tissue Culture" Cell Transplantation. 7・5. 435-442 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kiyoshi Doi and Takehisa Matsuda: "Enhanced vascularization in a microporous polyurethane graft impregnated with basic fibrolastgrouwth factor and heparin" Jounal of Biomedical Materials Research. 34. 361-370 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masami Tanahashi and Takehisa Matsuda: "Surface functional group dependence on apatite foumation on self-assembled monolayers in a simulated body fluid" Jounal of Biomedical Material Recearch. 34. 305-315 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takahisa Okano and Takehisa Matsuda: "Hybrid Muscular Tissues:Preparation of Skeletal Muscle Cell-Incorporated Collagen Gels" Cell Transplantation. 6,2. 109-118 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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