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Development of Analysis Method of Immune Surveillance System in Various Animals by using Adenovirus Vector.

Research Project

Project/Area Number 09556066
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section展開研究
Research Field Applied veterinary science
Research InstitutionThe University of Tokyo

Principal Investigator

KAI Chieko  LABORATORY ANIMAL RESEARCH CENTER, INSTITUTE OF MEDICAL SCIENCE, THE UNIVERSITY of TOKYO, 医科学研究所, 教授 (10167330)

Co-Investigator(Kenkyū-buntansha) AIDA Yoko  RIKEN TSUKUBA INSTITUTE, ライフサイエンス筑波研究センター, 研究員 (50182994)
KOFUNE Tomio  DEPARTMENT OF PATHOLOGY, NATIONAL INSTITUTE OF HEALTH AND WELFARE, 病理部, 主任研究官 (80142644)
SAITO Izumu  LABORATORY OF MOLECULAR GENETICS, INSTITUTE OF MEDICAL SCIENCE, THE UNIVERSITY OF TOKYO, 医科学研究所, 教授 (70158913)
YAMANOUCHI Kazuya  NIPPON INSTITUTE FOR BIOLOGICAL SCIENCE, 研究部, 主任研究員 (30072888)
宮沢 孝幸  東京大学, 大学院・農学生命科学研究科, 助手 (80282705)
Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2000: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1997: ¥3,600,000 (Direct Cost: ¥3,600,000)
Keywordsadenovirus / canine distemper / CDV / H protein / CTL / アデノイルス / 牛疫 / 細胞性免疫 / ウシ白血病ウイルス / MHC / 牛疫ウイルス / ウサギ / 細胞傷害試験 / 組み換えアデノウイルス / lacZ / 牛白血病ウイルス / ウシ
Research Abstract

The AIM of this research is the development of analysis method of immune surveillance system in various animals by using adenovirus vector to characterize cell mediated immunity surveillance system. The various results were obtained, as followings,
(1) We established the recombinant adenovirus vector encoding canine distemper virus (CDV) hemagglutinin (H) gene. We also established the method to get primary dog skin cells for the target of cytotoxic T lymphocyte (CTL) assay. It makes us possible to get the targeted cells from self-animals.
(2) We identified epitopes for cell-mediated immunity and humoral immunity in N protein of rinderpest virus. By utilizing immune-stimulating complex (ISCOM), recombinant H protein was revealed to be effective in cell mediated immunity.
(3) We identified the resistant Major Histocompatibility Complex (BoLA) class II molecules to the bovine leukemia ; BoLA-DR3 allele. The recombinant adenovirus encoding BLV genome

Report

(5 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (165 results)

All Other

All Publications (165 results)

  • [Publications] Shin,Y.-S., et al.: "Expression of the nucleocapsid protein gene of the canine distemper virus."J.Vet.Med.Sci.. 59. 51-53 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Iwatsuki, et al.: "Molecular and phylogenetic analyses of the haemagglutinin proteins of field isolates from dogs naturally infected with canine distemper virus."J.Gen.Virol.. 78. 373-380 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okita,M., et al.: "Histopathological features of canine distemper recently observed in Japan."J.Comp.Pathol.. 116. 403-408 (1997)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Uetsuki,K., et al.: "Protective effects of a novel quinine derivative, E3330, on mouse hepatitis virus (MHV)-induced chronic hepatitis in athymic nude mice."Exp.Anim.. 46. 219-223 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shimojima,Y., et al.: "Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the herpes simplex virus type 1 glycoprotein H."J.Vet.Med.Sci.. 59. 629-634 (1997)

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      2000 Final Research Report Summary
  • [Publications] Ikeda Y, et al.: "The effects of treatment with chemical agents or infection with feline viruses on protein-binding properties of the feline immunodeficiency virus long terminal repeat."Virus Res. 51. 203-12 (1997)

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      2000 Final Research Report Summary
  • [Publications] Nakamura,K., et al.: "Immunization of rabbits against systemic rinderpest virus infection by vaccinia virus expressing the nucleoprotein of rinderpest virus."Comp.Immunol.Microbiol.Infect.Dis.. 21. 91-99 (1998)

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      2000 Final Research Report Summary
  • [Publications] Ohishi,K., et al.: "Construction of recombinant vaccinia virus expressing rinderpest virus nucleocapsid protein and its immunogenicity in mice."J.Vet.Med.Sci.. 60. 655-656 (1998)

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      2000 Final Research Report Summary
  • [Publications] Ikeda, et al.: "Protein-binding of the putative AP-1 and ATF sequences in the feline immunodeficiency virus long terminal repeat."J.Gen.Virol.. 79. 95-99 (1998)

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      2000 Final Research Report Summary
  • [Publications] Mario,A., et al.: "Nucleotide sequence of the genes encoding glycoproteins I and E of equine herpesvirus type 4."J.Vet.Med.Sci.. 60. 219-225 (1998)

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      2000 Final Research Report Summary
  • [Publications] Iwatsuki,K., et al.: "The nucleotide and predicted amino acid sequence of the fusion protein of recent isolates of canine distemper virus in Japan."J.Vet.Med.Sci.. 60. 381-385 (1998)

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      2000 Final Research Report Summary
  • [Publications] Yoshida,E., et al.: "Molecular analysis of the nucleocapsid protein of recent isolates of canine distemper virus in Japan."Vet.Microbiiol.. 59. 237-244 (1998)

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      2000 Final Research Report Summary
  • [Publications] Jang,H-K., et al.: "The genetic organization and transcription analysis of the short unique region in the genome of nononcogenic Marek's disease virus serotype 2."Virus Res.. 58. 137-147 (1998)

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      2000 Final Research Report Summary
  • [Publications] Ohashi,K., et al.: "Molecular identification of a recent type of canine distemper virus in Japan by restriction fragment length polymorphism."J.Vet.Med.Sci.. 60. 1209-1212 (1998)

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      2000 Final Research Report Summary
  • [Publications] Izumiya,Y., et al.: "Identification and transcription analysis of the homologues of the Marek 1 s disease virus serotype 2."J.Gen.Virol.. 79. 1997-2001 (1998)

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      2000 Final Research Report Summary
  • [Publications] Ikeda,Y., et al.: "A new quantitative method for detection of feline parvovirus (FPV) and virus neutralizing antibody against FPV using a feline T lymphoid cell line."J.Vet.Med.Sci.. 60. 973-974 (1998)

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      2000 Final Research Report Summary
  • [Publications] Fujita,K., et al.: "In vitro recombination of feline herpesvirus type 1."Arch.Virol.. 143. 25-34 (1998)

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      2000 Final Research Report Summary
  • [Publications] Yamanouchi,K., et al.: "New approaches to the development of virus vaccines for veterinary use."Rev.Sci.Tech.Off.Int.Epiz.. 17. 641-653 (1998)

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      2000 Final Research Report Summary
  • [Publications] Izumiya,Y., et al.: "Identification and sequence analysis of the Marek's disease virus serotype 2 gene homologous to the herpes simplex virus type 1 UL52 protein."J.Vet.Med.Sci.. 61. 683-687 (1999)

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      2000 Final Research Report Summary
  • [Publications] Nakamura,K., et al.: "Molecular cloning and sequence analysis of the phosphoprotein (P) gene of the lapinized rinderpest virus."Virus Gene. 18. 175-178 (1999)

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      2000 Final Research Report Summary
  • [Publications] Kato,K., et al.: "Identification of the Marek's disease virus serotype 2 genes homologous to the glycoprotein B(UL27), the ICP18.5(UL28) and the major DNA-binding protein (UL29) genes of herpes simplex virus type 1."J.Vet.Med.Sci.. 61. 1161-1165 (1999)

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      2000 Final Research Report Summary
  • [Publications] Izumiya, et al.: "Identification and transcriptional analysis of the homologues of the herpes simplex virus type I UL30 to UL40 in the genome of nononcogenic Marek's disease virus serotype"J.Gen.Virol.. 80. 2417-2422 (1999)

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      2000 Final Research Report Summary
  • [Publications] Kurosawa,K., et al.: "Development of restriction fragment-length polymorphism method to differentiate five subtypes of feline immunodeficiency virus."Microbiol.Immunol.. 43. 817-829 (1999)

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      2000 Final Research Report Summary
  • [Publications] Iwatsuki,K., et al.: "Establishment of a persistent mutant of canine distemper virus."Microbe.Infect.. 1. 987-991 (1999)

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      2000 Final Research Report Summary
  • [Publications] Kato,K., et al.: "Identification and sequence analysis of the Marek's disease virus serotype 2 homologous genes of the herpes simplex virus type 1 UL25, UL26 and UL26.5 genes."J.Vet.Med.Sci.. 61. 787-793 (1999)

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      2000 Final Research Report Summary
  • [Publications] Yoshida, et al.: "Epitopes and nuclear localization analysis of canine distemper virus nucleocapsid protein by expression of its deletion mutants."Vet.Microbiol.. 66. 313-320 (1999)

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      2000 Final Research Report Summary
  • [Publications] Hatama,S., et al.: "Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the herpes simplex virus type 1 UL20 and UL21."J.Vet.Med.Sci.. 61. 587-593 (1999)

