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Development of methods for molecular biological analysis of stress responses

Research Project

Project/Area Number 09557006
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

HORI Tetsuro  Kyushu University, Dept. of Physiology, Professor, 大学院・医学系研究科, 教授 (00022814)

Co-Investigator(Kenkyū-buntansha) TAKE Sachiko  Kyushu University, Dept. of Physiology, Assistant Professor, 大学院・医学系研究科, 助手 (80253425)
TAKAKI Atsushi  Kyushu University, Dept. of Physiology, Assistant Professor, 大学院・医学系研究科, 助手 (30243934)
KATAFUCHI Toshihiko  Kyushu University, Dept. of Physiology, Assistant Professor, 大学院・医学系研究科, 講師 (80177401)
岡 孝和  九州大学, 医学部, 助手 (60291514)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 1999: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1998: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1997: ¥6,300,000 (Direct Cost: ¥6,300,000)
KeywordsFos protein / antisense oligo DNA / quantitative RT-PCR / immobilization / heat / cold exposure / medical preoptic area / IFN-α / IL-1β / 暑熱暴露 / 視床下部 / 老化 / リアルタイムRT-PCR / 体温調節 / 定量化RT-PCR / ストレス / FOS蛋白 / 早期遺伝子
Research Abstract

We have developed the methods for to analyze the expression of brain cytokines and an immediate eary gene, c-fos, during the stress response to various environmental stimuli using molecular biological techniques. We also examined the effects of microinjection of antisense oligo DNA for c-fos mRNA into the hypothalamus on the responses to the stressors. Our findings are as follows ;
(1) Cytokines including IL-1β and IFNα were expressed in the brain in response to not only inflammatory stresses but also non-inflammatory stresses such as immobilization (IMB) and heat (33℃) or cold (4℃) exposure.
(2) Quantitative analyses of the mRNA for brain cytokines and neuropeptide were successively performed by competitive RT-PCR using mimic cDNA and real-time capillary RT-PCR methods.
(3) We observed an expression of Fos protein in the medial preoptic area (MPO), paraventricular nucleus (PVN), and ventromedial nucleus (VMH) in the hypothalamus after IMB and heat or cold exposure for 2 hours.
(4) Express … More ion of c-fos mRNA equally increased in the respective hypothalamus nuclei in rats by heat exposure when measured by real-time papillary RT-PCR methods. However, cold exposure induced marked increases in the amount of c-fos mRNA in the MPO, lateral hypothalamus (LHA), and VMH.
(5) Heat exposure produced a decrease in IL-1β and an increase in IFN-αmRNA contents, while mRNAs for IL-6 and TNF-α were not affected.
(6) For protein expressed in rat MPO during heat or cold exposure works to elevate body temperature since blockage of Fos expression by antisense oligo DNA for c-fos mRNA results in the decrease in body temperature during both heat and cold exposure.
(7) The suppression of Fos protein induced by antisense oligo DNA was accompanied by the increase in the amount of c-fos mRNA in the MPO, suggesting an autoinhibitory action of Fos protein on the expression of c-fos gene. This also suggests that the suppression of Fos protein by antisense oligo DNA results from an inhibition of the translation of c-fos mRNA. Furthermore, since the expression of IFN-αmRNA by heat exposure was suppressed by antisense oligo DNA, it is suggested that one of the target genes of Fos protein is IFN-α gene. Less

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (168 results)

All Other

All Publications (168 results)

