| Project/Area Number |
09557154
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyoto Prefectural University of Medicine(KPUM) |
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Principal Investigator |
HORI Nobutaka KPUM, Dept.of Med., Professor, 医学部, 教授 (10067019)
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| Co-Investigator(Kenkyū-buntansha) |
BABA Shunsuke KPUM, Dept.of Med., assistant Professor, 医学部, 助手 (40275227)
KANAMURA Narisato KPUM, Dept.of Med., lecturer, 医学部, 助手 (70204542)
TSUKITANI Kouji KPUM, Dept.of Med., lecturer, 医学部, 講師 (10121328)
UCHIYAMA Tatsumi NEC Medical System Co.Ltd.
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| Project Period (FY) |
1997 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥11,200,000 (Direct Cost: ¥11,200,000)
Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1998: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥6,000,000 (Direct Cost: ¥6,000,000)
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| Keywords | oral function / mastication / mandibular movements / brain activation / functionl MRI / MEG / Functional MRI / fMRI / Function MRI |
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| Research Abstract |
Masticatory movements is fundamentally characterized by its repeated rhythmical movements, and the rhythm of mastication is known to be controlled by the rhythm generator that exists in the central nervous system. Furthermore, sensory information from the peripheral nerve is also involved in controlling motor function in the masticatory system, which is thought to be the essence of the neuromuscular coordination related to the masticatory system. Although mapping of the area activated during a series of masticatory movements within the primary sensorimotor area known to control mandibular movement as well as sensation has previously been reported, changes in the activation state by clenching remains to be clarified. In this study, we examined the posibility of Development of analytical method of oral function in masticational cycle. Previous brain mapping studies on mastication were performed using positron emission tomography(PET), however, PET has a drawback concerning radiation exposure. Non-invasive functional magnetic resonance imaging(fMRI), which visualizes the functioning area in the brain, was use to determine blood oxygen level dependent(BOLD) signals, which are regarded as an index of functionally induced changes in the cerebral regional blood flow. Measurements of fMRI were performed on a conventional whole body 1.5T clinical scanner using a single shot, multislice echo-planar imaging sequence. And MEG were performed for determine cortex reaction of trigeminal nerve for lower lip. Six normal volunteers underwent fMRI and MEG during biting and favorite food imaging task. Image processing was performed using all pixels with significant signal intensity(SI) change determined from the fMRI data and MEG data. The findings showed that the SI significantly increased by biting task and favorite food imaging task. These findings suggest that fMRI and MEG were very useful analytical method for oral function research.
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