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Establishment of a novel technology for the bone strength diagnosis by an ultrasonic method

Research Project

Project/Area Number 09559015
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 広領域
Research InstitutionDoshisha University

Principal Investigator

OTANI Takahiko  Doshisha University, Faculty of Engineering, Department of Electrical Engineering, Professor, 工学部, 教授 (50066205)

Co-Investigator(Kenkyū-buntansha) SUZAKI Takuji  HORIBA, Ltd. Research and Development Center, Senior Manager, 開発センター, シニアマネージャー
TAKAI Shinro  Kyoto Prefectural University of Medicine, Department of Orthopaedi Surgery, Lecturer, 医学部, 講師 (10226730)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1998: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1997: ¥6,300,000 (Direct Cost: ¥6,300,000)
KeywordsCancellous bone / Trabecular structure / porous structure / Biot's theory / fast wave / slow wave / Ultrasonic wave speed / Ultrasonic wave attenuation
Research Abstract

1. Analysis of the propagation phenomenon of ultrasonic wave in cancellous bone.
The cancellous bone is comprised of a complex porous network of numerous solid trabecular elements. Trabecular elements are almost aligned in the direction of stress. We have discovered a peculiar phenomenon of ultrasonic waves, i.e. two longitudinal waves (a fast wave and a slow wave) exist in cancellous bone. This peculiar phenomenon have been analyezed in detail in this research project.
Results of analytical and experimeutal studies in the research project show a strong possibility for the estimation of cancellous bone density and of microscopic trabecular structure based on the frequency characteristics of the propagation speed and attenuation for both fast and slow waves. The results mean that atrophy or morbid changes of cancellous bone can be evaluated.
2. Establishment of a new bone strength evaluation by ultrasonic method
A new method to measure the ultrasonic transfer function of cancellous bone is … More developed by taking into account the fast and slow waves. The density and elastic constant of cancellous bone have been non-invasively determined by the measured transfer functions and the measured propagation speeds. A further investigation is necessary to obtain numerical index of bone strength based on the elastic constant.
3. Development of wide-band high resolution ultrasonic transducer for medical applications.
The key device to realize a bone strength diagnosis system is the wide-band high resolution ultrasonic transducer. We have established during the project a theoretical basis on the impulse response and on the radiated acoustic field in the time domain, which are indispensable to develop and design the transducers and also established a calibration method and a fabrication method of transducers.
4. Future perspective of the researches.
The next stage of the researches is to establish a bone strength index based on the ultrasonic or elastic properties of bone and on the statistical analysis on huge clinical data and is also to be studied the acoustical imaging of bone density and bone strength. The next stage has already started by the support of the Grant-in-Aid for University and Society Collaboration of the Ministry of Education, Science, Sports and Culture. Less

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (54 results)

All Other

All Publications (54 results)

