• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Dental Application of Bisphosphonates

Research Project

Project/Area Number 09557142
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Functional basic dentistry
Research InstitutionTohoku University

Principal Investigator

SHINODA Hisashi  School of Dentistry, Tohoku University Professor, 歯学部, 教授 (80014025)

Co-Investigator(Kenkyū-buntansha) KAWAUCHI Akihiko  Proctor and Gamlole Far East Inc., Department of Research and Development Manage, アンド・ギャンブル・ファー・イースト・インク社研究開発本部分析・テク, 課長(研究職)
IGARASHI Kaoru  School of Dentistry, Tohoku University Research Associate, 歯学部, 助手 (70202851)
HORIUCHI Hiroshi  School of Dentistry, Tohoku University Professor, 歯学部, 教授 (00013962)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 1998: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1997: ¥3,100,000 (Direct Cost: ¥3,100,000)
KeywordsBisphosphonates / Periodontitis / Bone Resorption / Topical Application / Osteoclasts / Orthodontics / Tooth movement / クロドロネート / ビスホスホネート / リセドロネート
Research Abstract

We have reported that systemic administration of bisphosphonates could prevent alveolar bone resorption in rats with experimental periodontitis. We have also reported that both systemic and topical administration of bisphosphonates have potent anchorage and retentive effects on the orthodontic tooth movement in rats. These results suggest that bisphosphonates could be useful agents in the various dental therapies in which prevention of alveolar bone resorption is essential. However, when clinical dental application of bisphosphonates is considered, localized use at specific local site of alveolar bone without systemic effect would be desirable, since normal systemic bone metabolism should not be affected by the local dental therapies. The objectives of the present study were (1) to determine whether topical administration of bisphosphonates is effective on the prevention of alveolar bone resorption incident to periodontitis or orthodontic tooth movement and (2) to clarify the mode of preventive action of bisphosphonates on the bone resorption. The following results were obtained. (1) Topical injection of clodronate or risedronate into the sub-periosteum area adjacent to target teeth were effective in preventing bone resorption incident to periodontitis or orthodontic tooth movement in rats. (2) Iontophoretic administration of risedronate were also effective in the prevention of alveolar bone loss in the periodontitis, but the effect was small. (3) The inhibitory action of bisphosphonates on bone resorption is not due to the inhibition of osteoclast recruittment, but rather to the inhibition of osteoclast function, such as an induction of apoptosis and inhibition of acid phosphatase.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] K.Igarashi, M.Hirafuji, H.Adachi, H.Shinoda, H.Mitari: "Effects of bisphosphonates on alkalinephosphatase activity, mineralization, and prostaglandin E_2 Synthesis in clonal osteoblast-like cell line MC3T3-E1." Prostaglandines, Leukotriens and Essential Fatty acids. 56(2). 121-125 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 篠田 壽: "骨代謝の時間薬理学" Molecular Medicine. 34(3). 310-321 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 五十嵐 薫: "ビスフォスフォネートの局所適用法の開発と歯科的応用への可能性" ファルマシア. 35(3). 263-264 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Shinoda, K.Ohya: "Effects of bisphosphonates on osteoclastkinetics in vivo and in vitro" Japanese Journal of Pharmacology. 79(Supple). 13P- (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 鹿島勇,野口俊秀,俣木志朗,篠田壽 他5名: "骨粗鬆に関する歯学からのアプローチ -診断ならびに歯周疾患との関係-" 日本歯科医学会誌. 18巻(1). 53-63 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Sakamoto, S.Sassa, H.Shinoda et al.: "Prevention of osteopenia a gonadtropine-releasing hormone agonist in rats." Calcified Tissue International. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 篠田壽,稲葉雅彦,森井浩世: "ビスフォスフォネートと骨疾患(第二版)" 医歯薬出版, 183 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Igarashi, M.Hirafuji, H.Adachi, H.Shinoda, H.Mitani: "Effects of bisphosphonates on alkaline Phosphatase ctivity, minelarization, and Prostaglandin E_2 Synthesis in the clonal osteoblast-like cell line MCT3-E1" Prostaglandines, Leukotriens and Essential Fatty Acids. 56 (2). 121-125 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hisashi Shinoda: "Chronopharmacology in bone metabolism" Molecular Medicine. 34 (3). 310-321 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kaoru Igarashi: "Topical application of bisphosphonates for dental use" Pharmacia. 35 (3). 263-264

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Shinoda, K.Ohya: "Effects bisphosphonates on osteoclast kinetics in vivo and in vitro" Japanese Journal of Pharmacology. 79 (Supple). 13 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Kashima, A.Taguchi, T.Noguchi, M.Fukuda, K.Inagaki, T.Sakai, H.Shinoda, S.Mataki, N.Kurosaki: "A dental approach to osteoporosis" Nihon Shika-igakukai Shi. 18. 53-63 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Sakamoto, S.Sassa, T.Mitamura, H.Kudo, S.Suzuki, S.Yoshimura, Y.-F.Zhou, T.Kikuchi, H.Shinoda: "Prevention of osteopenia induced wiht a gonadotropin releasing hormone agonist in rats." Calcified Tissue International. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Mitsuta, H.Horiuchi, H.Shinoda: "Inhibitory effects of topical application of a bisphosphonate (clodronate) on experimental preiodontitis in rats" Journal of Dental Research. (to be submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 五十嵐 薫: "ビスフォスフォネートの局所適用法の開発と歯科的応用への可能性" ファルマシア. 35巻3号. 263-264 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Shinoda,K.Ohya: "Effects of bisphosphonates on osteoclast kinetics in vivo and in vitro." The Japanese Journal of Pharmacology. Vol.79(supple). 13P (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] S.Sakamoto,S.Sassa,H.Shinoda et al.: "Prevention of osteopenia induced with a gonadotropin-releasing hormone agonist in rats." Calcified Tissue International. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Igarashi, H.Shinoda et al.: "Effects of bisphoshonates on alkaline phosphatase activity,meneralization,and prostaglandin E_2 synthesis in the clonal osteoldast-like cell line MC3T3-Ei." Prostaglandines,Leukotriens and Essential Fatty Acids.56巻2号. 121-125 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 篠田 壽: "骨代謝の時間薬理学" Molecular Medicine. 34巻3号. 310-321 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 篠田壽, 稲葉雅章, 森月浩世: "ビスフォスフォネートと骨疾患(第二刷)" 医歯薬出版, 183 (1997)

    • Related Report
      1997 Annual Research Report

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi