| Project/Area Number |
09640637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Hiroshima International University (1998)
Hiroshima University (1997) |
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Principal Investigator |
USUI Shuji Department of Health Sciences, Hiroshima International University Professor, 保健医療学部, 教授 (20160252)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1997: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | metal coordination / hydrogen bonding / functionalized host / molecular recognition / amino acid / salen complex / association / chiral recognition / サレンニッゲル錯体 |
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| Research Abstract |
To understand the mechanism of molecular recognition in enzymes, artificial host molecules having both metal coordination and hydrogen bonding sites were synthesized.
(1) Binding study of salen-metal complexes having naphthol ring with amino acid derivatives.
From the NMR titration experiments, it was found that the nickel complex weakly binds with histidine dimethyl ester and the imidazole ring is played a important role in this binding. The cobalt complex is interacted with phenylalanine methyl ester by the fact of the UV spectral changes. The association constant and the host-guest structures are now under investigation.
(2) Binding study of salen-metal complexes having phenol rings with amines.
The nickel complex was found to interact with mono- and diamines by the 1 : 2 and 1 : 1 host-guest ratios, respectively. The binding constants obtained by the NMR titration studies were ca. 10^3-10^4 M^<-1>. Since 2, 7- diaminofluorene shows the largest association constant, both the metal and the central phenol are presumed to be the binding sites. Furthermore the salen manganese complex was shown to have a catalytic activity of olefin epoxidation.
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