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      2000 Final Research Report Summary
  • [Publications] Tsushima,Y., et al.: "Gene arrangement and RNA transcription of the Bam HI fragments K and M2 within the nononcogenic Marek's disease virus serotype 2 unique long genome region."Virus Res.. 101-110 (1999)

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      2000 Final Research Report Summary
  • [Publications] Cai,J.-S., et al.: "Identification and structure of the Marek's disease virus serotype 2 glycoprotein M gene : comparison with glycoprotein M genes of Herpesviridae family."J.Vet.Med.Sci.. 61. 503-511 (1999)

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      2000 Final Research Report Summary
  • [Publications] Uema,M., et al.: "Feline immunodeficiency virus subtype C is prevalent in Northern part of Taiwan."J.Vet.Med.Sci.. 61. 197-199 (1999)

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      2000 Final Research Report Summary
  • [Publications] Wakasa,C., et al.: "Sequence analysis of the genes encoding the phophoprotein of recent isolates of canine distemper virus in Japan."J.Vet.Med.Sci.. 62. 97-101 (2000)

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      2000 Final Research Report Summary
  • [Publications] Iwatsuki,K., et al.: "Antigenic differences in the H proteins of canine distemper viruses."Vet.Microbiol.. 71. 281-286 (2000)

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      2000 Final Research Report Summary
  • [Publications] Fujita,K., et al.: "Analysis of Canine interferon-gamma expressed by recombinant Sendai virus."International Veterinary Cytokine and Vaccine Conference, Tsukuba, Japan, March 16th-17th.. (2000)

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      2000 Final Research Report Summary
  • [Publications] Miura,R., et al.: "Purification of recombinant canine granulocyte-macrophage colony stimulating factor produced by Sendai virus expression system."International Veterinary Cytokine and Vaccine Conference, Tsukuba, Japan, March 16th-17th.. (2000)

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      2000 Final Research Report Summary
  • [Publications] Ohashi,K., et al.: "Properties of a new CDV isolated from a raccoon dog (Nyctereutes procyonoides viverrinus) in Japan."Vet.Record.. 148. 148-150 (2001)

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      2000 Final Research Report Summary
  • [Publications] Shiotani,M., et al.: "Molecular properties of the matrixprotein (M) gene of the lapinized rinderpest virus."J.Vet.Med.Sci.. (in press).

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      2000 Final Research Report Summary
  • [Publications] Takeda,M., et al.: "The genome nucleotide sequence of a contemporary wild strain of measles virus and its comparison with the classical Edmonston strain genome."Virology. 256. 340-350 (1999)

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  • [Publications] Okada,H., et al.: "Extensive lymphopenia due to apoptosis of uninfected lymphocytes in acute measles patients."Arch.Virol.. 145. 905-920 (2000)

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  • [Publications] Takeda,M. et al.: "Recovery of pathogenic measles virus from cloned cDNA."J.Virol.. 74. 6643-6647 (2000)

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      2000 Final Research Report Summary
  • [Publications] Ohishi,K., et al.: "Cell-mediated immune responses in cattle vaccinated with a vaccinia virus recombinant expressing the nucleocapsid protein of rinderpest virus."J.Gen.Virol.. 80. 1627-1634 (1999)

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      2000 Final Research Report Summary
  • [Publications] Ohishi,K. et al.: "Lomg-term protective immunity to rinderpest in cattle following a single vaccination with a recombinant vaccinia virus expressing the virus haemagglutinin protein."J.Gen.Virol.. 81. 1439-1446 (2000)

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      2000 Final Research Report Summary
  • [Publications] Ohishi,K., et al.: "Identification of T-helper cell epitopes in the hypervariable region of the nucleocapsid (N) protein of rinderpest virus (RPV) in cattle."Vaccine.. 18. 3077-3081 (2000)

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      2000 Final Research Report Summary
  • [Publications] Yamanouchi,K.: "Potential risk of xenotransplant-associated infections."Transplant.Proc.. 32. 1155-1156 (2000)

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  • [Publications] Onions,D., et al.: "An approach to the control of disease transmission in pig-to-human xenotransplantation."Xenotransplantation. 7. 143-55 (2000)

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      2000 Final Research Report Summary
  • [Publications] Kamata,H., et al.: "Rinderpestvirus (RPV) ISCOM vaccine induces protection in cattle against virulent RPV challenge."Vaccine. (in press).

