| Project/Area Number |
09557107
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Tokyo |
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Principal Investigator |
KOTSUKA Yutaka University of Tokyo, Cardiothorathic Surgery, Associate Prof., 医学部・附属病院, 助教授 (10126055)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Hiroyuki Ube Industry Ltd, Polymer Laboratory, Chief Stuff of Research, 高分子研究所, 主席研究員
ONO Minoru University of Tokyo, Cardiothorathic Surgery, Assistant, 医学部・附属病院, 助手 (40270871)
EZURE Masahiko University of Tokyo, Cardiothorathic Surgery, Assistant, 医学部・附属病院, 助手 (20282642)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥11,900,000 (Direct Cost: ¥11,900,000)
Fiscal Year 1998: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1997: ¥8,000,000 (Direct Cost: ¥8,000,000)
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| Keywords | stentgraft repair / endovascular surgery / aortic aneurysm / ultrathin-wall vascular graft / wall thickness of vascular graft / tensile strength / water permeability / ステント・グラフト |
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| Research Abstract |
OBJECTIVES : It is sometimes impossible to perform endovascular stent-graft repair through the peripheral artery because of the mismatch in size between the introducer and the peripheral artery. The purpose of this study is to develop ultrathin-wall grafts suitable for stent-graft procedures performed through the peripheral artery. METHODS : We fabricated ultrathin-wall grafts with a wall thickness of 42 to 137mum, using 50 denier polyester threads consisting of 72 polyester monofilaments. We studied the physical properties of the ultrathin-wall grafts in in vitro experiments. 1) The surface structure of the grafts was examined by electron microscopy. The planimetric porosity of the grafts was determined through measuring the areas of voids from electrophotomicrographs. 2) The longitudinal tensile strength of the grafts was determined with a tensile strength machine. 3) The water permeability of the grafts was measured. 4) We examined the size of introducers through which stent-grafts assembled with a Gianturco Z-stents and the ultrathin-wall grafts could pass. RESULTS : 1) In ultrathin-wall grafts with a wall thickness of 75mum or more, a regular surface structure with zero planimetric porosity was recognized. In those with a thickness less than 64mum, the porosity increased as the wall thickness decreased. 2) The longitudinal tensile strengths of the 75mum and 64mum grafts were 13.1*0.9 Kg and 9.5*0.9 Kg, respectively. 3) The water permeability of the 75mum grafts was 380 ml/min, and that of the thinner grafts increased rapidly as the wall thickness decreased. 4) Stents covered with the ultrathin-wall grafts could pass through introducers with a diameter of 18 French. CONCLUSIONS : We conclude that the newly developed ultrathin-wall grafts are suitable for endovascular surgery.
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