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Developmental plasticity in hypoxic ventllatory response

Research Project

Project/Area Number 09670038
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionChiba University

Principal Investigator

HAYASHI Fumiaki  Chiba Univ., Associate Professor, 医学部, 助教授 (80173029)

Co-Investigator(Kenkyū-buntansha) FUKUDA Yasuichiro  Chiba Univ., Professor, 医学部, 教授 (10009649)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1998: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsplasticity / development / hypoxic ventilatory response / hyperoxic denervation / perinatal period / rat / 低酸素による換気応答 / 神経回路 / 発達にともなう可塑性 / 呼吸調節
Research Abstract

We hypothesized that neonatal deprivation of peripheral chemoreceptor inputs by perinatal hyperoxia (hyperoxic denervation) irreversibly impairs the hypoxic ventilatory response in adults rats. To test the hypothesis, the pregnant rats were put into chambers flushed continuously with 50-60 % oxygen or air (hyperoxic group, HOG ; normoxic group, CONT). Litters (n=10 for HOG and n=8 for CONT) were born two days after starting hyperoxic exposure, which then continued for 4 weeks. Eight to twelve weeks after hyperoxic exposure, animals were anesthetized with urethane (1 .2g/kg, i.p.). The arterial blood gas (Paco_2 and Pao_2), ventilatory parameters (VT, tidal volume ; f, respiratory frequency ; VE, minutes ventilation) and the ventilatory response to hypoxia (F_<IO2> = 0.40, 0.21, 0.15, 0.10) were measured. During breathing air, there were no significant differences in ventilatory parameters and Paco_2 or Pao_2 between both groups. However, the ventilatory response to hypoxia was attenuated by 45% in HOG as compared to CONT.
Our results indicated that the hyperoxic denervation by perinatal hyperoxia irreversibly impaired the hypoxic ventilatory responsiveness without any changes in the baseline ventilatory parameters and arterial blood gas values. Neonatal deprivation of peripheral chemoreceptor inputs by perinatal hyperoxia induced the developmental plasticity of the neuronal circuit involved in the hypoxic ventilatory response, and hence attenuated the ventilatory responsiveness to hypoxia.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Sugito K.et al.: "Role of carotid body in pressure response of pulmonary circulation in rats" Respiration Physiology. 111. 283-293 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshizaki H.et al.: "Effect of posture change on control of breathing" Japanese Journal of Physiology. 48. 267-273 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shiba K.et al.: "Multifunctional laryngeal motoneurons in cat : an intracellular study" Journal of Neuroscience. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taki J.et al.: "Increased cardiovascular and metabolic tolerance to acute hypoxia in the rat with increased hemoglobin-O_2 affinity induced by Na-cyanate treatment" Japaneses Journal of Physiology. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugito K.et al.: "Role of carotid body in pressure response of pulmonary circulation in rats" Respir Physiol. 111. 283-293 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshizaki H.et al.: "Effect of posture change on control of breathing" Jpn J Physiol. 48. 267-273 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shiba K.et al.: "Multifunctional laryngeal motoneurons in cat : an intracellualr study" J Neuroscience. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taki J.et al.: "Increased cardiovascular and metabolic tolerance to acute hypoxia in the rat with increased hemoglobin-O_2 affinity induced by Na-cyanate treatment" Jpn J Physiol. In press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugito K,et al.: "Role of carotid body in pressure response of puliuonary civculation in rats" Respiration Physiology. 111. 283-293 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshizaki H.,et al: "Effect of pasture change on cantrol of breathing" Japanese Journal of Physiology. 48. 267-273 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shiba K.,et al: "Multifunctional largigeal motoneurons in cat:an intracellular otudy" Journal of Neciroscience. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] McCrimmon DR etal: "Modulation of the synaptic thine to respiratory premotor and motor neurons." Respir physiol. 110. 161-176 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Aouda A.etal.: "Anivitre brainstem-spinalcord-heart preparation of the neonatal rat with intact vagus nerve." Jap.J.Physiol. 47. 256-266 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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