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      2000 Final Research Report Summary
  • [Publications] Nishino, et al.: "Human immunodeficiency virus type 1 vpr gene product prevents cell proliferation on mouse NIH3T3 cells without G2 arrest of the cell cycle."Biochem.Biophys.Res.Commun.. 232. 550-554 (1997)

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      2000 Final Research Report Summary
  • [Publications] Tani,K., et al.: "Further analysis of the phenotype and distribution of tumor cells in sporadic B-cell and T-cell lymphomas in the lymph node and spleen of cattle."Vet.Immunol.Immunopathol.. 55. 283-290 (1997)

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  • [Publications] Aida,Y., et al.: "The role of tumor-associated antigen in bovine leukemia virus-induced lymphosarcoma."Leukemia. 11. S216-218 (1997)

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      2000 Final Research Report Summary
  • [Publications] Zhuang,W., et al.: "Point mutation of p53 tumor suppressor gene in bovine leukemia virus-induced lymphosarcoma."Leukemia. 11. S344-346 (1997)

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  • [Publications] Koguchi,A., et al.: "Tumor-associated antigen in lymph nodes during the progression of enzootic bovine leukosis."Leukemia. 11. S221-222 (1997)

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  • [Publications] Tajima,S., et al.: "Function and conformation of wild-type p53 protein are influenced by mutations in bovine leukemia virus-induced B-cell lymphosarcoma.."Virology. 243. 235-246 (1998)

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  • [Publications] Inabe,K., et al.: "Transmission and propagation in cell culture of virus produced by cells transfected with an infectious molecular clone of bovine leukemia virus."Virology. 245. 53-64 (1998)

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  • [Publications] Tajima,S., et al.: "Complete bovine leukemia virus (BLV) provirus is conserved in BLV-infected cattle throughout the course of B-cell lymphosarcoma development."J.Virol.. 72. 7569-7576 (1998)

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      2000 Final Research Report Summary
  • [Publications] Fukumori,T., et al.: "The HIV-1 Vpr displays strong anti-apoptotic activity."FEBS letters. 432. 17-20 (1998)

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  • [Publications] Tana, et al.: "Antitumor effect of diphtheria toxin A-chain gene-containing cationic liposomes conjugated with monoclonal antibody directed to tumor-associated antigen of bovine leukemia cells.Z"J.Cancer Res.. 89. 1202-1211 (1998)

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  • [Publications] Inabe,K., et al.: "The YXXL sequences of a transmembrane protein of bovine leukemia virus are required for viral entry and incorporation of viral envelope protein into virion."J.Virol.. 73. 1293-1301 (1999)

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      2000 Final Research Report Summary
  • [Publications] Nagaoka,Y., et al.: "Ovine MHC class II DRB1 alleles associated with resistance or susceptibility to development of bovine leukemia virus-induced ovine lymphoma."Cancer Res.. 59. 975-981 (1999)

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  • [Publications] Kabeya,H., et al.: "Up-regulation of tumor necrosis factor α mRNA is associated with bovine-leukemia virus (BLV) elimination in the early phase of infection."Vet.Immunol.Immunopathol.. 68. 255-265 (1999)

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      2000 Final Research Report Summary
  • [Publications] Nishizawa,M., et al.: "A carboxy-terminally truncated form of the Vpr protein of human immunodeficiency virus type 1 retards cell proliferation independently of G2 arrest of the cell cycle."Virology. 263. 313-322 (1999)

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      2000 Final Research Report Summary
  • [Publications] Nishizawa,M., et al.: "A carboxy-terminally truncated form of the human immunodeficiency virus type 1 Vpr protein induces apoptosis via G1 cell cycle arrest."J.Virol.. 74. 6058-6067 (2000)

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  • [Publications] Kamata,M.and Aida,Y.: "Two putative α-herical domains of human immunodeficiency virus type 1 Vpr mediate nuclear localization by at least two mechanisms."J.Virol.. 74. 7179-7186 (2000)

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      2000 Final Research Report Summary
  • [Publications] Nishizawa,M., et al.: "Induction of apoptosis by the Vpr protein of human immunodeficiency virus type 1 occurs independently of G2 arrest of the cell cycle."Virology. 276. 16-26 (2000)

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      2000 Final Research Report Summary
  • [Publications] Tajima,S and Aida,Y.: "The region between amino acids 245 and 265 of the bovine leukemia virus (BLV) Tax protein restricts transactivation not only via the BLV enhancer but also via other retrovirus enhancers."J.Virol.. 74. 10939-10949 (2000)

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      2000 Final Research Report Summary
  • [Publications] Aida,Y., et al.: "The relationship between polymorphism of the MHC class II DR gene and resistance and susceptibility to bovine leukemia virus-induced lymphoma."Proceeding of the International Veterinary Cytokine and Vaccine Conference (IVCVC),. 159-162 (2000)

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  • [Publications] Takeshita,S. et al.: "Identification of new bovine BoLA-DRB3 alleles by sequence-based typing."Immunogenetics. (in press).

