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The mechanism of atrophy in skeletal muscle with aging

Research Project

Project/Area Number 09558002
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 体育学
Research InstitutionUniversity of Tsukuba

Principal Investigator

KATSUTA Shigeru  Institute of Health and Sport Sciences, University of Tsukuba Professor, 体育科学系, 教授 (70038446)

Co-Investigator(Kenkyū-buntansha) KUNO Shin-ya  Institute of Health and Sport Sciences, University of Tsukuba Assistant Professor, 体育科学系, 講師 (70242021)
ISHIHARA Akihiko  Faculty of Integrated Human Studies, Kyoto-University. Professor, 総合人間学部, 教授 (90184548)
HAYASHI Jun-ichi  Institute of Biological Sciences, University of Tsukuba Professor, 生物科学系, 教授 (60142113)
TAKAHASHI Hideyuki  Japan Institute of Sports Sciences, Research Scientist, 国立スポーツ科学センター, 研究員 (00292540)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 1999: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1998: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1997: ¥6,800,000 (Direct Cost: ¥6,800,000)
Keywordsaging / muscle atrophy / exercise / muscle cross-sectional area / mitochondorial DNA / motoneurons / 筋代謝
Research Abstract

The aim of this study was to elucidate the mechanism of skeletal muscle changes with aging and exercise training.
In animal study, we were conducted to determine the effects of acute exercise on mitochondorial DNA and the structure of skeletal muscles. We detected the large-scale deletion of mitochondrial DNA by the nested polymerase chain reaction, and also observed mitochondrial ultrastructural changes in the soleus muscle.
Effects of exercise-training on succinate dehydrogenase (SDH) activities and cross-sectional areas (CSAs) of fibers in senescence-accelerated mice (SAMP6) were investigated. Atrophy and decreased SDH activity of fibers in the muscle were observed at 60 weeks of age. Exercise training could not inhibit age-related fiber atrophy of the muscle. This study is suggested that no inhibition of fiber atrophy during aging is due to low-intensity running that could not recruit fast-twitch and low-oxidative fibers.
In human study, we measured separately for extensor and flexor groups the change in cross-sectional thigh muscle area across the range of ages from twenties to eighties at the intervals of 10 years. The results of this study indicate that muscle atrophy due to aging takes place only at extensor groups but flexor groups are hardly affected by aging and that there is sex difference in the degree of atrophy dut to aging.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Hirofuji C.et al.: "SDH activity and cell size of tibialis anterior motoneurons and muscle fibers in SAMP6"Neuro Report. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasukawa T.et al.: "Stability of mitochondrial tRNA molecules with pathogenic point mutations"Nucleic Acids Symposium Series. 39. 257-258 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuoka R.et al.: "A mitochondrial DNA mutation co-segregates with the pathophysiological U wave"Biochem.Biophys.Res.Commun.. 257. 228-233 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takai D.et et al.: "Transcomplementation between different types of respiration-deficient mitochondria with different pathogenic mutant mitochondrial DNAs"J.Biol.Chem.. 274. 11199-11202 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ito S.et al.: "Functional integrity of mitochondrial genomes in human plantelets and autopsied brain tissues from aged patients with Alzheimer's disease"Proc.Natl.Acad.Sci.USA. 96. 2099-2103 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakai Y.et al.: "Acute exercise causes mitochondrial DNA deletion in rat skeletal muscle"Muscle & Nerve. 22. 258-261 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hirofuji, C., et al.: "SH activity and cell size of tibialis anterior motoneurons and muscle fibers in SAMP6"NeuroReport. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasukawa, T., et al.: "Stability of mitochondrial t DNA molecules with pathogenic point mutations"Nucleic Acids Symposium Serius. 39. 257-258 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuoka, R., et al.: "A mitochondrial DNA mutation co-segregates with the pathophysiological U wave."Biochem. Biophys. Res. Commun.. 257. 228-233 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takai, D., et al.: "Transcomplementation between different types of respiration-deficient mitochondria with different pathogenic mutant mitochondrial DNAs"J. Biol. Chem.. 274. 11199-11202 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ito, S., et al.: "Functional integrity of mitochondrial genomes in human plantelets and autopsied brain tissues from aged patients with Alzheimer's disease"Proc. Natl. Acad. Sci. USA. 96. 2099-2103 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakai, Y., et al.: "Acute exercise causes mitochondrial DNA deletion in rat skeletal muscle"Muscle & Nerve. 22. 258-261 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hirofuji,C.,et al.: "SDH activity and cell size of tibialis anterior motoneurons and muscle fibers in SAMP6"NeuroReport,in press.

    • Related Report
      1999 Annual Research Report
  • [Publications] Yasukawa,T.,et al.: "Stability of mitochondrial t RNA molecules with pathogenic point mutations"Nucleic Acids Symposium Serius. 39. 257-258 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsuoka,R.,et al.: "A mitochondrial DNA mutation co-segregates with the pathophysiological U wave."Biochem.Biophys.Res.Commun.. 257. 228-233 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takai,D.,et al.: "Transcomplementation between different types of respiration-defficient mitochondria with different pathogenic mutant mitochondrial DNAs"J.Biol.Chem.. 274. 11199-11202 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ito,S.,et al.: "Functional integrity of mitochondrial genomes in human plantelets and autopsied brain tissues from aged patients with Alzheimer"Proc.Natl.Acad.Sci.USA. 96. 2099-2103 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sakai,Y.et al.: "Acute exercise causes mitochondrial DNA deletion in rat skeletal muscle"Muscle & Nerve. 22. 258-261 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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