| Project/Area Number |
09557160
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Surgical dentistry
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
MOTEGI Katsutoshi School of Dentistry, Tohoku University, Professor, 歯学部, 教授 (60013984)
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| Co-Investigator(Kenkyū-buntansha) |
KAMAKURA Shinji School of Dentistry, Tohoku University, Research Associate, 歯学部, 助手 (80224640)
KATOU Fuminori School of Dentistry, Tohoku University, Assistant Professor, 歯学部・付属病院, 講師 (60204492)
KAGAYAMA Manabu School of Dentistry, Tohoku University, Professor, 歯学部, 教授 (60004610)
SUZUKI Osamu Research and Development Div., JGC Corp., Senior Researcher, 技術開発本部, 副主任研究員
SASANO Yasuyuki School of Dentistry, Tohoku University, Research Associate, 歯学部, 助手 (30196191)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 1999: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1998: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1997: ¥9,700,000 (Direct Cost: ¥9,700,000)
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| Keywords | Bone / Bone Formation / Bone Repair / Octacalcium Phosphate / Calcium Phosphate |
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| Research Abstract |
We hypothesized that octacalcium phosphate (OCP) can be used as an effective bone substitute. The present study was designed to investigate if bone repair is enhanced when OCP is implanted and which cell population is involved in bone formation caused by the OCP implantation. The OCP was prepared according to the method by LeGeros. Ground granules of between 32 and 48 mesh (particle sizes: 300 to 500 μm) were used for the implantation. The OCP was implanted into the bone marrow, the subperiosteal region and the standardized trephine defect of parietal bones in rats.
The following were suggested from the results of our experiments. First, the implanted OCP could be resorbed by multinucleated giant cells which share some ultrastructural characteristics with osteoclasts. Second, the implanted OCP may act on osteoblasts, bone lining cells and/or their closely committed progenitors on the bone surface to express the phenotype and deposit new bone around the OCP. Third, the implanted OCP may serve as a core for initial bone formation in the defect and promote bone repair. The present studies demonstrated that OCP can be used as an effective bone substitute.
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