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Influence of oral tolerance of food antigens on systemic humoral immune response against vaccinal antigen

Research Project

Project/Area Number 09660320
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionKobe University (1999)
Tottori University (1997-1998)

Principal Investigator

KITAGAWA Hiroshi  Kobe University, Graduate School of Science and Technology, Professor, 大学院・自然科学研究科, 教授 (40125307)

Co-Investigator(Kenkyū-buntansha) 今川 智敬  鳥取大学, 農学部, 助手 (20232605)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordschicken / alimentary tract / oral tolerance / bystander suppression / 免疫 / ワクチン
Research Abstract

Oral tolerance have little clarified in birds. Influence of animal proteins in formula on specific immune responses to vaccinal antigens have never reported. Effects of animal proteins involved in vaccines on the immune response to vaccinal antigen have also never investigated in chickens.
This research aims at clarifing 1.whether the tolerance of orally induced animal protein antigen (APA) is established or not in the systemic humoral immune response to the APA, 2.whether the bystander suppression of orally induced APA is established or not in the systemic humoral immune response to the different special antigen (DSA), and 3.whether the bystander suppression of APA is established or not in animals already raised systemic humoral immune response against APA.
As a result, the oral tolerance of APA was induced after long term oral administration of APA. The systemic humoral immune response against APA was slightly reduced in the tolerance-induced chickens. The bystander suppression was also established in systemic humoral immune response to DSA after intravenous induction of both APA and dAPA. In animals already raised systemic humoral immune response to DSA, however, the bystander suppression was not found after intravenous induction of both APA and DSA. The systemic humoral immune response was enhanced.
On the completion of these experiments, the results obtained in these researches will be immediately published. Further investigations on the regulation of intestinal flora and the more effective vaccination by means of the oral tolerance or the bystander suppression are proceeding.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Takashi Takeuchi: "Apoptosis of villous epithelial cells and follicle-associated epithelial cells in chicken cecum"J. Vet. Med. Sci.. 61. 149-154 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tomohiro Imagawa: "Quantitative studies of the optic nerve layer in chicken retina"J. Vet. Med. Sci.. 61. 883-889 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Etsumori Harada: "Characteristic transport of lactoferin from the intestinal lumen into the bile bia the blood in piglets"Comp. Biochem. Physiol.. 124. 321-327 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takashi Takeuchi: "Proliferation and cellular kinetics of villous epithelial cells and M-cells in the chicken caecum"J. Anat.. 193. 233-239 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroshi Kitagawa: "Distribution of lymphoid tissue in the caecal mucosa of chicken"J. Anat.. 192. 293-298 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masato Uehara: "Quantitative studies of nuclear bodies in astrocytes of chicken spinal cord following axonotomy"J. Vet. Med. Sci.. 60. 773-775 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tetsuo Matsuura: "Developmental study on reduction and kinks of the tail in a new mutant knotty-tail mouse"Anat. Embryol.. 198. 91-99 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tetsuo Matsuura: "Morphology and morphometry of the deformed cervical vertebrae in the mutant Knotty-tail (knt/knt) mouse"Cong. Anom.. 38. 67-79 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tomohiro Imagawa: "An Association between rodlet cells and the vascular endothelial cells in the cells and the vascular endothelial cells in the head kidney of carp, Cyprinus caprioL"J. Fish Dis.. 21. 153-157 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahiro Kanno: "Simplified preparation of a refined milk formular comparable to rat milk"J. Pediatr. Gastroenterol. Nutr.. 24. 242-252 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tetsuo Matsuura: "Morphological and morphometric features of the deformed cervical and caudal vertebrae in a new mutant knotty-tail …"Ann Anat.. 179. 277-283 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takashi Takeuchi et al.: "Apoptosis of villous epithelial cells and follicle-associated epithelial cells in chicken cecum"J. Vet. Med. Sci.. 61-1. 149-154 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tomohiro Imagawa et al.: "Quantitative studies of the optic nerve layer in chicken retina"J. Vet. Med. Sci.. 61-1. 