| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Research Abstract |
Preventive effects of nasunin, an anthocyanin in eggplant, and of anthocyanins in atsumi-kabu (a species of red turnip) and blueberries were examined in paraquat-induced oxidative stress rats.
Nasunin showed strong antioxidative effect in vivo, and protected decreases in food intake , body weight gain, liver triacyiglycerol level and catalase activity in mitochondrial fraction, and increases in lung weight, and NADPH-cytochrome P-450 reductase activity which were induced by administering paraquat to rats. It was suggested from these results that nasunin is effective to protect oxidative stress in vivo. On the other hand, although anthocyanins in atsumi-kabu and blueberries also showed tendencies to suppress decreases in food intake, body weight gain, decrease in catalase activity in liver mitochondrial fraction, and increase in lung weight, their preventive effects for oxidative stress were weak than those of nasunin. Superoxide anion scavenging activity of nasunin in vitro was stonger than that of anthocyanins of atsumi-kabu and blueberries, suggesting that strong antioxidative activity of nasunin in vivo partly is due to radical scavenging activity of nasunin in vivo. inhibition of NADPH-cytochrome P-450 reductase activity which increase in administration of paraquat, by feeding anthocyanins suggested that generation of active oxygen species may be suppressed in rats fed on anthocyanins, resulting in relieve of oxidative stress by paraquat.
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