  • [Publications] A.HOSOKAWA,OTANI: "Ultrasonic wave propagation in bovine cancellous bone."Journal of the Acoustical society of America.. Vol.101 No.1. 558-562 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] E.FRIBOURG-BLANC,HOSOKAWA,OTANI: "Influence of viscosity of saturated fluid in cancellous bone on ultrasonic wave propagation."Technical Report of the Instiite of Electronics Information and Communication Engineers.. US96-89. 1-8 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.HOSOKAWA,OTANI,SUZAKI,KUBO,TAKAI: "Influence of Trabecular structure on Ultrasonic Wave Propagation in Bovine Cancellous Bone."Japanese Journal of Applied Physics.. Vol.36 Pt.1,No.5B. 3233-3237 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.HOSOKAWA,OTANI,SUZAKI,KUBO,TAKAI: "Influence of Trabecular structure in Bone on Ultrasonic Wave Propagation."Proceedings of Ultrasonics World Congress (YOKOHAMA).. 368-369 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 久保恭臣,高井,平澤,細川,大谷: "海綿骨中の音響伝搬について"日本整形外科学会誌. Vol.71 No.8. 1540 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] E.CAMUS,MUKUDA,OTANI,WATANABE: "Influence of fluid viscosity on the propagation of ultrasonic waves in bovine encellous bone."Technical Report of the Institute of Electronics Information and Communication Engineers.. US97-85. 1-8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 須崎琢而: "超音波による海綿骨特性の測定"Readout (HORIBA Technical Reports).. No.16. 25-28 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.HOSOKAWA,OTANI: "Acoustical anisotropy in bovine cancellous bone."Journal of the Acoustical society of America.. Vol.103 No.5,Pt.1. 2718-2722 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.OTANI,HOSOKAWA: "Effects of the structural anisotropy and the porosity on ultrasonic wave propagation in bovine cancellous bone."Proceedings of 16th International Congress on Acoustics.. Vol.4. 2505-2506 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.KUBO,TAKAI,YOSHINO,HOSOKAWA,OTANI: "Ultrasonic wave propagation in bovine trabecular bone."Transactions of the 3rd Combined Meeting of the Orthopaedic Research Societies of USA, Japan, Canda and Europe.. 224 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 久保恭臣,吉野,高井,平澤,細川,大谷: "超音波の骨密度測定への応用に関する実験的研究-牛海綿骨の超音波の伝搬について-"日本臨床バイオメカニクス学会誌. Vol.19. 307-310 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 沖中潮広,竹中,垣下,大谷: "架橋ポリエチレンオキシドゲルの超音波伝搬特性と生体用音響カプラへの適用"Journal of Medical Ultrasonics.. Vol.25 No.11. 1059-1066 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 五條雅史,今泉,大谷,須崎,高井: "橈骨中の音波伝搬特性に関する研究"電子情報通信学会技術研究報告. US98-92. 1-8 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 荒井義之,竹中,高井,久保,平澤: "橈骨遠位端の超音波伝搬特性と骨強度の関連"中部整災誌. Vol.42. 279-280 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 久保恭臣: "海綿骨中の超音波伝搬特性に関する基礎的研究"京都府立医科大学雑誌. Vol.108 No.3. 421-433 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.UEBA,MATSUKAWA,OTANI: "Ultrasonic wave propagation in particle compounded gels."Japanese Journal of Applied Physics.. Vol.38 Pt.1,No.5B. 3023-3027 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.OTANI: "Physical principles and theoretical concepts of transient acoustic field."Japanese Journal of Applied Physics.. Vol.39 Pt.1,No.5B. 2888-2897 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.HOSOKAWA, T.OTANI: "Ultrasonic wave propagation in bovine cancellous bone"Journal of the Acoustical society of America. Vol.101, No.1. 558-562 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] E.FRIBOURG-BLANC, A.HOSOKAWA, T.OTANI: "Influence of viscosity of saturated fluid in cancellous bone ultrasonic wave propagation"Technical Report of the Institute of Electronics Information and Communication Engineers. US96-89. 1-8 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.HOSOKAWA, T.OTANI, T.SUZAKI, Y.KUBO, S.TAKAI: "Influence of Trabecular structure on Ultrasonic Wave Propagation in Bovine Cancellous Bone"Japanese Journal of Applied Physics. Vol.36, Pt.1, No.5B. 3233-3237 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.HOSOKAWA, T.OTANI, T.SUZAKI.Y.KUBO, S.TAKAI: "Influence of Trabecular structure in Bone on Ultrasonic Wave Propagation"Proceedings of Ultrasonics World Congress (YOKOHAMA). 368-369 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.KUBO, N.TAKAI, Y.HIRASAWA, A.HOSOKAWA, T.OTANI: "Ultrasonic wave propagation in trabecular bone (in Japanese)"The Journal of the Japanese Orthopaedic Association. Vol.71, No.8. 1540 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] E.CAMUS, K.MUKUDA, T.OTANI, Y.WATANABE: "Influence of fluid viscosity on the propagation of Ultrasonic Waves in bovine cncellous bone"Technical Report of the Institute of Electronics Information and Communication Engineers. US97-85. 1-8 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.SUZAKI: "Ultrasonic Measurement of Trabecular Bone Characteristics (in Japanese)."Readout (HORIBA Technical Reports). NO.16. 25-28 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.HOSOKAWA, T.OTANI: "Acoustical anisotropy in bovine cancellous bone"Journal of the Acoustical society of America. Vol.103, No.5, Pt.1.. 2718-2722 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.OTANI, A.HOSOKAWA: "Effects of the structural anisotropy and the porosity on ultrasonic wave propagation in bovine cancellous bone"Proceedings of 16th International Congress on Acoustics and 135 Meeting Acoustical Society of America. Vol.4. 