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Establishment of Fundamental Technique of Electrode Surface Modification for Development on Molecularly Imprinted Sensor

Research Project

Project/Area Number 09555265
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 工業分析化学
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

TAKAGI Makoto  Grad. Sch. of Eng., Kyushu University, Professor, 大学院・工学研究科, 教授 (90037739)

Co-Investigator(Kenkyū-buntansha) TAZAKI Masato  Kumamoto Inst. of Tech., Fac. of Eng., Kyushu University, Associate Professor, 工学部, 助教授 (40112304)
NAKAMURA Shigeru  Grad. Sch. of Eng., Kyushu University, Assistant Professor, 大学院・工学研究科, 助手 (00264078)
NAKANO Koji  Grad. Sch. of Eng., Kyushu University, Associate Professor, 大学院・工学研究科, 助教授 (10180324)
浅野 泰一  電気化学計器(株), 開発本部, 研究員
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1997: ¥6,100,000 (Direct Cost: ¥6,100,000)
Keywordsmolecular imprinting / sensor / gold electrode / molecular recognition / polymer membrane
Research Abstract

In recent years, sensor for selective detection of target molecular is developed. We have developed a new method of molecular imprinting, and have been trying to apply the method to sensor.
We started with a basic investigation of the structure of molecularly imprinted resin surface. The broadening of pKa was observed from proton titration of the resin. This results suggests the strong interaction between the functional groups and it is evidence that the carboxyl groups exist two dimensionally.
Formation of Self-assembled monolayer from alkaneselenol and electrochemical characterization of the modified electrode were investigated. Alkaneselenol absorb to gold electrode more strongly than corresponding alkanethiol. It should be understood from the fact that selenium is a softer ligand than sulfur and has high affinity to class B metal such as gold and silver.
We tried an application to the membrane electrode-type ion sensor as a method for evaluation of imprinting effect. Molecular imprinting membrane was prepared by the polymerization after permeation of the salt of functional monomer and organic cation into the membrane. This ion sensing membrane effectively responded to the template ion, but it was not perfect Nernstian response.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] 中野幸二: "自己組織化単分子膜による化学修飾電極"日本接着学会誌. 33. 240-247 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Koide: "Adsorption of Metal Ions to Surface-Template Resins Prepared with Amphiphilic Styrene Monomers Bearing Amino Carboxylic Acid"Bull. Chem. Soc. Jpn.. 71. 789-796 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Tsukagoshi: "Surface Imprinting: Preparation of Metal Ion-Imprinted Resins by Use of Complexation at the Aqueous-Organic Interface"ACS SYMPOSIUM SERIES. 703. 251-263 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中野幸二: "自己組織化単分子膜を用いるタンパク質固定化電極の調製と電気化学インピーダンス測定及び赤外分光測定によるキャラクタリゼーション"分析化学. 47. 929-935 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Yoshida: "An Enantioselective Polymer Polymer Prepared by the Surface Molecular-Imprinting Technique"Chem. Lett.. 925-926 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Koide: "Selective Adsorption of Metal Ions to Surface-Templated Resins Prepared by Emulsion Polymerization Using a Functional Surfactant"ACS SYMPOSIUM SERIES. 703. 264-277 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T. Miyajima: "A Physicochemical Study on thr Origin of the Imprinting Effect"ACS SYMPOSIUM SERIES. 703. 290-297 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S. Nakamura: "Molecularly Imprinted Resin for Recognition of Amino Acids Using Self-Assembly at o/w Interface"Trang. MRS-J.. 24. 453-456 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Nakano: "Calix[n]arenes Provided with Thiols for Modified Electrode Applications; Ring-Size Dependent Voltammetric Behavior Toward Ferrocene Derivatives"Chem. Lett.. 60-61 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Nakano: "Self-Assembled Monolayer Formation from Decaneselenol on Polycrystalline Gold as Characterized by Electrochemical Measurements, QCM, XPS and IR Spectroscopy"Langmuir. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Tazaki: "Synrhesis of extra pure 11-amino-1-undecanethiol hydrochloride"Sulfur Letters. