| Project/Area Number |
09640733
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
分離・精製・検出法
|
|---|
| Research Institution | Himeji Institute of Technology |
|---|
Principal Investigator |
OTSUKA Koji Himeji Institute of Technology, Faculty of Science, Assoiciate Professor, 理学部, 助教授 (70183762)
|
|---|
| Project Period (FY) |
1997 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥2,600,000 (Direct Cost: ¥2,600,000)
|
|---|
| Keywords | non-aqueous / capillary electrophoresis / environmental science / organic solvents / cyclodextrins / chiral separation / dioxins / herbicides / 非水系溶液 / MEKC / CE |
|---|
| Research Abstract |
Analysis of environmental-interest analytes or environmental pollutants by capillary electro phoresis (CE) using non-aqueous solutions was investigated. Chiral separations by non-aqueous CE, effects of compositions of cyclodextrin (CD) derivatives in chiral separations by aqueous CE, stereoselective separation and detection of herbicides enantiomers by on-line CE - mass spectrometry (MS), chiral separations by micellar electrokinetic chromatography (MEKC) using novel chiral surfactants, and high sensitive analysis of dioxins and related compounds by MEKC with on-line concentration were studied.
1. Dimethylformamide, dimethylsulfoxide (DMSO), acetone, and tetrahydrofuran (THF) were found to be effective solvents for non-aqueous CE.
2. Chiral separations of herbicide enantiomers and dansyl-DL-amino acids were achieved by non-aqueous CE using a beta-CD/DMSO or beta-CD/formamide solution.
3. Chiral separations of drug component enantiomers were achieved by non-aqueous CE using an OD-R polymer/acetone or OD-R polymer/THF solution. (OD-R polymer is a chiral polymer.)
4. Effects of compositions of commercial dimethyl-beta-CDs on chiral recognitions in CD modified capillary zone electrophoresis were investigated.
5. Chiral separation and detection of phenoxy acid herbicide enantiomers by CE-MS using beta-CD derivatives was successfully achieved.
6. Some drug component enantiomers and DL-amino acid derivatives were optically resolved by MEKC using novel chiral surfactants.
7. High sensitive analysis of dioxin related compounds were carried out by CD modified MEKC using an on-line concentration technique.
8. By using capillary electrochromatography with chiral stationary phases, chiral separations of some drug components were achieved.
|
