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Development of munti-functional and dimensional HPLC stationary phases using molecular imprinting.

Research Project

Project/Area Number 09640726
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 分離・精製・検出法
Research InstitutionKyoto Institute of Technology

Principal Investigator

HOSOYA Ken  Kyoto Inst.of Tech., Dept.of Polym.Sci., Associate Prof., 繊維学部, 助教授 (00209248)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsMolecular imprinting / HPLC / Uniform size beads / Molecular recognition / Multi-dimensional / Surface modification
Research Abstract

For the development of multi-dimensional stationary phases, I studied molecular imprinting technique and selective surface modification method. On the basis of the above results, the objective stationary phases can be prepared a simple combination of molecular imprinting technique and surface modification method.
For the further study, I prepared a variety of molecularly imprinted stationary phases and studied porous structures from the viewpoints of chemistry as well as liquid chromatog-raphy. In addition, I applied novel temperature-responsive external layer or hydrophulic ex-eternal layer for separation of the target moiety from complicated mixtures.
Finally, I obtained the following results.
1. Porogen imprinting effects was firstly reported. Porogen imprinting realized molecular recognition towards structurally similar compounds.
2. Porogen imprinting also afforded preferential retention towards more toxic compounds such as coplanar PCBs.
3. Direct injection and analysis were realized using molecularly imprinted stationary phases selectively modified with hydrophilic external layer.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] 細矢 憲: "Polymeric chiral surface functionality immobilized on uniformly sized macroporous polymer beads." J.Polym.Sci.Part A : Polym.Chem.35. 2747-2757 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 細矢 憲: "Direct chromatographic separation of racemates on the basis of isotopic chirality." Anal.Chem.69. 2610-2612 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 細矢 憲: "Porogen imprinting effects" Anal.Chem.70. 386-389 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 細矢 憲: "Molecularly imprinted chiral stationary phase prepared with racemic template." Anal.Chem.70. 934-945 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 細矢 憲: "Molecular recognition towards coplanar polychlorinated biphenyls based on the porogen imprinting effects of xylenes." J.Chromatogr.A. 828. 91-94 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 細矢 憲: "Uniform-sized molecularly imprinted polymer for(S)-naproxen selectively modified with hydrophilic external layer." J.Chromatogr.A. (印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 細矢 憲: "Chromatographic separations based on molecular recognition" Wiley-VCH, 425 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 細矢 憲: "Molecular and Ionic Recognition with Imprinted Polymers" American Chemical Society, 338 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ken Hosoya: "Polymeric chiral surface functionality immobilized on uniformly sized macroporous polymer beads." J.Polym.Sci.Part A : Polym.Chem. 35. 2747-2757 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ken Hosoya: "Direct chromatographic separation of racemates on the basis of isotopic chirality" Anal.Chem.69. 2610-2612 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ken Hosoya: "Porogen imprinting effects" Anal.Chem.70. 386-389 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ken Hosoya: "Molecularly imprinted chiral stationary phase prepared with recemic template" Anal.Chem. 70. 934-945 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ken Hosoya: "Molecular recognition towards coplanar plychlori-nated biphenyls based on the porogen imprinting ef-fects of xylenes" J.Chromatogr.A. 828. 91-94 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ken Hosoya: "Uniform-sized molecularly imprinted polymer for (S)-naproxen selectively modified with hydrophilic exter-nal layer." J.Chromatogr.A. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ken Hosoya: Chromatographic separations based on molecular rec-ognition. Wiley-VCH, 425 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ken Hosoya: Molecular and Ionic Recognition with Imprinted Polymers. American Chemical Society, 338 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 細矢 憲: "Polymeric chiral surface functionality immobilized on uniformly sized macroporous polymer beads." J.Polym.Sci.Part A:Polym.Chem.35. 2747-2757 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 細矢 憲: "Direct chromatographic separation of racemates on the basis of isotopic chirality." Anal.Chem.69. 2610-2612 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 細矢 憲: "Porogen imprinting effects" Anal.Chem.70. 386-389 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 細矢 憲: "Molecularly imprinted chiral stationary phase prepared with racemic template." Anal.Chem.70. 934-945 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 細矢 憲: "Molecular recognition towards coplanar polychlorinated biphenyls based on the porogen imprinting effects of xylenes." J.Chromatogr.A. 828. 91-94 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 細矢 憲: "Uniform-sized molecularly imprinted polymer for(S)-naproxen selectively modified with hydrophilic external layer." J.Chromatogr.A. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 細矢 憲: "Chromatographic separations based on molecular recognition" Wiley-VCH, 425 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 細矢 憲: "Molecular and Ionic Recognition with Imprinted Polymers" American Chemical Society, 338 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 細矢 憲: "Polymeric chiral surface functionality immobilized on uniformly sized macroporous polymer bead" J.Polym.Sci.Part A:Polym.Chem.35. 2747-2757 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 細矢 憲: "A short and efficient synthetic process to enantiomerically pure (+)-Syributin1" Heterocycles. 45. 1903-1906 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 細矢 憲: "Formal synthesis of (-)-Syrinbolide 1 staring from D-xylose based on a biomimetic strategy." Heterocycles. 45. 1895-1898 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 細矢 憲: "Direct chromatographic separation of racemates on the basis of isotopic chirality." Anal.Chem. 69. 2610-2612 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 細矢 憲: "Porogen imprinting effects" Anal.Chem. 70. 386-389 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 細矢 憲: "Molecularly imprinted chiral stationary phase prepared with racemic template." Anal.Chem. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 細矢 憲: "Molecular and Ionic Recognition with Imprinted Polymers" American Chemical Society (印刷中), (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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