| Project/Area Number |
09555128
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
計測・制御工学
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
ENPUKU Keiji Kyushu Univ., Graduate School of Information Science and Electrical Engineering, Associate Prof., 大学院・システム情報科学研究科, 助教授 (20150493)
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| Co-Investigator(Kenkyū-buntansha) |
CHINONE Kazuo Seiko Instrument, 技術総括部, 課長
YOSHIDA Keiji Kyushu Univ., Graduate School of Information Science and Electrical Engineering, Prof., 大学院・システム情報科学研究科, 教授 (80108670)
KISS Takanobu Kyushu Univ., Graduate School of Information Science and Electrical Engineering, Associate Prof., 大学院・システム情報科学研究科, 助教授 (00221911)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1998: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1997: ¥7,700,000 (Direct Cost: ¥7,700,000)
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| Keywords | SQUID magnetometer / SQUID microscope / magnetic nanoparticles / immunoassays / magnetic marker / high Tc superconductor / 1 / f noise / 30-degree bicrystal junction / SQUID / 磁気センサ / ジョセフソン素子 / バイクリスタル基板 / ノイズ / 磁束ノイズ |
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| Research Abstract |
In this research, we developed high Tc SQUID magnetic-microscope system for biological application. Our results are summarized as follows.
1. We developed high performance SQUID utilizing bicrystal junctions with 30-degree misorientation angles. At 77 K, we can routinely obtain the voltage modulation depth ΔV>20μV and the flux noise SィイD2φィエD2ィイD11/2ィエD1<12μφィイD2oィエD2/HzィイD11/2ィエD1 for 100pH-SQUID.
2. We significantly reduced the 1/f noise of the direct-coupled magnetometer. In order to avoid the flux trapping in the pickup coil, we develop a pickup coil which consists of 4 parallel loop with narrow line-width and involves the so-called flux dam. With this pickup coil, the flux noise is reduced to SィイD2φィエD2ィイD11/2ィエD1=23μφィイD2oィエD2/HzィイD11/2ィエD1 at f=1 Hz. This values is only 2.3 times higher than the white noise of SィイD2φィエD2ィイD11/2ィエD1=10μφo/HzィイD11/2ィエD1.
3. We developed a SQUID microscope system in order to detect FeィイD22ィエD2OィイD23ィエD2 magnetic nanoparticles. A special Dewar to make a distance between the SQUID and sample as small as 1 mm is developed. The system works well even when the magnetic field of 10 Gauss is applied in parallel to the SQUID.
4. Biological immunoassay is performed with the present system. In the present system, as antibody is labeled with FeィイD22ィエD2OィイD23ィエD2 nanoparticles. Binding reaction between antigen and its antibody can be detected by measuring the magnetic field from FeィイD22ィエD2OィイD23ィエD2 nanoparticles. It is shown that the present system is 10 times more sensitive than the conventional method using an optical marker. It will be possible to improve the sensitivity by more than factor 10.
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