  • [Publications] 堀哲郎: "ストレスとNeuroimmunomodulation"日本集中治療医学会雑誌. 4. 3-9 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "自律神経系による免疫系制御"Clinical Neuroscience. 15. 394-396 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "発熱の科学"救急医学. 21. 1000-1015 (1997)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "怒りはどこから湧き、どのように発散されるか"COMMUNICATION. 68. 12-15 (1997)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 片渕俊彦: "精神神経系とNK細胞.特集II-NK細胞の新しい展開"炎症と免疫. 5・1. 51-60 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "サイトカインと脳・免疫連関"Clinical Neuroscience. 16. 401-405 (1998)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "脳・免疫系連関における伝達物質"Clinical Neuroscience. 16. 93-97 (1998)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "脳・免疫系連関に関する最近の進歩"老年精神医学雑誌. 9・11. 1381-1392 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "精神系内分泌系と免疫系との相互作用"免疫・Immunology Frontier. 8・6. 333-341 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "神経・内分泌・免疫連関"アレルギーの領域. 6・1. 52-61 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 栗生修司: "ここまでわかった食欲不振の病態生理"Journal of Integrated Medicine(JIM). 8. 638-641 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 栗生修司: "情動の脳科学"心療内科. 2. 429-434 (1998)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 片渕俊彦: "発熱とサイトカイン"Clinical Neuroscience. 16・4. 73-75 (1998)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 片渕俊彦: "ストレスと免疫系"感染 炎症 免疫. 28(2). 106-115 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 栗生修司: "食欲のしくみ"婦人之友. 92. 104-109 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 栗生修司: "摂食行動の基礎"心身医学. 39. 99-109 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 李学良: "OLETFラットの学習障害と[Ala]16-aFGF(1-29)による改善"OLETFラット研究会記録集. 最終巻. 101-104 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "神経・内分泌・免疫連関"アレルギー・免疫. 6. 52-61 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "脳・免疫系連関に関する最近の進歩(討論)"中枢神経懇話会記録. 9. 1-18 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "情動と免疫"Clinical Neuroscience. 48(7). 772-775 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "サイトカインと神経伝達物質"日本薬理学会誌. 115. 209-218 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "無意識の世界が感情をつくる"えれきてる. 75(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ota, K: "The AV3V neurous which send axons to hypothalamic nuclei respond to the system injection ofIL-1 b."Am. J. Physiol.. 272. R532-R540 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li, A. J.: "Interleukin-6 inhibits long-term potentiation in rat hippocampal slices"Brain Res.. 748. 30-38 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka, T.: "Biphasic alteration in the trigeminal nociceptive neuronal responses after intracerebroventricular injection of prostaglandin E2 in rats."Brain Res.. 749. 354-357 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katafuchi, T.: "Differential effects of tumor necrosis factor-a and -b on the rat ventromedial hypothalamic neurons in vitro"Am. J. Physiol.. 272. R1966-R1971 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosoi, M.: "Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca in rats."Pain. 71. 303-311 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka, K.: "Prostaglandin E2 may induce hyperthermia through EP1-receptors in the anterior wall of the third ventricle and neighboring preoptic regions."Brain Res.. 767. 92-99 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T.: "Cell biology and the functions of thermosensitive neurons in the brain."Prog. Brain Res.. 115. 9-23 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shiramine, K.: "Lateral hypothalamic injection of GABAA antagonist induces gastric vagus-mediated"Am. J. Physiol.. 273. R1492-R1500 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka, T.: "Biphasic modulation in the trigeminal nociceptive neuronal responses by the intracerebroventricular proostaglandin E2 may be mediated through different EP receptors subtype in rats"Brain Res.. 771. 278-284 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katafuchi, T.: "Sequential relationship between actions of CRF and PGE2 in the brain on splenic sympathetic nerve activity in rats."J. Auton. Nerv. Syst.. 67. 200-206 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T.: "Pain modulatorry actions of cytokines and PGE2 in the brain."Ann. New York Acad. Sci.. 840. 319-334 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li, A-J.: "A single pre-training glucose injection induces memory facilitation in ordents perform various tasks: contribution of acidic firbroblast growth factor."Neuroscience. 85. 785-794 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T.: Neuroimmunomodulation. 5. 172-177 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T: "Cell biology and the functions of thermosensitive neurons in the brain. In Brain Function in Hot Environment: Basic and Clinical Perspectives."Progress in Brain Research. 115. 9-23 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T: "Pain modulatory actions of cytokines and PGE2 in the brain."Ann. New York Acad. Sci.. 840. 269-281 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamikawa, H.: "IL-1 b increases norepinephrine level in rat frontal cortex: involvement of prostanoids, NO and glutamate."Am. J. Physiol.. 275. 803-810 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka, K.: "PGE2 receptor subtype EP1 antagonist may inhibit central interleukin-1 b -induced fever in rats."Am. J. Physiol. 275. 