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      「研究成果報告書概要(和文)」より
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      2000 Final Research Report Summary
  • [Publications] Shin, Y.-S., et al.: "Expression of the nucleocapsid protein gene of the canine distemper virus."J.Vet.Med.Sci.. 59(1). 51-53 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Iwatsuki, et al.: "Molecular and phylogenetic analyses of the haemagglutinin proteins of field isolates from dogs naturally infected with canine distemper virus."J.Gen.Virol.. 78. 373-380 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okita, M., et al.: "Histopathological features of canine distemper recently observed in Japan."J.Comp.Pathol.. 116. 40 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Uetsuki, K., et al.: "Protective effects of a novel quinine derivative, E3330, on mouse hepatitis virus (MHV)-induced chronic hepatitis in athymic nude mice."Exp.Anim.. 46(3). 219-223 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shimojima, Y., et al.: "Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the herpes simplex virus type 1 glycoprotein H."J.Vet.Med.Sci.. 59(8). 629-634 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ikeda Y, et al.: "The effects of treatment with chemical agents or infection with feline viruses on protein-binding properties of the feline immunodeficiency virus long terminal repeat."Virus Res. 51(2). 203-12 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nakamura, K., et al.: "Immunization of rabbits against systemic rinderpest virus infection by vaccinia virus expressing the nucleoprotein of rinderpest virus."Comp.Immunol.Microbiol.Infect Dis.. 21. 91-99 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohish, K., et al.: "Construction of recombinant vaccinia virus expressing rinderpest virus nucleocapsid protein and its immunogenicity in mice."J.Vet.Med.Sci.. 60(5). 655-656 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ikeda, et al.: "Protein-binding of the putative AP-1 and ATF sequences in the feline immunodeficiency virus long terminal repeat."J.Gen.Virol.. 79(1). 95-99 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mario, A., et al.: "Nucleotide sequence of the genes encoding glycoproteins I and E of equine herpesvirus type 4."J.Vet.Med.Sci.. 60(2). 219-225 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Iwatsuki, K., et al.: "The nucleotide and predicted amino acid sequence of the fusion protein of recent isolates of canine distemper virus in Japan."J.Vet.Med.Sci.. 60(3). 381-385 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoshida, E., et al.: "Molecular analysis of the nucleocapsid protein of recent isolates of canine distemper virus in Japan."Vet.Microbiiol.. 59. 237-244 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Jang, H-K., et al.: "The genetic organization and transcription analysis of the short unique region in the genome of nononcogenic Marek's disease virus serotype 2."Virus Res.. 58. 137-147 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohashi, K., et al.: "Molecular identification of a recent type of canine distemper virus in Japan by restriction fragment length polymorphism."J.Vet.Med.Sci.. 60(11). 1209-1212 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumiya, Y., et al.: "Identification and transcription analysis of the homologues of the herpes simplex virus type 1 UL41 to UL51 genes in the genome of nononcogenic Marek 1s disease virus serotype 2."J.Gen.Virol.. 79. 1997-2001 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ikeda, Y., et al.: "A new quantitative method for detection of feline parvovirus (FPV) and virus neutralizing antibody against FPV using a feline T lymphoid cell line."J.Vet.Med.Sci.. 60(8). 973-974 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fujita, K., et al.: "In vitro recombination of feline herpesvirus type 1."Arch.Virol.. 143. 25-34 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamanouchi, K., et al.: "New approaches to the development of virus vaccines for veterinary use."Rev.Sci.Tech.Off.Int.Epiz.. 17(3). 641-653 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumiya, Y., et al.: "Identification and sequence analysis of the Marek's disease virus serotype 2 gene homologous to the herpes simplex virus type 1 UL52 protein."J.Vet.Med.Sci.. 61(6). 683-687 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nakamura, K., et al.: "Molecular cloning and sequence analysis of the phosphoprotein (P) gene of the lapinized rinderpest virus."Virus Gene. 18 : 2. 175-178 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kato, K., et al.: "Identification of the Marek's disease virus serotype 2 genes homologous to the glycoprotein B (UL27), the ICP18.5 (UL28) and the major DNA-binding protein (UL29) genes of herpes simplex virus type 1."J.Vet.Med Sci.. 61(10). 1161-1165 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumiya, et al.: "Identification and transcriptional analysis of the homologues of the herpes simplex virus type I UL30 to UL40 in the genome of nononcogenic Marek's disease virus serotype"J.Gen.Virol.. 80. 2417-2422 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kurosawa, K., et al.: "Development of restriction fragment-length polymorphism method to differentiate five subtypes of feline immunodeficiency virus."Microbiol.Immunol.. 43(8). 817-829 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Iwatsuki, K., et al.: "Establishment of a persistent mutant of canine distemper virus."Microbe.Infect.. 1(12). 