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Development of hypoallergenic soybean products and evaluation of their availability

Research Project

Project/Area Number 09556028
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 食品科学・栄養科学
Research InstitutionKYOTO UNIVERSITY (1998)
The University of Tokushima (1997)

Principal Investigator

OGAWA Tadashi  KYOTO UNIVERSITY,Research Institute for Food Science ; Professor, 食糧科学研究所, 教授 (80027193)

Co-Investigator(Kenkyū-buntansha) HOSOYAMA Hiroshi  Allergen Free Technology Co., Researcher, テクノロジー研究所, 研究員
BANDO Noriko  The Tokushima University, School of Medicine, Technician, 医学部, 教務員 (40116851)
MORIYAMA Tatsuya  KYOTO UNIVERSITY,Research Institute for Food Science ; Assistant professor, 食糧科学研究所, 助手 (60239704)
山西 倫太郎  徳島大学, 医学部, 助手 (30253206)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥5,500,000 (Direct Cost: ¥5,500,000)
Keywordssoybean / allergen / hypoallergenic / allergic patients / challenge test / chemical breeding / 低アレルゲン煮豆 / 低アレルゲン豆腐 / 低アレルゲン大豆プリン / 食物アレルギー
Research Abstract

Soybean are known as one of the major allergenic foodstuffs, while they have been recognized to be the important protein sources in a field food processing because of their nutritional and functional benefit. At the present day, there is an urgent demand on food scientist to identify the proteins responsible for the allergenicity and to develop the hypoallergenic soybean products for soybean allergic patients, because there is no effective thereputic meenings other than the elimination of offending foodstuffs.
The reduction of allergenicity of soybean and soybean products has been done by using the techniques of breeding, physicochemical treatments, and enzymatic digestion. Among three major allergens, alpha-subunit of beta-conglicinin and Gly mBd 28K were eliminated from seeds by a chemical breeding, and the most strong one, Gly m Bd 30K, was almost completely removed from soymilk by a centrifugation under limited conditions. By the combination of these procedures, several hypoallergenic soybean products were developed and subjected to a challenge test with soybean allegic patients to evaluate its efficacy. The results demonstrated that the cooked soybean treated with Bacillus proteinase may be effective for about 80% of the soybean allergic patients.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] T.Ogawa: "Substantially Complete Removal of Three Major Allergenic Soybean Protein(Gly m Bd 30K, Gly m Bd 28K, and α-Subunit of β-Conglycinin) from Soy Protein by Using a Mutant Soybean, Tohoku 124." Biosci.Biotech.Biochem.,. 61,. 2148-2150 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Ogawa: "Effect of Polysaccharide Conjugation or Transglutaminase Treatment on the Allergenicity and Functional Porperties of Soybean Protein." J.Agr.Food Chem.,. 46,. 866-871 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Ogawa: "Fate of a Major Soybean Allergen, Gly m Bd 30K, in Rice-, Barley-, and Soybean- Koji Miso(Fermented Soybean Paste) during Fermentation." Food Sci.Technol.Int.Tokyo,. 3,. 145-149 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Ogawa: "Micro-Assay Method for Evaluating the Allergenicity pg the Major Soybean Allergen, Gly m Bd 30K, with Mouse Antiserum and RBL-2H3 Cells." Biosci.Biotech.Biochem.,. 61,. 19-23 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Ogawa: "Purification and Characterization of Soybean Allergen Gly m Bd 28K." Biosci.Biotech.Biochem.,. 61,. 942-947 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Ogawa et al.: "Substantially Complete Removal of Three Major Allergenic Soybean Protein(Gly m Bd 30K,Gly m Bd 28K,and alpha-Subunit of beta-Conglycinin)from Soy Protein by Using a Mutant Soybean, Tohoku 124." Biosci.Biotech.Biochem.61. 2148-2150 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Ogawa et al.: "Purification and Characterization of Soybean Allergen Gly m Bd 28K." Biosci.Biotech.Biochem.61. 942-947 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Ogawa et al.: "Micro-Assay Method for Evaluating the Allergenicity pg the Major Soybean Allergen, Gly m Bd 30K,with Mouse Antiserum and RBL-2H3 Cells." Biosci.Biotech.Biochem.61. 19-23 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Ogawa et al.: "Fate of a Major Soybean Allergen, Gly m Bd 30K,in Rice-, Barley-, and Soybean- Koji Miso(Fermented Soybean Paste)during Fermentation." Food Sci.Technol.Int.Tokyo. 3. 145-149 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Ogawa.: "Effect of Polysaccharide Conjugation or Transglutaminase Treatment on the Allergenicity and Functional Porperties of Soybean Protein." J.Agr.Food Chem.46. 866-871 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Ogawa: "Substantially Complete Removal of Three Major Allergenic Soybean Protein (Gly m Bd 30K,Gly m Bd 28K,and α-Subunit of β-Conglycinin) from Soy protein by Using a Mutant Soybean,Tohoku 124" Biosci.Biotech.Biochem.,. 61. 2148-2150 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Ogawa: "Effect of Polysaccharide Conjugation or Transglutaminase Treatment on the Allergenicity and Functional Porperties of Soybean Protein." J.Agr.Food Chem.,. 46. 866-871 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Ogawa: "Fate of a Major Soybean Allergen,Gly m Bd 30K,in Rice-,Barley-,and Soybean-Koji Miso (Fermented Soybean Paste) during Fermentation." Food Sci.Technol.Tokyo. 3. 145-149 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Ogawa: "Micro-Assay Method for Evaluating the Allergenicity pg the Major Soybean Allergen,Gly m Bd 30K,with Mouse Antiserum and RBL-2H3 Cells." Biosci.Biotech.Biochem.61. 19-23 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Ogawa: "Purification and Characterization of Soybean Allergen Gly m Bd 28K" Biosci.Biotech.Biochem.61. 942-947 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] B.Yanishi: "Micro-assay method for evaluating the allergenicity of the major soybean allergen,Gly m Bd 30K" Biosci.Biotech.Biochem.61. 19-23 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Tuji: "Fate of a major soybean allergen,Gly m Bd 30K in rice-,barley,and soybean miso during fermentation." Food Sci.Technol.Int.Tokyo. 3. 157-162 (197)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Tsuji: "Purification and characterzation of soybean allegen Gly m Bd 28K" Biosci.Biotech.Biochem.61. 942-947 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Samoto: "Substantially complete removal of three major allergenic soybean proteins" Biosci.Biotech.Biochem.61. 2148-2150 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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