1762-1765 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamikawa, H.: "Hyperalgesic responses to noxious stimulation in genetically polydipsic mice."Brain Research. 846. 101-104 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li, A-J: "Protective effect of acidic fibroblast growth factor against ischemia-induced learning and memory deficits in two tasks in gerbils."Physio. & Behav.. 66(4). 577-583 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Prostaglandin E2 has antiociceptive effect through EPI receptor in the ventromedial hypothalamus in rats.: Pain. 82. 221-227 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Araishi, K: "Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophy in b- sarcoglycan-deficient mice"Human Molecular Genetics. 8. 1589-1598 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamikawa, H: "Hyperalgesic response to noxious stimulation in genetically polydipsic mice."Brain Res.. 846. 171-176 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T: "Evidence for th einvolvement of AV3V in the circulating IL-B-to-brain communication."Journal of Thermal Biology. 25. 29-33 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T.: "Hypothalamic mechanisms of pain modulatory actions of cytokines and prostaglandin E2."Ann. N.Y. Acad. Sci.. (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "最新内科学大系プログレスシリーズ2「内分泌・代謝疾患」"中山書店. 419 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "脳機能の解明ー21世紀に向けて"九州大学出版会. 615 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 栗生修司: "摂食障害"日本評論社. 156 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 片渕俊彦: "内科学進歩のトピックス"九州大学出版会. 394 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 片渕俊彦: "インターフェロン-その研究の歩みと臨床応用への可能性-"ライフサイエンス. 211 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "麻酔科医のための生理学"真興交易医書出. 388 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 片渕俊彦: "免疫学からみた神経系と神経疾患"日本医学館. 374 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀 哲郎: "サイトカインと疾患"羊土社(印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka, T.: "Brain cytokines and pain"Birkhaeuser Publishing Ltd. 225 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takaki, A.: "Brain and Biodefence"Japan Scientific Societies Press. 248 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katafuchi, T.: "Brain and Biodefence"Japan Scientific Societies Press. 248 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li, A,-J.: "Brain and Biodefence"Japan Scientific Societies Press. 248 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takaki, A: "Control Mechanisms of Stress and Emotion: Neuroendocrine-Based Studies"Elsevier Science B.V. 359 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katafuchi, T.: "Thermotherapy: Principles and Practice-Applications in Neoplasia, Inflammation, and Pain-"Spinger-Velag Tokyo Inc. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T.: "Psychoneuroimmunology"Academic Press Inc. (印刷中). (200)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T.: "Pain and Neuroimmune Interactions"Kluwer Academic/Plenum Press . (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Aou, S.: "Thermotherapy: Principle and Practice--Application and neoplasia, Inflammation, and Pain."Springer- Verlag . (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, Y: "Thermotherapy: Principle and Practice--Application and neoplasia, Inflammation, and Pain."Springer- Verlag . (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ota, K., Takaki, A., Katafuchi, T. & Hori, T.: "The AV3V neurons which send axons to hypothalamic nuclei response to the systemic injection of IL-1β"Am. J. Physiol.. 272. R532-R540 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li, A. J., Katafuchi, T., Oda, S., Hori, T. & Oomura, Y.: "Interleukin-6 inhibits long-term potentiation in rat hippocampal slices"Brain Res.. 748. 30-38 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka, T., Hosoi, M., Oka, K. & Hori, T.: "Biphasic alteration in the trigeminal nociceptive neuronal response after intracerebroventricular injection of prostaglandin E2 in rats"Brain Res.. 749. 354-357 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katfuchi, T., Motomura, K., Baba, S., Ota, K. & Hori, T.: "Differential effects of tumor necrosis factor -α and -β on rat ventromecial hypothalamic neurons in vivo"Am. J. Physiol.. 272. R1966-R1979 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosoi, M., Oka, T., & Hori., T.: "Prostaglandin E receptor EP3 subtype is minvolved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca in rats"Pain. 71. 303-311 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka., K., Oka, T., $ Hori, T.: "Prostaglandin E2 may induce hyperthermia through EP1-receptors in the anterior wall of the third ventricle and neighboring preoptic regions"Brain Res.. 767. 92-99 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shiramine, K., Aou, S., & Hori, T.: "Lateral hypothalamic injection of GABAA antagonist induces gastric vagus-mediated hypocalcemia in the rat"Am. J. Physiol.. 273. 3R1492-R1500 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka, T., Hori, T., Hosoi, M., Oka, K. & Kubo, C.: "Biphasic modulation in the trigeminal nociceptive neuronal responses by the intracerebroventricular prostaglandin E2 may be mediated through different EP receptors subtype in rats"Brain Res.. 771. 278-284 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katafuchi, T., Ichijyo, T., & Hori, T.: "Sequential relationship between actions of CRF and PGE2 in the brain on splenic sympathetic nerve activity in rats"J. Autonom. Nerv. System. 67. 200-206 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T., Oka, T., Hosoi, M. & Aou, S.: "Pain modulatory actions of cytokines and PGE2 in the brain"Ann. New York Acad. Sci.. 840. 269-281 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li, A. -J., Oomura, Y., Sasaki, K., Suzuki, K., Tooyama, I., Hanai, K., Kimura, H. and Hori, T.: "A single pre-training injection induces memory facilitation in rodents performing various tasks : contribution of acidic fibroblast growth factor"Neuroscience. 85. 785-794 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T., Katafuchi, T., Take, S. & Shimizu, N.: "Neuroimmunomodulatory actions of hypothalamus interferon-α"Neuroimmunomodulation. 5. 172-177 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka, K., Oka, T. & Hori, T.: "PGE2 receptor subtype EP1 antagonist may inhibit central interleukin-1β induced fever in rats"Am. J. Physiol.. 275. R1762-R1765 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T. & Katafuchi, T.: "Cell biology and the Functions of thermosensitive neurons in the brain"In : Brain Function in Hot Environment : Basic and Clinical Perspectives. (Eds, H. S. Sharma and J. Westman) Progress in Brain Research, Elsevier, Amsterdam. vol. 115. 9-23 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katafuchi, T., Kono, T., Take, S. & Hori, T.: "Hypothalamus modulation of delayed-type hypersensitivity and splenic natural killer cell activity"In : Brain and Biodefense (Eds, Oomura, Y. & Hori, T.) Japan Scientific Societies, Press, Tokyo/Karger, Basel. 3-11 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takaki, A., Shioda, S., Ito, K., Maeda, M., Kanemitsu, Y., Yagi, S., Arimura, A. & Hori, T.: "Non-inflammatory stress and brain-gut-liver-immune axis"In : Brain and Biodefense (Eds, Oomura, Y. & Hori, T.) Japan Scientific Societies, Press, Tokyo/Karger, Basel. 155-160 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li, A. -J., Oomura, Y., Sasaki, K., Hori, T., Tooyama, I., Nomura, Y., Hanai, K., Kimura, H., Yanaihara, N., Yoshii, H., Yamazaki, Y., Take, S. & Hori, T.: "Actions of a FGF in senescence-accelerated mice : protective effects against deficits of learning and memory, and effects on immunological functions"In : Brain and Biodefense (Eds, Oomura, Y. & Hori, T.) Japan Scientific Societies, Press, Tokyo/Karger, Basel. 51-61 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oka, T, & Hori, T.: "Brain cytokines and pain"In : Cytokines and Pains (eds. Watkins, L. R. & Maier, S. F.) Birkhaeuser Publishing Ltd. Basel, Switzerland. 183-203 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li, A. -J., Oomura, Y., Sasaki,K., Suzuki, K. & Hori, T.: "Protective effect of acidic fibroblast growth factor against ischemia-induced learning and memory deficits in two tasks in gerbils"Physiol. & Behav.. 66(4). 577-583 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hosoi, M., Oka, T., Abe, M., Hori, T., Yamamoto, H., Mine, K. & Kubo, C.: "Prostagladin E2 has antinociceptive effect through EP1 receptor in the ventromedial hypothalamus in rats"Pain. 82. 221-227 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamikawa, H., Katafuchi, T., Hosoi, M., Yamamoto, T. & Hori, T.: "Hyperalgestic response to noxious stimulation in genetically polydipsic mice"Brain Res.. 846. 171-176 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Araishi, K., Sasaoka, T., Imamura, M., Noguchi, S., Hama, H., Wakabayashi, E., Yoshida, M., Hori, T. & Ozawa, E.: "Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophyin β-sarcoglycan-deficient mice"Human Molecular Genetics. 8. 1589-1598 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takaki, A., Hori, T., Yagi, S., Oka, K., Kanemitsu, Y., Sudo, N., Shioda, S. & Arimura, A.: "Plasma IL-6 and its pyrogenecity during noniflammatory stress"IN : Control Mechanisms of Stress and Emotion : Neuroendocrine-Based Studies. (Eds. Yamashita, H., Funder, J. W. Verbalis, J. G. Ueta, Y. & Endo, Y.) Elsevier Science B. V., Amsterdam, The Netherlands. 173-177 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T., Katafuchi, T., Oka, K., Matsuda, T., Oka, T. & Oka, K.: "Evidence for the involvement of AV3V in the circulating IL-1β-to-brain communication"J. Thermal. Biol.. 25. 29-33 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T., Oka, T., Hosoi, M., Abe, M. & Oka, K.: "Hypothalamic mechanisms of pain modulatory actions of cytokines and prostaglandin E2"Ann. N. Y. Acad. Sci.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T., Oka, T., Hosoi, M., Abe, M. & Oka, K.: "Biphasic modulation of pain by hypothalamus cytokines"In Pain and Neurimmune Interactions (Eds. Saade, N. E.) Kluwer Academic/Plenum Press. 171-190 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori, T., Takafuchi, T. & Oka, T.: "Central cytokines : effects on periphreral immunity, inflammation and nociception"In : Psychoneuroimmunology, Third Edition, (Eds. Ader. R., Felten, D. L. & Cohen, N.) Academic Press. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamikawa, H., Hori, T., Nakane, H., Aou, S. & Tachiro, N.: "IL-1β increases norepinephrine level in rat frontal cortex : involvement of prostanoids, NO and glutamate"Am. J. Physiol.. 275. R803-R810 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 片渕俊彦: "ストレスと免疫系"感染炎症免疫. 28(2). 106-115 (1998)

