| Project/Area Number |
09610093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
実験系心理学
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| Research Institution | Tokyo Metropol. Org. for Med Res., Tokyo Metropol. Inst. for Neurosci. (1999-2000)
Tokyo Metropolitan Institute for Neuroscience (1997-1998) |
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Principal Investigator |
YUKIE Masao Tokyo Metropolitan Institute for Neuroscience, Dept. Behav. Physiol., Research Scientist, 東京都神経科学総合研究所・認知行動研究部門, 主事研究員 (20113491)
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| Project Period (FY) |
1997 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2000: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Entorhinal cortex / Japanese monkey / Delayed matching to location / Delayed matching to color / Transverse patterning problem / Delayed matching to photographic stimuli with 2 foils / spatial memory / object recognition memory / 遅延見本合わせ / 写真刺激 / 3刺激比較 / 15分遅延 / 側頭葉内側部 / サル / 色の遅延見本合わせ課題 / 場所の遅延見本合わせ課題 / 嗅周皮質 / 視対象認知記憶 / WGA-HRP / BDA / 蛍光色素 |
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| Research Abstract |
1 : Connections of the entorhinal cortex (EC) with the hippocampal formation (HF) were examined using retrograde and anterograde treats in Japanese monkeys. The EC had heavy projection fibers to the dentate gyrus (DG) and CA1-CA3 fields. Those in the DG and CA1-CA3 fields were distributed in the molecular layer. Main inputs from the HF to the EC were originated from the pyramidal layer of the subiculum (Sub) and CA1 field. The CA1 field was superior to the Sub in the number of projection cells. All these projections were topographically organized ; the medial part of the EC was connected with the rostral portion of the HF (the DG, CA1-CA3 fields and Sub), while the lateral part of the EC was with the caudal portion. These results suggest that the EC had two main outputs to the HF (to the DG and CA1 field) and two main inputs from the HF (from the CA1 field and Sub). 2 : Effects of bilateral EC lesions in Japanese monkeys were examined on delayed matching to location (DML), to color (DMC), and to photographic stimuli (DMP) with 2 foils, and transverse patterning problem (TPP). For DML a mild impairment was produced only in relearning, while no impairment was seen in delay test (20, 30 and 40 sec. delays). For DMC, no deficit was seen on relearning or delay test (30, 60 and 120 sec. delays). For DMP, a mild impairment was produced in long-term delay (15 min.) of delay test alone, while no impairment was seen in relearning or short-term delay conditions (30, 60 and 120 sec. delays). In TPP, the EC monkeys learned as quickly as the controls. These results suggest that the EC might be involved at least in retention of spatial learning and recognition of stimuli with longer delay (15 min.).
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