THE ROLE OF INTERLAMELLAR WATER MOLECULES IN A FORMATION OF UNILAMELLAR FOR PHOSPHATIDYLGLYCEROL
| Project/Area Number |
09640702
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
機能・物性・材料
|
|---|
| Research Institution | OKAYAMA UNIVERSITY OF SCIENCE |
|---|
Principal Investigator |
KODAMA Michiko OKAYAMA UNIV.OF SCIENCE,DEPARTMENT OF SCIENCE,PROFESSOR, 理学部, 教授 (40101282)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AOKI Hiroyuki OKAYAMA UNIV.OF SCIENCE,DEPARTMENT OF SCIENCE,ASSOCIATED FROFESSOR, 理学部, 講師 (80248202)
|
|---|
| Project Period (FY) |
1997 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥3,000,000 (Direct Cost: ¥3,000,000)
|
|---|
| Keywords | differential scanning calorimetry / Phosphatidylglycerol(PG) / Interlamellar water / Ice-melting DSC curve / Na^<23>-nmα測定 / 示券走査熱量測定 / ファスファチジルグリセロール / 水融解エンタルピー / Na^<23>-nmr測定 / 示差走査熱量測定 / ジミリィストィールフォスファチジルグリセロール / 示差走査熱量測定(DSC) / ネガティブ染色電子顕微鏡観察 / ^<23>Na-NMR(核磁気共鳴) / ベシクル |
|---|
| Research Abstract |
Variation of the thermotropic behavior of both lipid assemblies and associated water molecules with an increase in water content was investigated for negatively charged phosphatidyiglycerol (PG)-water system up to 95 wt.% water by differential scanning calorimetry (DSC). The number of water molecules interposed into interbilayer regions of the present system was estimated from a deconvolution analysis of ice-melting DSC curves On the basis of a result of the calorimetric method, a water distribution diagram was constructed over the water content range from 0 to 95 wt.% water. The diagram revealed a continuous incorporation of freezable interlamellar water up to 95 wt.%, in contrast with a limiting incorporation for neutral lipids such as phosphatidyicholine (PC) and phosphatidylethanolamine (PE). Such a characteristic interlamellar water uptake for PG was discussed from the viwpoint of unilamellar forming property for this lipid.
|
Report
(3 results)
Research Products
(19 results)
