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Development of low-energy proton irradiation system for radiobiology study of neutrons

Research Project

Project/Area Number 09558071
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 環境影響評価(含放射線生物学)
Research InstitutionHiroshima University

Principal Investigator

HOSHI Masaharu  Research Institute for Radiation Biology and Medicine, Hiroshima University, Professor, 原爆放射能医学研究所, 教授 (50099090)

Co-Investigator(Kenkyū-buntansha) NITTA Yumiko  Research Institute for Radiation Biology and Medicine, Hiroshima University, Research Associate, 原爆放射能医学研究所, 助手 (60171964)
TAKADA Jun  Research Institute for Radiation Biology and Medicine, Hiroshima University, Associate Professor, 原爆放射能医学研究所, 助教授 (00274134)
ENDO Satoru  Faculty of Engineering, Hiroshima University, Associate Professor, 工学部, 助教授 (90243609)
KIMURA Toshio  Nissan Electric Co., Ltd., Chief of Research, 研究課長
IWAMOTO Eiji  Nissan Electric Co., Ltd., Head of Research, 研究部長
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1997: ¥3,100,000 (Direct Cost: ¥3,100,000)
Keywordsneutron generator / energy spectrums / biological effect / accelerator / TOF / neutron
Research Abstract

Biological effects of neutrons are relatively large comparing with gamma rays and X rays. Their biological effects are not related directly to neutrons themselves but to the secondary charged particles, which were induced by neutrons. The factors are usually explained by "the relative biological effectiveness (RBE)" and are 7-10 times sometimes even 20 times larger than those of gamma rays and X rays. The reasons are that the 70 to 80% of the neutron doses are given by recoil protons. However, the experimental data of the RBE values of protons are 1.0 to 1.2, therefore our purpose of this study is to find the reason of the high RBE values of neutrons. We considered the possibility is in the protons when they loose energy and stop. At this moment the RBE values may become very high. To verify this assumption we used 3 MeV accelerator (HIRRAC) at Research Institute for Radiation Biology and Medicine, Hiroshima University, which was installed in 1995. We made proton beam extraction window from vacuum to air using a 5 micron meter thick Mylar foil or 2.2 micron meter Harvar alloy foil. To measure proton beam to estimate doses, we used plastic scintillation counter. The whole system was successful. We extracted proton beam and measured proton beam energy and fluence. The final purpose of the study was to make biological experiment using cells, however, the exposure system is now under construction and planning to perform the experiment. We are making effort to complete this study.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report

Research Products

(40 results)

All Other

All Publications (40 results)

