| Project/Area Number |
09557070
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Radiation science
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| Research Institution | Kobe University (1999)
Shimane Medical University (1997-1998) |
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Principal Investigator |
SUGIMURA Kazuo Kobe University, School of Medicine, Professor, 医学部, 教授 (00136384)
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| Co-Investigator(Kenkyū-buntansha) |
KURODA Kagayaki Research institute of Science and Technology, Tokai University, Lecturer, 総合科学技術研究所, 講師 (70205243)
KATO Hirokazu Okayama University, School of Medicine, Department of Health Science, Professor, 医学部, 教授 (60127511)
KASAI Toshifumi Kyoto College of Medical Technology, Lecturer, 講師 (70194701)
YAMASAKI Katsuhito Kobe University, Hospital, Department of Radiology, Lecturer, 医学部・附属病院, 講師 (50210381)
UCHIDA Nobue Shimane Medical University, Department of Radiology, Assistant Professor, 医学部, 助手 (80304260)
杉原 正樹 島根医科大学, 医学部, 助手 (80187658)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1997: ¥5,100,000 (Direct Cost: ¥5,100,000)
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| Keywords | hyperthermia / RF heating / hyperhtermo-radiotherapy / remote after loading system / interstitial heating / magnetic resonance imaging / roton chemical shift / temperature monitoring / Remote After Loading System (RALS) |
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| Research Abstract |
The technique of a non-invasive, real-time monitoring of the temperature change distribution has been one of the desired methods in performing hyperthermia treatment. The purpose of this study was to estimate the feasibility of temperature mapping using the phase mapping method during RF interstitial hyperthermia with a very low magnetic field(0.2-T) using phantoms and animals.
The experiments were performed with a 0.2-T MR unit for interventional radiology using a head surface coil. Vegetable oil containers were used as comparative substance to observe the magnetic field deviation. The chemical shift change was measured with the phase mapping method using a gradient echo process. For RF interstitial hyperthermia, the power was supplied by a RF generator, which was driven at a frequency between 9.0 and 13.5 MHz, with the power of 2 to 7 W. (1)The spatial distribution of the magnetic field fluctuation : measured as phase difference distribution in an oil phantom. The spatial resolution was 1.56 x 1.56 x 5 mm3. (2)To obtain the temperature coefficient, 4.5mM CuSO4 solution phantoms were warmed up to 80℃ by microwave, then the phase difference images were processed during the cooling. The temperature coefficient obtained was -0.0096 ppm/℃. (3)Anesthetized and immobilized five New Zealand- White rabbits were used to confirm the efficacy of this system. The interstitial electrode was inserted into the rabbit's thigh. The RF power supply and temperature processing were performed alternately. The reconstructed temperature images were processed in 5 seconds.
Feasibility of the temperature change distribution imaging with the 0.2-T open MR system with a quasi-real-time processing was demonstrated. The results shown in the present study suggest the possibility of clinical applications of such low-end field scanners to monitor the internal body temperature during RF interstitial hyperthermia.
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