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      1999 Annual Research Report
  • [Publications] Kamikawa,H.: "Hyperalgesic response to noxious stimulation in genetically polydipsic mice."Brain Research. 846. 171-176 (1999)

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      1999 Annual Research Report
  • [Publications] 李学良: "OLETFラットの学習障害と[AIa]16-aFGF(1-29)による改善"OLETFラット研究会記録集. 最終巻. 101-104 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Li,A-J: "Protective effect of acidic fibroblast growth factor against ischemia-induced learning and memory deficits in two tasks in gerdils."Physiol.& Behav.. 66(4). 577-583 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hosoi,M: "Prostaglandin E2 has antinociceptive effect through EP1 receptor in ventromedial hypothalamus in rats."Pain. 82. 221-227 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Araishi,K: "Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophy in β-sarcoglycan-deficient mice."Human Molecular Genetics. 8. 1589-1598 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kamikawa,H: "Hyperalgesic response to noxious stimulation in genetically polydipsic mice"Brain Res.. 846. 171-176 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 堀 哲郎: "神経・内分泌・免疫連関"アレルギー・免疫. 6. 52-61 (1999)

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      1999 Annual Research Report
  • [Publications] 堀 哲郎: "脳・免疫系連関に関する最近の進歩(討論)"中枢神経懇話会記録. 9. 1-18 (1999)