  • [Publications] 星 正治: "チェルノブイリ周辺地域での医療協力と調査研究に携わって"原安協だより. 160. 18-20 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J.Takada: "Environmental Radiation Dose in Semipalatinsk Area near Nuclear Test Site"Health Physics. 73. 524-527 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Shizuma: "Identification of ^<63>Ni and ^<60>Co produced in a steel sample by themal neutrons from the Hiroshima atomic bomb"Nucl.Instrum.Methods Phys.Res.A. 389. 375-379 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Shizuma: "^<152>Eu depth profiles in garanite and concrete cores exposed to the Hiroshima Atomic Bomb"Health Physics. 72. 848-855 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Hoshi: "Problems of Radiation Dose Evaluation in Hiroshima and Nagasaki and their Explanation"Radiation Protection Dosimetry. 77. 15-23 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Nikjoo: "Track structure in radiation biology:theory and applications"Int.J.Radiat.Biol.. 73. 355-364 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] I.Yoshikawa: "Relative biological effectiveness of accelerated carbon ions with different LET for the induction of somatic mutations in Drosophila larvae"1997 Annual Report Research Project with Heavy Ions at NIRS-HIMAC. 253-258 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] I.Yoshikawa: "The relalive biological effectiveness of accelerated carbon ions with different LET for inducing mitotic crossing over and intragenic reversion of the white-ivory allele in Droscphila larvae"Int.J.Biol.. 74. 239-248 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 星 正治: "軟X線の線量測定"医療標準線量. 4(1). 17-22 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 遠藤 暁: "C-Co_2電離箱(IC17G)の中性子感度の測定"医療標準線量. 4(1). 29-33 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.Endo: "DS^<86> Neutron Dose:Monte Carlo Analysis for Depht Profile of ^<152>Eu activity in a Large Stone Sample"J.Radiat.Res.. 40. 169-181 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.Endo: "Reduction of the gamma-ray component from ^<252>Cf fission neutron source-optimization for biological irradiations and comparison with MCNP code"Phys.Med.Biol.. 44. 1207-1218 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] I.Yoshikawa: "The Induction of Somatic Mutation by High-LET Radiation Observed Using the Drosophila Assay System"Risk Evaluation of Cosmic-Ray Exposure in Long-Term Manned Space Mission (ed.by K Fujitaka et al.). 88-99 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M, Hoshi: "Joining in the medical health care project and research studies for the people in Chernobyl area"Information from Radiation Safety Society. 160. 18-20 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J, Takada: "Environmental Radiation Dose in Semipalatinsk Area near Nuclear Test Site"Health Physics. 73. 524-527 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Shizuma: "Identification of ィイD163ィエD1Ni and ィイD160ィエD1Co produced in a steel sample by thermal neutrons from the Hiroshima atomic bomb"Nucl. Instrum. Methods Phys. Res.. 389. 375-379 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Shizuma: "ィイD1152ィエD1Eu depth profiles in garanite and concrete cores exposed to the Hiroshima Atomic Bomb"Health Physics. 72. 848-855 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Hoshi: "Problems of Radiation Dose Evaluation in Hiroshima and Nagasaki and their Explanation"Radiation Protection Dosimetry. 77. 15-23 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H, Nikjoo: "Track structure in radiation biology: theory and applications"Int. J. Radiat. Biol.. 73. 355-364 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] I. Yoshikawa: "Relative biological effectiveness of accelerated carbon ions with different LET for the induction of somatic mutations in Drosophila larvae"1997 Annual Report Research Project with Heavy Ions at NIRS-HIMAC. 253-258 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] I. Yoshikawa: "The relative biological effectiveness of accelerated carbon ions with different LET for inducing mitotic crossing over and intragenic reversion of the white-ivory allele in Drosophila larvae"Int. J. Biol.. 74. 239-248 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Hoshi: "Dosimetry of ultrasoft X-rays"Medical Standard Dose. 4(1). 17-22 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S, Endo: "Neutron sensitivity measurements for C-C02 ionization chamber"Medical Standard Dose. 4(1). 29-33 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S, Endo: "DS86 Neutron Dose: Monte Carlo Analysis for Depth Profile of ィイD1152ィエD1Eu Activity in a Large Stone Sample"J Radiat. Res.. 40. 169-181 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S. Endo: "Reduction of the gamma-ray component from ィイD1252ィエD1Cf fission neutron source - optimization for biological irradiations and comparison with MCNP code"Phys. Med. Biol.. 44. 1207-1218 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] I. Yoshikawa: "The Induction of Somatic Mutation by High-LET Radiation Observed Using the Drosophila Assay System"Risk Evaluation of Cosmic-Ray Exposure in Long-Term Manned Space Mission (ed. by K Fujitaka et al.). 89-99 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 星正治: "軟X線の線量測定"医療標準線量. 4(1). 17-22 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 遠藤暁: "C-C_<O2>電離箱(IC17G)の中性子感度の測定"医療標準線量. 4(1). 29-33 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] S.Endo: "DS86 Neutron Dose:Monte Carlo Analysis for Depth Profile of ^<152>Eu Activity in a Large Stone Sample"J.Radiat.Res.. 40. 169-181 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] S.Endo: "Reduction of the gamma-ray component from ^<252>Cf fission neutron source-optimization for biological irradiations and comparison with MCNP code"Phys.Med.Biol.. 44. 1207-1218 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] I.Yoshikawa: "The Induction of Somatic Mutation by High-LET Radiation Observed Using the Drosophila Assay System"Risk Evaluation of Cosmic-Ray Exposure in Long-Term Manned Space Mission(Ed.by K Fujitaka et al.). 89-99 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Hoshi: "Problems of Radiation Dose Evaluation in Hiroshima and Nagasaki and their Explanation" Radiation Protection Dosimetry. 77. 15-23 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Nikjoo: "Track structure in radiation biology:theory and applications" Int.J.Radiat.Biol.73. 355-364 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] I.Yoshikawa: "The relative biological effectiveness of accelerated carbon ions with different LET for inducing mitotic crossing over and intragenic reversion of the white-ivory allele in Drosophila larvae" Int.J.Biol.74. 239-248 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] I.Yoshikawa: "Relative biological effectiveness of accelerated carbon ions with different LET for the induction of somatic mutations in Drosophila larvae" 1997 Annual Report Research Project with Heavy Ions at NIRS-HIMAC. 253-258 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Hoshi: "Problems of Radiation Dose Evaluation in Hiroshima and Nagasaki and Their Explanation" Radiation Protection Dosimetry. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] 星 正治: "チェルノブイリ周辺地域での医療協力を調査研究に携わって" 原安協だより. 160. 18-20 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Shizuma: "^<152>Eu depth profiles in garantie and concrete cores exposed to the Hiroshima Atomic Bomb" Health Physics. 72. 848-855 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Shizuma: "Identification of ^<63>Ni and ^<60>Co produced in a steel sample by thermal neutrons from the Hiroshima atomic bomb" Nucl.Instrum.Methods Phys.Res.A. 389. 375-379 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] J.Takada: "Environmental Radiation Dose in Semipalatinsk Area near Nuclear Test Site" Health Physics. 73. 524-527 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-03-31   Modified: 2016-04-21  

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