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CELL PROLIFERRATION AND PROGRAMED CELL DEATH FOR MORPHOMETRIC POSITIONING OF STRUCTURAL PATTERN AND DEVELOPMENTAL GROWTH DERECTION IN EPITHELIAL-MESENCHYMAL MORPHOGENESIS.

Research Project

Project/Area Number 09660330
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionNIPPON VETERINARY AND ANIMAL SCIENCE UNIVERSITY

Principal Investigator

AMASAKI Hajime  NIPPON VETERINARY AND ANIMAL SCIENCE UNIVERSITY,DEPERTMENT OF VETERINARY AND ANIMAL SCIENCE, 獣医畜産学部, 助教授 (50147865)

Co-Investigator(Kenkyū-buntansha) SUZUKI Hiroetsu  NIPPON VETERINARY AND ANIMAL SCIENCE UNIVERSITY,DEPERTMENT OF VETERINARY AND ANIMAL SCIENCE,ASSISTANT, 獣医畜産学部, 助手 (50277662)
SUZUKI Katsushi  NIPPON VETERINARY AND ANIMAL SCIENCE UNIVERSITY,DEPERTMENT OF VETERINARY AND ANIMAL SCIENCE,PROFESSOR, 獣医畜産学部, 教授 (00125080)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsOrganogenesis / Interaction / Proliferation / Apoptosis / Arrangement / Positioning
Research Abstract

Present research was produced to reveal the mechamism of regularly patterned structure of the organ and the topological consorted growing orientations with organic specific differentiations in the epithelial-mesenchymal composed organ. We used the developmental murian and cow's palatine ridge systems and also the developmental cow's ruminal papillary system for an investigation of structural patterns of analysis, and the murian intestinal system for the functional diffrentiation of analysis under the cell cycle controls. While, control mechanisms of some specific gene expresssions and the cell cycle systems for the morphogenesis in above digestive organs were recomfirmed to be affected with the consorted expressions of many extra-cellular matrices, those of cell adhesion mollecules, those of integlins at the interface between the epithelial cell and the subepithelial mesenchyme, and also those of intracelluar micro-fibriles (J. Vet. Med. Sci., 1997, 1999). The cell cycle was known to be controled by the cell proliferation and the programed cell death. Present developmental systems in vivo strongly suggested to the primary intiations of structural position and growing orientations with specific functional diffrentiations would be also affected with the cell cycle systems (Immunology, 1999, in preparation for submission). Additionaly, methods for the organ-culture system of present research and for the detection with some mRNAs in cell system and cell differentiations would be masterd under present accumplised research.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Masamine TAKANOBU, et al.: "Identification of bovine decorin in the fetal bovine rumen"Journal of Veterinary Medical Science. 59(2). 121-123 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] AMASAKI H, TAKANOSU M. and MAWATARI T.: "Distribution of Cytokeratin Polypeptides Detected by Monoclonal Antibodies K8.13 and 8.12 in the fetal bovine ruminal epithelium"Journal of Veterinary Medical Science. 61(3). 261-265 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.MATSUMOTO, et al.: "Physiological roles of gannnma-delta T-cell receptor intraepithelial lymphocytes in cytoproliferation and differentation of mouse intestinal epithelial cells"Immunology. 96. 18-25 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masamine TAKANOSU, et al.: "Identification of bovine decorin in the fetal bovine rumen."Journal of Veterinary Medical Science. 59 (2). 121-123 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] ANASAKI H., TAKANOSU M. and MAWATARI T.: "Distribution of Cytokeratin Polypeptides Detected by Monoclonal Antibodies K8.13 and 8.12 in the fetal bovine ruminal epithelium."Journal of Veterinary Medical Science. 61 (3). 261-265 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S. MATSUMOTO, et al.: "Physiological roles of gannma-delta T-cell receptor intraepithelial lymphocytes in cytoproliferation and differentation of mouse intestinal epithelial cells."Immunology. 96. 18-25 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.MATSUMOTO. et al.: "Physiological roles of gamma delta T cell receptor intraepithelial lymphocytes in cytoproliferation and differentiation of mouse intestinal epithelial cell"Immunology. 96. 18-25 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] AMASAKI H.,TAKANOSU M.and MAWATARI T.: "Distribution of Cytokeratin Polypeptides Detected by Monoclonal Antibodies K8.13 and 8.12 in the fetal bovine ruminal epithelium." Journal of Veterinary Medical Science. 61(3). 261-265 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] TAKANOSU M.,AMASAKI H.and SUZUKI K.: "Cell proliferation and apoptosis in developing murine palatine ridge." Acta Anatomica. (発表予定).

    • Related Report
      1998 Annual Research Report
  • [Publications] TAKANOSU M., H.AMASAKI, H.MIURA, M.ASARI and K.SUZUKI: "Identification of bovine decorin in the fetal bovine rumen." Journal of Veterinary Medical Science. 59(2). 121-123 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Amasaki., Takanosu,M and K.Suzuki: "Changes of cell ploliferation and Apoptosis in murine platine ridge formation." Acta Anatomica. (発表予定).

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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