2505-2506 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.KUBO, S.TAKAI, N.YOSHINO, A.HOSOKAWA, T.OTANI: "Ultrasonic waave propagation in bovine trabecular bone"Ultrasonic waave propagation in bovine trabecular bone. 224 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.KUBO, N.YOSHINO, S.TAKAI, Y.HIRASAWA, HOSOKAWA, OTANI: "Experimental study for the application of ultrasonic wave to the measurement of bone density-Ultrasonic wave propagation in bovine trabecular bone-(in Japanese)."Journal of Japanese Society for Clinical Biomecanics and Related Research. Vol.19. 307-310 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.GOJO, K.IMAIZUMI, T.OTANI, T.SUZAKI, S.TAKAI: "An examination of ultrasonic propagation in human radii (in Japanese)"Technical Report of the Institute of Electronics Information and Communication Engineers, US98-92. 1-8 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.OKINAKA, Y.TAKEUCHI, O.KAKISHITA, T.OTANI: "Ultrasonic Propagation Characteristics of a Cross-linked Polyethylene Oxide Gel and Its Application to an Acoustic Coupler"Journal of Medical Ultrasonics. Vol.25, No.11(in Japanese).. 1059-1066 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.ARAI, N.TAKENAKA, N.TAKAI, Y.KUBO, YHIRASAWA: "Relationship between bone mineral density and ultrasound propagation property in human ultradistal radius (in Japanese)."The Central Japan Journal of Orthopaedic Surgery & Traumatology. Vol.42. 279-280 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.KUBO: "Fundamental study for ultrasound propagation properties in cancellous bone (in Japanese)."Journal of Kyoto Prefectural University of Medicine. Vol.103, No.3. 421-433 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.UEBA, M.MATSUKAWA, T.OTANI: "Ultrasonic wave propagation in particle compounded gels"Japanese Journal of Applied Physics. Vol.38, Pt.1,5B. 3023-3027 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.OTANI: "Physical principles and theoretical concepts of transient acoustic field"Japanese Journal of Applied Physics. Vol.39, Pt.1, No.5B. 2888-2897 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.UEBA, M,MATSUKAWA ,T.OTANI: "Ultrasonic wave propagation in particle compounded gels."Japanese Journal of Applied Physics. 38,Pt1,5B. 3023-3027 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 荒井、竹中、高井、久保、平澤: "橈骨遠位端の超音波伝搬特性と骨強度の関連"中部整炎誌. 42.2. 279-280 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 久保恭臣: "海綿骨中の超音波伝搬特性に関する基礎的研究"京都府立医科大学雑誌. 108,3. 421-433 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 今泉邦雄、大谷、須崎: "海綿骨内の間隙流体成分の超音波伝搬特性に及ぼす影響"日本音響学会講演論文集. 3月. 903-904 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 今泉邦雄、大谷、須崎: "海綿骨中の超音波伝搬における波形とスペクトル成分"日本音響学会講演論文集. 3月. 905-906 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.OTANI: "Physical principles and theoretical concepts of transient acoustic field."Japanese Journal of Applied Physics. 39,Pt1,5B(掲載決定). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 五條雅史、今泉、大谷、須崎、高井: "橈骨中の音波伝搬特性に関する研究" 電子情報通信学会技術研究報告. US98-92. 1-8 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.OTANI, A.HOSOKAWA: "Effects of the structural anisotropy and the porosity on ultrasonic wave propagation in bovine cancellous bone" Proceedings of 16th International Congress on Acoustics. Vol.4. 2505-2506 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.HOSOKAWA, T.OTANI: "Acoustical anisotropy in bovine cancellous bone" Journal of the Acoustical Society of America. Vol.103 No.5,Pt.1. 2718-2722 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 久保恭臣、吉野、高井、平澤、細川、大谷: "超音波の骨密度測定への応用に関する実験的研究-牛海綿骨の超音波の伝搬について-" 日本臨床バイオメカニクス学会誌. Vol19. 307-310 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.KUBO, S.TAKAI, N.YOSHINO, A.KOSOKAWA, T.OTANI: "Ultrasonic wave propagation in bovine trabecular bone" Transactions of the 3rd Combined Meeting of the Orthopaedic Research Societies of USA,Japan,and Europ.224 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 須崎 琢而: "超音波による海線骨特性の測定" READOUT (HORIBA Technical Reports). No.16. 25-28 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 五條雅史、今泉、大谷、須崎、高井: "ヒトの橈骨の音波伝搬特性に関する研究" 日本音響学会講演論文集. 9月. 1153-1154 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 椋田恭輔、大谷、須崎: "海綿骨中の音波伝搬-伝搬に伴う波形とスペクトルの変化-" 日本音響学会講演論文集. 3月. 851-852 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] HOSOKAWA, OTANI, SUZAKI, KUBO, TAKAI: "Influence of Trabecular Structure on Ultrasonic Wave Propagation in Bovine Cancellous Bone" Japanese Journal of Applied Physics. Vol.36,No.1-5B. 3233-3237 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] HOSOKAWA, OTANI, SUZAKI, KUBO, TAKAI: "Influence of Trabecular Structure in Bone on Ultrasonic Wave Propagation" Proceedings of Ultrasonics World Congress(YOKOHAMA). 368-369 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 久保、高井、平澤、細川、大谷: "海綿骨中の音響伝搬について" 日本整形外科学会誌. Vol71,No8. 1540 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] CAMUS, MUKUDA, OTANI, WATANABE: "Influence of fluid viscosity on the propagation of Ultrasonic waves in bovine cancellous bone" Technical Report of the Institute of Electronics,Information and Communication Engineers. US97-85. 1-8 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 久保、高井、平澤、細川、大谷: "牛海綿骨中の音波伝搬について" 第24回日本臨床バイオメカニクス学会論文抄録. 72 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 細川、大谷、須崎: "海綿骨中の音響伝搬-低速波の生成における表面状態の影響-" 日本音響学会平成9年度秋季研究発表会講演論文集. 巻2. 1129-1130 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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