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Nakano: "DNA-Modified Electrode. Molecular Recognition of DNA and Biosensor Applications"A. G. Volkov Ed, "Liquid Interfaces in Chemical, Biological, and Pharmaceutical applications", Marcel Dekker, New York. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Nakano: "Self-Assembled Monolayer for Chemically Modified Electrode Application"Nihon Secchaku Gakkaishi. 33. 240-247 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Koide, et al.: "Adsorption of Metal Ions Surface-Template Resins Prepared with Amphiphilic Styrene Monomers Bearing Amino Carboxylic Acid"Bull. Chem. Soc. Jpn. 71. 789-796 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Yoshida et al.: "An Enantioselective Polymer Prepared by the Surface Molecular-Imprinting Technique"Chem. Lett.. 925-926 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Tsukagoshi et al.: "Surface Imprinting : Preparation of Metal Ion-Imprinting Resins by Use of Complexation at the Aqueous-Organic Interface"ACS SYMPOSIUM SERIES. 703. 251-263 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Koide, et al.: "Selective Adsorption of Metal Ions Surface-Template Resins Prepared by Emulation Polymerization Using a Functional Surfactant"ACS SYMPOSIUM SERIES. 703. 264-277 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T. Miyajima et al.: "A Physicochemical Study on the Origin of the Imprinting Effect"ACS SYMPOSIUM SERIES. 703. 290-297 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Nakano et al.: "Covalent attachment of proteins on self-assembled monolayer electrodes as characterized by electrochemical impedance measurements and FT-IR spectroscopy"BUNSEKI KAGAKU. 47. 929-935 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S. Nakamura et al.: "Molecular Imprinting Resin for Recognition of Amino Acids Using Self-Assembly at o/w Interface"Trans. MRS-J.. 24. 453-456 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Nakano et al.: "Calix[n]arenes Provided with Thiols for Modified Electrode Applications ; Ring-Size Dependent Voltammetric Behavior Toward Ferrocene Derivatives"Chem. Lett.. 60-61 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Nakano et al.: "Self-Assembled Monolayer Formation from Decaneselenol Polycrystalline Gold as Characterized by Electrochemical Measurements. QCM, XPS and IR Spectroscopy"Langmuir. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Tazaki et al.: "Synthesis of extra pure 11-amino-1-undecanethiol hydrochloride"Sulfur Letters. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Nakano: "DNA-Modified Electrode. Molecular Recognition of DNA and Biosensor Applications"A. G. Volkov Ed, "Liquid Interfaces in Chemical, Biological, and Pharmaceutical Applications", Marcel Dekker, New York (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.Nakamura: "Molecularly Imprinted Resin for Recognition of Amino Acids Using Self-Assembly at o/w Interface"Transaction of Materials Research Society of Japan. 24(3). 453-456 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.Nakano: "Calix[n]arenes Provided with Thiols for Modified Electrode Applications; Ring-Size Deperdent Voltammetric Behavior Toward Ferrocene Derivative"Chemistry Letters. (1). 60-61 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.Nakano: "Salf-Assembled Monolayer Formation from Decaneselenol on Polycrystalline Gold as Characterizied by Electrochemical Neasurements, QCM,XPS and IR Spectroscopy"Langmuir. in press.

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Tazaki: "Synthesis of Extra Pure II-Amino-I-undecanethiol Hydrochloride"Sulfur Letters. in press.

    • Related Report
      1999 Annual Research Report
  • [Publications] 中野 幸二: "自己組織化単分子膜による化学修飾電極" 日本接着学会誌. 33・6. 240-247 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Toshihiro Ihara: "Gene Sensor Using Ferrocenyl Oligonucleotide" J.Chem.Soc.,Chem.Commun.17. 1609-1610 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Koji Nakano: "Bioaffinity Sensor Using Oligonucleotide-Modified Au Electrode" Aual.Sci.13. 455-456 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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