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BRAIN TEMPERATURE AND BRAIN DAMAGE INDUCTION DURING BRAIN ISCHEMIA AND HYPOXIA IN FETAL SHEEP.

Research Project

Project/Area Number 09557133
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Obstetrics and gynecology
Research InstitutionNIPPON MEDICAL SCHOOL

Principal Investigator

ARAKI Tsutomu  NIPPON MEDICAL SCHOOL,OBSTETRICS AND GYNECOLOGY,PROFESSOR, 医学部, 教授 (40089751)

Co-Investigator(Kenkyū-buntansha) SUZUKI Shunji  NIPPON MEDICAL SCHOOL,OBSTETRICS AND GYNECOLOGY,INSTRUCTOR, 医学部, 助手 (80291722)
SAWA Rintaro  NIPPON MEDICAL SCHOOL,OBSTETRICS AND GYNECOLOGY,ASSISTANT PROFESSOR, 医学部, 講師 (30267174)
YONEYAMA Yoshio  NIPPON MEDICAL SCHOOL,OBSTETRICS AND GYNECOLOGY,ASSISTANT PROFESSOR, 医学部, 講師 (00201096)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 1999: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1998: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥3,100,000 (Direct Cost: ¥3,100,000)
Keywordsbrain ischemia / brain hypoxia / fetal sheep / brain hypothermia / adenosine / theophylline / glucose / lactate / 脳低温療法 / 胎児 / 脳温 / 脳障害
Research Abstract

[PURPOSE] The purpose of this study is to evaluate the relationship between changes in brain temperature and induction of brain damage during brain ischemia and hypoxia in fetal sheep.
[METHOD] We inducted fetal brain ischemia and hypoxia, then measured brain temperature and induction of brain damage in six chronically instrumented fetal sheep.
[RESULTS] Fetal brain hypoxia and ischemia elicited brain damage, which was partially diminished by the slow induction of mild hypothermia.
[CONCLUSION] The slow induction of mild hypothermia prevents the induction of fetal brain damage during brain ischemia and hypoxia in fetal sheep.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Kubonoya K, et al: "Brain temperature and metabolic responses to cord occlusion in fetal sheep"Pflug Arch Eur J. Phy. 436. 667-72 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoneyama Y, et al: "Evidence for mechanisms of acute phase response to endotoxin in late-gestation fetal goats"Am J. Obstet Gynecol. 179. 750-755 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suzuki S, et al: "Maternal plasma adenosine levels in pregnancies complicated by toxemia"Trophoblast Res. 13. 407-414 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kijima K, et al: "Effect of fetal endotoxin administration on plasma prostaglandin F and cortical levels in late gestation fetal goats"Fetal Ding Three. 14. 240-243 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoneyama Y, et al: "Plasma adenosine levels increase in normal pregnant women"Am. J. Obstet Gynecol. (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suzuki S, et al: "Role of adenosine in regulation of brain temperature in fetal sheep"Am. J. Obstet Gynecol. 181. 681-684 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kubonoya K. et al: "Brain temperature and metabolic responses cord occulusion in fetal sheep."Plug Arch Eur J Phy. 436. 667-672 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoneyama Y. et al: "Evidence for mechanisms of acute phase response to endotoxin in late-gestation fetal goats."Am J Obstet Gynecol. 179. 750-755 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suzuki S. et al: "Maternal plasma adenosine levels in pregnancies complicated by toxemia."Trophoblast Res. 13. 407-414 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kijima K. et: "Effect of fetal endotoxin administration on plasma prodtaglandin F and cortisol levels in late gestation fetal goats"Fetal Diagn Ther. 14. 240-243 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoneyama Y. et al: "Plasma adenosine levels increase in normal pregnant women."Am J Obstet Gynecol. (in printing). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suzuki S. et al: "Role of adenosine in regulation of brain temperature in fetal sheep."Am J Obstet Gynecol. 181. 681-687 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoneyama Y. et al: "Plasma adenosine levels increase in normal pregnant women."Am J Obstet Gynecol. (印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suzuki S. et al: "Clinical trial of induction of labor versus expectant management in twin pregnancy"Gynecol Obstet Invest. 49・61. 24-27 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suzuki S. et al: "Amniotic band syndrome in triplet pregnancy"Fetal Diagn Ther. 14・6. 351-353 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Otsubo Y. et al: "Evaluation of the umbilical cord insertion with umbilical cord index of ultrasography"J Clin uttra sound. 27・6. 341-344 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suzuki S. et al: "Iatrogenic monoamniotic twin gastation with progressive twin-twin syndrome"Fetal Diagn Ther. 14・2. 98-101 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Otsubo Y. et al: "Fetal brain death and Dandy-Walker malformation"Prenat Diagn.. 19. 777-779 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.Kubonoya, et al.: "Brain temperature and metabolic responses during umbilical cord occlusion in fetal sheep" Dflug Arch Eur J Phy. 436・5. 667-672 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] R.Sawa, et al.: "Fetal plasma hypoxanthine level in growth-retarded fetus before labor" J.Clin.Endocrinol.Metab.82・12. 4028-4031 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Yoneyama, et al.: "Evidence for mechanisms of the acute-phase response to endotoxin in late-gestation fetal goats" Am.J.Obstet Gynecol. 179・3. 750-5 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] S.Suzuki, et al.: "Role of adenosine in regulation of brain temperature in fetal sheep" Am.J.Obstet Gynecol. 181 in printing. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Kijima, et al.: "Effect of fetal endotoxin administration on plasma prostaglandin F2α and corticol lelvels in late gestation fetal goats" Fetal Diagn Ther. 757 in printing. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Kuhonoya: "Cord Malondialdehyde level in growth-retarded fetuses hefore labor" Acta Obstetrica et Gynecologica Scandinavica. 76・167. Supplement 62 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] R.Sawa: "Fetal plasma hypoxanthine level in growth-retarded fetuses before labor" J.Clin.Endocrinol.Metab.82・12. 4028-4031 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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