987-991 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kato, K.et al.: "Identification and sequence analysis of the Marek's disease virus serotype 2 homologous genes of the herpes simplex virus type 1 UL25, UL26 and UL26.5 genes."J.Vet.Med.Sci.. 61(7). 787-793 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoshida, et al.: "Epitopes and nuclear localization analysis of canine distemper virus nucleocapsid protein by expression of its deletion mutants."Vet.Microbiol.. 66. 313-320 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hatama, S., et al.: "Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the herpes simplex virus type 1 UL20 and UL21."J.Vet.Med.Sci.. 61(6). 587-593 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tsushima, Y., et al.: "Gene arrangement and RNA transcription of the Bam HI fragments K and M2 within the nononcogenic Marek's disease virus serotype 2 unique long genome region."Virus Res.. 101-110 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Cai, J.-S., et al.: "Identification and structure of the Marek's disease virus serotype 2 glycoprotein M gene : comparison with glycoprotein M genes of Herpesviridae family."J.Vet.Med.Sci.. 61. 503-511 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Uema, M., et al.: "Feline immunodeficiency virus subtype C is prevalent in Northern part of Taiwan."J.Vet.Med.Sci.. 61(2). 197-199 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Wakasa, C., et al.: "Sequence analysis of the genes encoding the phophoprotein of recent isolates of canine distemper virus in Japan."J.Vet.Med.Sci.. 62(1). 97-101 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Iwatsuki, K., et al.: "Antigenic differences in the H proteins of canine distemper viruses."Vet.Microbiol.. 71. 281-286 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fujita, K., et al.: "Analysis of Canine interferon-gamma expressed by recombinant Sendai virus."International Veterinary Cytokine and Vaccine Conference, Tsukuba, Japan, March 16th-17th. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Miura, R., et al.: "Purification of recombinant canine granulocyte-macrophage colony stimulating factor produced by Sendai virus expression system."International Veterinary Cytokine and Vaccine Conference, Tsukuba, Japan, March 16th-17th. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohashi, K., et al.: "Properties of a new CDV isolated from a raccoon dog (Nyctereutes procyonoides viverrinus) in Japan."Vet.Record. 148. 148-150 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shiotani, M., et al.: "Molecular properties of the matrixprotein (M) gene of the lapinized rinderpest virus."J.Vet.Med.Sci.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takeda, M., et al.: "The genome nucleotide sequence of a contemporary wild strain of measles virus and its comparison with the classical Edmonston strain genome."Virology. 256. 340-350 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Okada, H., et al.: "Extensive lymphopenia due to apoptosis of uninfected lymphocytes in acute measles patients."Arch.Virol.. 145. 905-920 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takeda, M.et al.: "Recovery of pathogenic measles virus from cloned cDNA."J.Virol.. 74(14). 6643-6647 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohishi, K., et al.: "Cell-mediated immune responses in cattle"232. 550-554 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tani, K., et al.: "Further analysis of the phenotype and distribution of tumor cells in sporadic B-cell and T-cell lymphomas in the lymph node and spleen of cattle."Vet.Immunol.Immunopathol.. 55. 283-290 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Aida, Y.et al.: "The role of tumor-associated antigen in bovine leukemia virus-induced lymphosarcoma."Leukemia. 11. S216-218 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Zhuang, W., et al.: "Point mutation of p53 tumor suppressor gene in bovine leukemia virus-induced lymphosarcoma."Leukemia. 11. S344-346 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Koguchi, A., et al.: "Tumor-associated antigen in lymph nodes during the progression of enzootic bovine leukosis."Leukemia. 11. S221-222 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tajima, S., et al: "Function and conformation of wild-type p53 protein are influenced by mutations in bovine leukemia virus-induced B-cell lymphosarcoma."Virology. 243. 235-246 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Inabe, K., et al.: "Transmission and propagation in cell culture of virus produced by cells transfected with an infectious molecular clone of bovine leukemia virus."Virology. 245. 53-64 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tajima, S., et al.: "Complete bovine leukemia virus (BLV) provirus is conserved in BLV-infected cattle throughout the course of B-cell lymphosarcoma development."J.Virol.. 72. 7569-7576 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukumori, T., et al.: "The HIV-1 Vpr displays strong anti-apoptotic activity."FEBS letters. 432. 17-20 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tana, et al.: "Antitumor effect of diphtheria toxin A-chain gene-containing cationic liposomes conjugated with monoclonal antibody directed to tumorassociated antigen of bovine leukemia cells."Jpn.J.Cancer Res.. 89. 1202-1211 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Inabe, K., et al.: "The YXXL sequences of a transmembrane protein of bovine leukemia virus are required for viral entry and incorporation of viral envelope protein into virion."J.Virol.. 73. 