883-889 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Etsumori Harada et al.: "Characteristic transport of lactoferin from the intestinal lumen into the bile bia the blood in piglets"Comp. Biochem. Physiol.. 124-3. 321-327 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takashi Takeuchi et al.: "Proliferation and cellular kinetics of villous epithelial cells and M-cells in the chicken caecum"J. Anat.. 193-2. 233-239 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroshi Kitagawa et al.: "Distribution of lymphoid tissue in the caecal mucosa of chicken"J. Anat.. 192-2. 293-298 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masato Uehara et al.: "Quantitative studies of nuclear bodies in astrocytes of chicken spinal cord following axonotomv"J. Vet. Med. Sci.. 60-6. 773-775 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tetsuo Matuura et al.: "Development study on reduction and kinks of the tail in a new mutant knottv-tail mouse"Anat. Embryol.. 198-1. 91-99 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tetsuo Matuura et al.: "Morphology and morphometry of the deformed cervical vertebrae in the mutant Knottv-tail (knt/knt) mouse"Cong. Anom.. 38-1. 67-79 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tomohiro Imagawa et al.: "An association between rodlet cells and the vascular endothelial cells in the head kidnev of carp. Cyprinus carpioL"J. Fish Dis.. 21-2. 153-157 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahiro Kanno et al.: "Simplified preparation of a refined milk formular comparable to rat milk"J. Pediatr. Gastroenterol. Nutr.. 24-3. 242-252 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tetsuo Matuura et al.: "Morphological and morphometric features of the deformed cervical and caudal vertebrae in a new mutant knottv-tail"Ann. Anat.. 179-3. 277-283 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takashi Takeuchi: "Apoptosis of villous epithelial cells and follicle-associated epithelial cells in chicken cecum"J.Vet.Med.Sci.. 149-154 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tomohiro Imagawa: "Quantitative studies of the optic nerve layer in chicken retina"J.Vet.Med.Sci.. 883-889 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Etsumori Harada: "Characteristic transport of lactoferin from the intestinal lumen into the bile bia the blood in piglets"Comp.Biochem.Physiol.. 321-327 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takashi Takeuchi: "Apoptosis of villous epithelial cells and follicle-associated epithelial cells in chicken cecum." Journal of Veterinary Medical Science. 61. 149-154 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takashi Takeuchi: "Proliferation and cellular kinetics of villous epithelial cells and M cells in the chicken caecum." Journal of Anatomy. 193. 233-239 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiroshi Kitagawa: "Distribution of lymphoid tissue in the caecal mucosa of chickens." Journal of Anatomy. 192. 293-298 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masato Uehara: "Quantitative studies of nuclear bodies in astrocytes of chicken spinal cord following axonotomy." Journal of Veterinary Medical Science. 60. 773-775 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tetsuo Matuura: "Developmental study on reduction and kinks of the tail a new mutant knotty-tail mouse." Anatomy and Embryology. 198. 91-99 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tetsuo Matuura: "Morphology and morphometry of the deformed vervical certebrae in the mutant Knotty-tail (knt/knt) mouse." Congenital Anomalies. 38. 67-79 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiroshi Kitagawa: "Distribution of lymphoid tissue in the caecal mucosa of chickens." Journal of Anatomy. 192(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tomohiro Imagawa: "An association between rodlet cells and the vascular endothelial cells in the head kidney of carp,Cyprinus carpio L : ultrastructural observation." Journal of Fish Diseases. 21(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takahiro kanno: "Simplified prepation of a refined milk formura comparable to rat milk : Influence of the formula on development of the gut and brain in artificially reard rat pups." Journal of Pediatric Gastroenterology and Nutrition. 24. 242-252 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tetsuro Matsuura: "Morphological and morphometric features of the deformed cervical and caudal vertebrae in a new mutant knotty-tail(knt/knt)mouse." Annals of Anatomy. 179. 277-283 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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