| Project/Area Number |
09660332
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Basic veterinary science/Basic zootechnical science
|
|---|
| Research Institution | Azabu University School of Veterinary Medicine |
|---|
Principal Investigator |
WAKUI Shin Azabu University, 獣医学部, 助教授 (40201157)
|
|---|
| Project Period (FY) |
1997 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥2,200,000 (Direct Cost: ¥2,200,000)
|
|---|
| Keywords | Angiogenesis / Endothleial cell-pericyte interdigitation / VEGF |
|---|
| Research Abstract |
In the present study, I have investigated the ultrastructural localization of TGFb, plasminogen activator(PA) and pasminogen(Pn) in granulation tissue. Angiogenesis is a prominent feature of granulation tissue and is largely composed of an abundance of immature capillaries. A number of endothleial cell-pericyte interdigitation(EPI) are observed in immature capillaries in granulation tissue. In this study, TGFb, PA, and Pn immunoreactivities were colocalized selectively at a large number of the EPI in the newly formed capillaries. The present study opens several new directions for the study concerning angiogenesis in situ, especially the heterotypic cell-to-cell interaction(EPI) with angiogenic process.
|