1293-1301 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nagaoka, Y., et al.: "Ovine MHC class II DRB1 alleles associated with resistance or susceptibility to development of bovine leukemia virus-induced ovine lymphoma."Cancer Res.. 59. 975-981 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kabeya, H., et al.: "Up-regulation of tumor necrosis factor α mRNA is associated with bovine-leukemia virus (BLV) elimination in the early phase of infection."Vet.Immunol.Immunopathol.. 68. 255-265 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nishizawa, M., et al.: "A carboxy-terminally truncated form of the Vpr protein of human immunodeficiency virus type 1 retards cell proliferation independently of G2 arrest of the cell cycle."Virology. 263. 313-322 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nishizawa, M., et al.: "A carboxy-terminally truncated form of the human immunodeficiency virus type 1 Vpr protein induces apoptosis via G1 cell cycle arrest."J.Virol.. 74. 6058-6067 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kamata, M.and Aida, Y.: "Two putative α-herical domains of human immunodeficiency virus type 1 Vpr mediate nuclear localization by at least two mechanisms."J.Virol.. 74. 7179-7186 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nishizawa, M., et al.: "Induction of apoptosis by the Vpr protein of human immunodeficiency virus type 1 occurs independently of G2 arrest of the cell cycle."Virology. 276. 16-26 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tajima, S and Aida, Y.: "The region between amino acids 245 and 265 of the bovine leukemia virus (BLV) Tax protein restricts transactivation not only vial the BLV enhancer but also via other retrovirus enhancers."J.Virol.. 74. 10939-10949 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Aida, Y.et al.: "The relationship between polymorphism of the MHC class II DR gene and resistance and susceptibility to bovine leukemia virus-induced lymphoma."International workshop on the potential application of recombinant cytokines and DNA vaccines for the control of infectious disease of domestic animals, Proceeding of the International Veterinary Cytokine and Vaccine Conference (IVCVC). 159-162 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takeshita, S et al.: "Identification of new bovine BoLA-DRB3 alleles by sequencebased typing."Immunogenetics. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Iwatsuki,K., et al.,: "Antigenic differences in the H proteins of canine distemper viruses."Vet.Microbiol.. 71. 281-286 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohashi,K., et al.,: "Antigenic and molecular cloning of a new CDV isolated from a raccoon dog (Nyctereutes procyonoides viverrinus) in Japan."Vet.Record. 148. 148-150 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Wakasa,C., et al.,: "Sequence analysis of the genes encoding the phosphoprotein of recent isolates of canine distemper virus in Japan."J.Vet.Med.Sci.. 62. 97-101 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Okada,H. et al.,: "Extensive lymphopenia due to apoptosis of uninfected lymphocytes in acute measles patients."Arch.Virol.. 145. 905-920 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takeda,M., et al.,: "Recovery of pathogenic measles virus from cloned cDNA."J.Virol.. 74(14). 6643-6647 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohishi,K., et al.,: "Lomg-term protective immunity to rinderpest in cattle following a single vaccination with a recombinant vaccinia virus expressing the virus haemagglutinin protein."J.Gen.Virol.. 81. 1439-1446 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohishi,K., et al.,: "Identification of T-helper cell epitopes in the hypervariable region of the nucleocapsid (N) protein of rinderpest virus (RPV) in cattle."Vaccine,. 18. 3077-3081 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamanouchi,K.: "Potential risk of xenotransplant-associated infections."Transplant.Proc.. 32. 1155-1156 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Onoions,D., et al.,: "An approach to the control of disease transmission in pig-to-human xenotransplantation."Xenotransplantation,. 7(2). 143-155 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kamata,H., et al.,: "Rinderpestvirus (RPV) ISCOM vaccine induces protection in cattle against virulent RPV challenge. "Vaccine,. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Nishizawa, et al.,: "A carboxy-terminally truncated form of the human immunodeficiency viurs type 1 Vpr protein induces apoptosis via G1 cell cycle arrest. "J.Virol.,. 74. 6058-6067 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kamata,M.and Aida,Y.: "Two putative α-herical domains of human immunodeficiency virus type 1 Vpr mediate nuclear localization by at least two mechanisms."J.Virol.,. 74. 7179-7186 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nishizawa,M., et al.,: "Induction of apoptosis by the Vpr protein of human immunodeficiency virus type 1 occurs independently of G2 arrest of the cell cycle."Virology,. 276. 16-26 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tajima,S and Aida,Y.: "The region between amino acids 245 and 265 of the bovine leukemia virus (BLV) Tax protein restricts transactivation not only via the BLV enhancer but also via other retrovirus enhancers."J.Virol.. 74. 10939-10949 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takeshita,S., et al.,: "Identification of new bovine BoLA-DRB3 alleles by sequence-based typing."Immunogenetics,. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] 小船富美夫 ら: "麻疹ワクチン既接種者の麻疹罹患とわが国の麻疹対策-沖縄県八重山地区での麻疹流行"臨床とウイルス. 28. 10-14 (2000)