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  • [Publications] 堀 哲郎: "情動と免疫"Clinical Neuroscience. 48(7). 772-775 (1999)

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      1999 Annual Research Report
  • [Publications] Hori,T.: "Evidence for th einvolvement of AV3V in the circulation IL-β-to-brain communication."Journal of Thermal Biology. 25. 29-33 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hori,T.: "Hypothalamic mechanisms of pain modulatory actions of cytokines and prostaglandin E2."Ann.N.Y.Acad.Sci.. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 堀 哲郎: "サイトカインと神経伝達物質"日本薬理学会誌. 115. 209-218 (2000)

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      1999 Annual Research Report
  • [Publications] 堀 哲郎: "無意識の世界が感情をつくる"ゑれきてる. 75(印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 片渕俊彦: "インターフェロン -その研究の歩みと臨床応用への可能性"ライフサイエンス. 211 (1998)

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  • [Publications] 片渕俊彦: "免疫学から見た神経系と神経疾患"日本医学館. 374 (1999)

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      1999 Annual Research Report
  • [Publications] 堀 哲郎: "麻酔生理学"真興交易医書出版. 388 (1999)

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      1999 Annual Research Report
  • [Publications] Takaki,A: "Control Mechanisms of Stress and Emotion:NeuroendocrineーBased Studies"Elsevier Science B.V. 359 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 堀 哲郎: "サイトカインと疾患"羊土社(印刷中). (2000)

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      1999 Annual Research Report
  • [Publications] Katafuchi,T.: "Thermotherapy:Principles and PracticeーApplications in Neoplasia,Inflammation,and pain-"SpringerーVerlag Tokyo Inc.(印刷中). (2000)

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      1999 Annual Research Report
  • [Publications] Hori,T.: "Psychoneuroimmunology"Academic Press Inc.(印刷中). (2000)

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      1999 Annual Research Report
  • [Publications] Hori,T.: "Pain and Neuroimmune Interactions"Kluwer Academic/Plenum Press(印刷中). (2000)

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      1999 Annual Research Report
  • [Publications] Aon,S.: "Thermotherapy:Principle and PracticeーApplication and neoplasia,Inflamーmation,and Pain."SpringerーVerlag(印刷中). (2000)

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      1999 Annual Research Report
  • [Publications] Hori,T.: "Thermotherapy:Principle and PracticeーApplication and neoplasia,Inflamーmation,and Pain."SpringerーVerlag(印刷中). (2000)

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      1999 Annual Research Report
  • [Publications] Hori.T: "Cell biology and the functions of thermosensitive neurons in the brain.in Brain Function in Hot Environment:Basic and Clinical Perspectives." Progress in Brain Research. 115. 9-23 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hori.T: "Pain modulatory actions of cytokines and PGE2 in the brain." Ann New York Acad.Sci. 840. 269-281 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Li,A-J.: "A single pre-training gulucose injection memory facilitation in rodentsperforming various tasks:contribution of acidic fibroblast growth factor." Neuroscience. 85. 785-794 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hori,T.: "Neuroimmunomodulatory actions ofhypothalamic interferon-α." Neuroimmunomodulation. 5. 172-177 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kamikawa,H.: "IL-1 increases norepinephrine level in rat frontal cortex:involvement of prostanoids,NO and glutamate." Am.J.Physiol.275. 803-810 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Oka,K.: "PGE2 receptor subtype EP1 antagonist may inhibit central interleukin-1β-induced fever in rats." Am.J.Physiol.275. 1762-1765 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 堀 哲郎: "サイトカインと脳・免疫系連関" Clinical Neuroscience. 16. 401-405 (1998)

