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DEVELOPMENT OF IN-SITSU MEMBRANE SEPARATION PROCESS FOR ORGANIC ACID FERMENTATION

Research Project

Project/Area Number 09650851
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 反応・分離工学
Research InstitutionDOSHISHA UNIVERSITY

Principal Investigator

KONDO Kazuo (1999)  Doshisha University, Faculty of Engineering, Professor, 工学部, 教授 (30038096)

松本 道明 (1997-1998)  同志社大学, 工学部, 助教授 (10157381)

Co-Investigator(Kenkyū-buntansha) 近藤 和生  同志社大学, 工学部, 教授 (30038096)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsLactic Acid / Fermentation of Organic Acid / Cellulose Triacetate / Synergism / Microcapsule / 担体輸送
Research Abstract

The aim of this research is to develop in situ membrane separation process for the fermentation of organic acid. Preparation of optically active lactic acid using fermentation has attracted much attention because the production of biodegarable poly(lactic acid) is commercialized. To reduce the level of end-product inhibition in the fermentation, many processes involving procedures to separate the products have been developed. Among the processes, solvent extraction with chemical reaction is promising from economical reason. Two critical problems in the lactic acid fermentation combined with the reactive extraction remains to be resolved. The first is the toxicity of organic solvents to microbes. To avoid the direct contact between the microbes and organic solvent, we prepared the extractant impregnated cellulose triacetate membrane or polystyrene-supported microcapsules. The permeation rate of lactic acid through the membrane was relatively fast, but the extractant leaked from the membrane or capsules and fermentation stopped because of the strong toxicity of the trace amount of extractant dissolved in the broth. The second problem is the difference in the optimum pH between fermentation and reactive extractions using less toxic extractants. To overcome this point, we developed the new synergistic extraction system of lactic acid using tri-n-octylamine and tri-n-butyphosphate. But mixed extractants could not applied to the membrane separation system was problem because cellulose triacetate was hydrolyzed by the alkaline solution used as a stripping reagent. We tried to prepare the microcapsules involving the mixed extractants. The attempt was successful and its possible to apply the microcapsules to the fermentation of lactic acid.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] M. Matsumoto: "Permeation of Lactic Acid Through Polymeric Membrane"Proc. the 4^<th> Sino-Japanese Symposium on Liquid Membranes. 115-118 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Matsumoto: "Separation of Lactic Acid using Polymeric Membrane Containing a Mobile Carrier"J. Ferment. Bioeng.. 85. 438-487 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Matsumoto: "Synergistic Extraction of Lactic Acid with Tri-n-octylamine and Tri-n-butylphosphate"J. Chem. Eng. Japan. 31. 996-998 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Matsumoto: "Fermentation of Lactic Acid Combined with Solvent Extraction or Membrane Separation Containing a Mobile Carrier"Recent Res. Develop. Ferment. Bioeng.. 1. 241-252 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Matsumoto: "Synergistic Extraction of Organic Acids with Tri-n-butylphosphate and Tri-n-octylamine"Proc. the 3^<rd> Taipei-Kyushu Joint Symposium on Chemical Engineering. 93-95 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Matsumoto: "Extraction Equilibria of Organic Acids with Tri-n-octylmethyl Ammonium Chloride"Solv. Extr. Res. Develop., Japan. 6. 144-150 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Michiaki Matsumoto, Seiji Yuba and Kazuo Knodo: "Permeation of Lactic Acid thorough Polymeric Membrane"Proc. 4th Sino-Japanese Symposium on Liquid Membranes. 115-118 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Michiaki Matsumoto, Toshiyuki Takagi and Kazuo Kondo: "Separation of Lactic Acid using Polymeric Membrane Containing a Mobile Carrier"J. Ferment. Bioeng.. 85(5). 483-487 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Michiaki Matsumoto, Seiji Yuba and Kazuo Kondo: "Synergistic Extraction of Lactic Acid with Tri-n-Octylamine and Tri-n-Butylphosphate"J.Chem.Eng.Japan. 31(6). 996-998 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Michiaki Matsumoto and Kazuo Knodo: "Fermentation of Lactic Acid Combined with Solvent Extraction of Membrane Separation Containing a Mobile Carrie"Recent Res. Develop.Ferment. Bioeng.. 1. 241-252 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Michiaki Matsumoto and Kazuo Kondo: "Synergistic Extraction of Organic Acids with Tri-n-Butyl phosphate and Tri-n-Octylamine"Proc. 3rd Taipei-Kyushu Joint Symposium on Chemical Engineering. 93-95 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Michiaki Matsumoto, Toshiyuki Takagi, Tsutomu Nakaso and Kazuo Knodo: "Extraction Equilibria of Organic Acids with Tri-n-Octylmethylammonium Chloride"Solv. Extr. Res. Develop. Japan. 6. 144-150 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 近藤和生: "Fermentation of Lactic Acid Combined with Solvent Extraction of Membrane Separation Containing a Mobile Carrier"Recent Research DeveCopments in Fermentation& Bioengineering. 1. 241-252 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 近藤和生: "Synergisfic Extraction of Organic Acids with Tri-n- Butulphoshate and Tri-n-Octylamine"Proc,of the 3rd Taipei-Kyushu Joint Syinp.on Chemical Engineering. 93-95 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 近藤和生: "Extraction Equilibria of Organic Acids with Tri-n-Octylmethylammonium Chloride"Solvent Extraction Research and Development,Japan. 6. 144-150 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松本 道明: "Permeation of Lactic Acid through Polymeric Membrane Containing Mobile Carriers" Proceedings of the 4th Sino-Japanese Liquid Membrane Symposium. 115-118 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松本 道明: "Separation of Lactic Acid Using Polymeric Membrane Contaning a Mobile Carrier" Journal of Fermentation and Bioengineering. 85・5. 484-488 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松本 道明: "Synergistic Extraction of Lactic Acid with Tri-n-octylamine and Tri-n-butylphosphate" Journal of Chemical Engineering of Japan. 31・6. 996-998 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松本 道明: "Fermentation of Lactic Acid Combined with Solvent Extraction or Membrane Separation Containing a Mobile Carrier" Recent Research Developments in Fermentation and Bioengineering. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 松本 道明: "Synergistic Extraction of Organic with Tri-n-butylphosphate and Tri-n-octylamine" Proceedings of 3^<rd> Taipei-Kyushu Joint Symposium on Chemical Engineering. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Michiaki Matsumoto: "Permeation of Lactic Acid through Polymeric Membrane Containing Mobile Carriers" 第四回日中液膜シンポジウム. (発表予定).

    • Related Report
      1997 Annual Research Report
  • [Publications] Michiaki Matsumoto: "Permeation of Lactic Acid through Polymeric Membrane Containg a Mobile Carrier" Journal of Fermentation and Bioengneering. (掲載決定).

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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