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  • [Publications] 野田雅博 ら: "麻疹ワクチン接種後の抗体持続および野外ウイルス株の変異が予防接種による獲得抗体に及ぼす影響"臨床とウイルス. 28. 23-30 (2000)

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  • [Publications] 小船富美夫 ら: "麻疹ウイルス(MV)中和試験の改良と標準化"臨床とウイルス. 28. 31-34 (2000)

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  • [Publications] 甲斐知恵子: "野生動物でのエマージングウイルス"SUT。東京理科大学出版会. 5 (2000)

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  • [Publications] 甲斐知恵子: "諸外国での野生動物におけるウイルス感染症の流行"JVMm. 4 (2000)

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      2000 Annual Research Report
  • [Publications] 大橋謙司郎,甲斐知恵子: "日本の野生動物におけるモービリウイルス感染症"JVMm. 5 (2000)

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      2000 Annual Research Report
  • [Publications] 甲斐知恵子: "ジステンパー"InfoVets,. 4 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yoshida, E. et al.: "Epitopes and nuclear localization analysis of canine distemper virus nucleocapsid protein by expression of its deletion mutants"Vet. Microbiol.. 66. 313-320 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Iwatsuki, K. et al.: "Establishment of a persistent mutant of canine distemper virus"Microbe. Infect. 1(12). 987-991 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Iwatsuki, K. et al.: "Antigenic differences in the H proteins of canine distemper viruses"Vet. Microbiol.. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagaoka, Y, et al.: "Ovine MHC class II DRB1 alleles associated with resistance or susceptibility to development of bovine leukemia virus-induced ovine lymphoma"Cancer Res.. 59(4). 975-981 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Inabe, K. et al.: "The YXXL sequences of a transmembrane protein of bovine leukemia virus are required for viral entry and incorporation of viral envelope protein into virions"J Virol.. 73(2). 293-301 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yoshida,E.,et al.: "Epitopes and nuclear localization analysis of canine distemper virus nucleocapsid protein by expression of its deletion mutants" Vet.Microbiol.(In press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakamura,K.,et al.: "Molecular cloning and sequence analysis of the phosphoprotein (P) gene of the lapinized rinderpest virus" Virus Gene. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamanouchi,K.,et al.: "New approaches to the development of virus vaccines for veterinary use" Rev.Sci.Tech.Off.Int.Epiz.17(3). 641-653 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshida,E.,et al.: "Molecular analysis of the nucleocapsid protein of recent isolates of canine distemper virus in Japan" Vet.Microbiiol.59. 237-244 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tajima S.,et al.: "Complete bovine leukemia virus (BLV) provirus is conserved in BLV-infected cattle throughout the course of B-cell lymphosarcoma" J.Virology. 72. 7569-7576 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Inabe K.,et al.: "The YXXL sequences of bovine leukemia virus transmembrane protein are required for maintenance of viral penetration and incorporation of viral envelope protein into virion" J.Virology. 73. 1293-1301 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 甲斐知恵子: "ウマからヒトに感染するモービリウイルス感染症" 遺伝, 5 (1999)

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  • [Publications] 間陽子: "疾患感受性を規定するウシMHCクラスII分子の構造と機能" 動物遺伝研究会誌, 12 (1998)

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  • [Publications] Aida,Y., et al.: "The role of tumor-associated antigen in bovine leukemia virus-induced lymphosarcoma." Leukemia. 11. 216-218 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Koguchi,A., et al.: "Tumor-associated antigen in lymph nodes during the progression of enzootic bovine leukosis." Leukemia. 11. 221-222 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Zhuang,W., et al.: "Point mutation of p53 tumor suppressor gene in bovine leukemia virus-induced lymphosarcoma." Leukemia. 11. 344-346 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakamura,K., et al.: "Immunizing effect of vaccinia virus expressing the nucleoprotein of rinderpest virus on systemic rinderpest virus infection in rabbits." Comp.Immunol.Microbiol.Infct.Dis.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohishi,K., et al.: "Immunogenicity of recombinant vaccinia virus(rVV)expressing rinderpest virus nucleocapsid protein in mice." J.Vet.Med.Sci.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamanouchi,K., et al: "New approaches to the development of virus vaccines for veterinary use." Rev.sci.tech.Off.int.Epiz.(in press).

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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