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      1998 Annual Research Report
  • [Publications] 堀 哲郎: "脳・免疫系連関と伝達物質" Clinical Neuroscience. 16. 93-97 (1998)

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      1998 Annual Research Report
  • [Publications] 堀 哲郎: "脳・免疫系連関に関する最近の進歩" 老年精神医学雑誌. 9・11. 1381-1392 (1998)

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  • [Publications] 堀 哲郎: "神経系内分泌系と免疫系との相互作用" 免疫・Immunology Frontier. 8・6. 333-341 (1998)

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  • [Publications] 堀 哲郎: "神経・内分泌・免疫連関" アレルギーの領域. 6・1. 52-61 (1998)

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  • [Publications] 粟生修司: "ここまでわかった食欲不振の病態生理." Jourmal of Integrated Medicine(JLM). 8. 638-641 (1998)

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  • [Publications] 粟生修司: "情同の脳科学." 心療内科. 2. 429-434 (1998)

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      1998 Annual Research Report
  • [Publications] 粟生修司: "摂食行動の基礎." 心身医学. 39. 99-109 (1999)

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  • [Publications] 片渕俊彦: "精神神経系とNK細胞.特集-NK細胞の新しい展開." 炎症と免疫. 5・1. 51-60 (1997)

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  • [Publications] 片渕俊彦: "発熱とサイトカイン." Clinical Neuroscience. 16・4. 73-75 (1998)

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  • [Publications] 片渕俊彦: "ストレスと免疫." 感染 炎症 免疫. 28-2. 106-115 (1998)

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      1998 Annual Research Report
  • [Publications] 粟生修司: "食欲のしくみ." 婦人之友. 92. 104-109 (1998)

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  • [Publications] Takaki,A.: "Brain and Biodefence" Japan Scientific Societies Press, 248 (1998)

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  • [Publications] Katafuchi,T.: "Brain and Biodefence" Japan Scientific Societies Press, 248 (1998)

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  • [Publications] Li,A,-J.: "Brain and Biodefence" Japan Scientific Societies Press, 248 (1998)

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      1998 Annual Research Report
  • [Publications] Oka,T.: "Cytokines and Pain" Birkhaeuser Publishing Ltd,Basel, 225 (1998)

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      1998 Annual Research Report
  • [Publications] Hori,T.: "Psychoneuroimmunology,Third Edition" Academic Press(in press), (1999)

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      1998 Annual Research Report
  • [Publications] 堀 哲郎: "脳機能の解明-21世紀に向けて" 九州大学出版会, 615 (1998)

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  • [Publications] 粟生修司: "摂食障害" 日本評論社, 156 (1998)

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  • [Publications] 片渕俊彦: "内科学進歩のトピックス" 九州大学出版会, 394 (1998)

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  • [Publications] 片渕俊彦: "インターフェロン-その研究の歩みと臨床応用への可能性-" ライフサイエンス, 211 (1998)

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  • [Publications] 堀 哲郎: "麻酔科医のための生理学" 真興交易医書出版(印刷中), (1999)

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  • [Publications] 片渕俊彦: "免疫学からみた神経系と神経疾患" 日本医学館(印刷中), (1999)

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      1998 Annual Research Report
  • [Publications] 片渕俊彦: "ストレスの事典" 朝倉書店(印刷中), (1999)

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      1998 Annual Research Report
  • [Publications] Ota,K.: "The AV3V neurons which send axons to hypothalamic nuclei respond to the systemic injection of IL-1 β." Am.J.Physiol.272. R532-R540 (1997)

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  • [Publications] Li,A.J.: "Interleukin-6 inhibits long-term potentiation in rat hippocampal slices." Brain Res.748. 30-38 (1997)

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      1997 Annual Research Report
  • [Publications] Oka,T.: "Biphasic alteration in the trigeminal nociceptive neuronal responses after intracerebroventricular injection of prostaglandin E2 in rats." Brain Res.749. 354-357 (1997)

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  • [Publications] Katafuchi,T.: "Differential effects of tumor necrosis factor-α and -β on the rat ventromedial hypothalamic neurons in vitro." Am.J.Physiol.272. R1966-R1971 (1997)

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  • [Publications] Hosoi,M.: "Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca in rats." Pain. 71. 303-311 (1997)

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  • [Publications] Oka,K.: "Prostaglandin E2 may induce hyperthermia through EP1-receptors in the anterior wall of the third ventricle and neighboring preoptic regions." Brain Res.767. 92-99 (1997)

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      1997 Annual Research Report
  • [Publications] Hori,T.: "Cell biology and the functions of thermosensitive neurons in the brain." Prog.Brain Res.115. 9-23 (1997)

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  • [Publications] Shiramine,K.: "Lateral hypothalamic injection of GABAA antagonist induces gastric vagus-mediated hypocalcemia in the rat." Am.J.Physiol.273. R1492-R1500 (1997)

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      1997 Annual Research Report
  • [Publications] Oka,T.: "Biphasic modulation in the trigeminal nociceptive neuronal responses by the intracerebroventricular prostaglandin E2 may be mediated through different EP receptors subtype in rats." Brain Res.771. 278-284 (1997)

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  • [Publications] Katafuchi,T.: "Sequential relationship between actions of CRF and PGE2 in the brain on splenic sympathetic nerve activity in rats." J.Auton.Nerv.Syst.67. 200-206 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hori,T.: "Pain modulatory actions of cytokines and PGE2 in the brain." Ann.New York Acad.Sci.840. 319-334 (1997)

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  • [Publications] 堀 哲郎: "ストレスとNeuroimmunomodulation" 日本集中治療医学会雑誌. 4. 3-9 (1997)

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  • [Publications] 堀 哲郎: "自律神経系による免疫系制御" Clinical Neuroscience. 15. 394-396 (1997)

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  • [Publications] 堀 哲郎: "発熱の科学" 救急医学. 21. 1000-1015 (1997)

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  • [Publications] 堀 哲郎: "怒りはどこから湧き、どのように発散されるか" COMMUNICATION. 68. 12-15 (1997)

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  • [Publications] Li,A-J.: "A single pre-training glucose injection induces memory facilitation in rodents performing various tasks:contribution of acidic fibroblast growth factor." Neuroscience. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hori,T.: "Neuroimmunomodulatory actions of hypothalamic interferon-α." Neuroimmunomodulation. 5(in press). (1998)

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      1997 Annual Research Report
  • [Publications] 堀 哲郎: "サイトカインと脳・免疫連関" Clinical Neuroscience. 16(in press). (1998)

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  • [Publications] 堀 哲郎: "脳・免疫系連関における伝達物質" Clinical Neuroscience. 16(in press). (1998)

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  • [Publications] 堀 哲郎: "最新内科学大系プログレスシリーズ2「内分泌・代謝疾患」" 中山書店, 419 (1997)

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  • [Publications] Oka,T.: "Brain cytokines and pain." Birkhaeuser Publishing Ltd(in press), (1998)

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  • [Publications] 堀 哲郎: "脳機能の解明-21世紀に向けて" 九州大学出版会(in press), (1997)

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Published: 1997-04-01   Modified: 2016-04-21  

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