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Analyses of the inhibitory mechanism of agiogenesis by plasminogen fragment

Research Project

Project/Area Number 09670041
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionHAMAMATU UNIVERSITY SCHOOL OF MEDECINE

Principal Investigator

TAKADA Akikazu  Hamamatsu Univ. Sch. of Med., Dept. Physiology, Professor, 医学部, 教授 (80092980)

Co-Investigator(Kenkyū-buntansha) NAGAI Nobuo  Hamamatsu Univ. Sch. of Med., Dept. Physiology, Reseach Associate, 医学部, 助手 (90260281)
IHARA Hayato  Hamamatsu Univ. Sch. of Med., Dept. Physiology, Reseach Associate, 医学部, 助手 (00223298)
URANO Tetsumei  Hamamatsu Univ. Sch. of Med., Dept. Physiology, Associate Professor, 医学部, 助教授 (50193967)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsangiostatin / angiogenesis / tumor metastasis & invasion / plasminogen / 線溶
Research Abstract

(1) Recently much attention has been paid to angiogenesis, which appeared to play important roles in tumor growth and its metastasis as well as tissue repair and remodeling. Folkman et al reported that "angiostatin" , a fragment of plasminogen molecule (kringle 1-3), showed strong inhibitory activity toward angiogenesis. Since detailed mechanism for angiostatin to be generated and that to inhibit angiogenesis are not elucidated yet, we tried to identify angiostatin molecule in cancer tissue and to reveal its structural characteristics.
(2) We generated and purified "angiostatin (K1-3) " as an elastase digested fragment of human plasminogen. By this purified angiostatin, two monoclonal antibodies were developed. Both antibodies were shown to react with angiostatin but not with mini-plasminogen which lacks kringle 1-4. These also reacted with plasminogen molecule.
(3) In the conditioned medium of fibrosarcoma cell line of HT1080, generated angiostatin was detected by western immuno-blotting. A part of the intra-molecular di-sulfide bond was dissociated in this angiostatin and free-SH was detected. In the angiostatin obtained as an elastase-digested plasminogen fragment, free SH was not detected.
(4) In human colon cancer tissue, larger amounts of low molecular weight fragments of plasminogen were detected compared to normal colon tissue. A part of these plasminogen fragments showed that their intra-molecular disulfide bonds were dissociated.
These results suggest that certain amounts of angiostatin are generated in tumor tissue and may play roles in tumor growth and in metastasis. Since the mechanism to generate angiostatin in tumor tissue seems to be different from elastase digestion of plasminogen, further studies are required to elucidate the mechanism. The possible function and the importance of angiostatin in tumor expansion should be also analyzed.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (106 results)

All Other

All Publications (106 results)

  • [Publications] Takada, Y., et al.: "Effects of Nicotine on serotonergic systems of brain and blood of rats exposed to footshck"Biogenic Amines. 13(1). 67-78 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi, H., et al.: "Fibrinolytic parameters as an admission prognostic amrker of head injury in patients who talk and deteriorate"J. Neurosurgery. 86. 768-772 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakano, T., et al.: "Remnant-like particle stimulate platelet aggregation in whole blood. Atherosclerosis IV : Recent Advances in Atherosclerosis Research"Ann. N. Y. Acad, Sci.. 811. 480-487 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Urano, T., et al.: "Amounts of tPA and PAI-1 in the eugloblin fraction obtained at different pH : Their relation to the euglobulin clot lysis time"Thrombosis Research. 88(1). 75-80 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Rydzewski, A., et al.: "Diurnal variation in serum remnant-like lipoproteins, platelet aggregation and fibrinolysis in healthy volunteers"Haemostasis. 27. 305-314 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Malyszko, J., et al.: "DV-7028, a novel selective serotonin (5-HT)2 receptor antagonist, and ketanserin influence normal and urine platelet aggregation in vitro"J. Serotonin Res.. 4. 223-232 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeda, Y., et al.: "MCI-9042, the new selective antagonist of serotonergic (5HT2A) receptors"Cardiovascular Drug Reviews. 15(2). 101-121 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Imokawa, S., et al.: "Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis"American Journal of Respiratory & Critical Care Medicine. 156(2Pt1). 631-636 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi, H., et al.: "Effects of nicotine and foot-shock stress on dopamine release in the striatum and nucleus accumbens"Brain Res. Bull.. 45. 157-162 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takada, Y., et al.: "Increased serotonergic activities inhibit feedings and cause arousal responses in rats"Biogenic Amines. 14(1). 67-77 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi, H., et al.: "Nicotine increases stress-induced serotonin release by stimulation nicotinic acetylcholine receptor in striatum"Synapse. 28. 212-219 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakata, K., et al.: "Remnant-like particle chloesterol is a major risk factor for myocardial infarction in vasospastic angina with nearly normal coronary artery"Atherosclerosis. 136. 225-231 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Aoki, N., et al.: "Severe heart stroke associated with high plasma levels of plasminogen activator inhibitor 1"Burns. 24. 74-77 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagai, N., et al.: "Reperfusion after venous occlusion caused transient increase in plasminogen activator inhibitor-1 in systemic circulation"Clinical and Applied Thrombosis/Hemostasis. 4(2). 133-137 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi, H., et al.: "Extracellular serotonin in the striatum increased after immobilization stress only in the nighttime"Behave. Brain Res.. 91. 185-191 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takada, Y., et al.: "Effects of electric footshock and water immersion restraint stresses on fibrinolytic parameters in the plasma of rats"Thromb. Res.. 89. 107-114 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Endo, A., et al.: "Proteolysis of highly polysialylated NCAM by the tissue plasminogen activator-plasmin system in rats"Neuroscience Letters. 246. 37-40 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi, H., et al.: "Hyperfibrinolytic Activity After Head Injury Is Induced By Elevated tPA Activity"Fibrinolysis and Proteolysis. 12(2). 113-116 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Urano, T., et al.: "Human thrombin and calcium bound factor xa significantly shortern tPA-induced fibrin clot lysis time via neutralization of plasminogen activator inhibitor type 1 activity"Thrombosis and Haemostasis. 80. 161-166 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Krupinski, K., et al.: "Dermatan sulfate enhances the lysis of laser-induced thrombus in vivo"Thromb. Res.. 91. 199-202 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Morita, S., et al.: "Cancer cells overexpress mRNA of urokinase-type plasminogen activator, its receptor and inhibitor in human non-small-cell lung cancer tissue"Int. J. Cancer. 78. 286-292 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakata, K., et al.: "Remnant-like particle cholesterol in coronary artery disease : correlation with plasminogen activator inhibitor-1 activity"Fibrinolysis & Proteolysis. 12(3). 123-127 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi, H., et al.: "Progressive expansion of hypertensive intracerebral hemorrhage by coaulopathy"Am. J. Hematology. 59. 110-114 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Teramoto, Y., et al.: "Plasma levels of 5-HT and 5-HIAA increased after intestinal ischemia/reperfuion in rats"Jap. J. Physiol.. 48(5). 333-339 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Pawlak, D., et al.: "Vascular and cardiac effects of DV 7028, a selective 5-HT2 receptor antagonist in rats"J. Cardiovasc. Pharmacol.. 32. 266-273 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Endo, A., et al.: "Proteolysis of neuronal cell adhesion molecule by the tissue plasminogen activator-plasmin system after kainate injection in the mouse hippocampus"Neurosci. Res.. 33. 1-8 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Malyszko, J. S., et al.: "15-deoxypergualin and platelet aggregation in vitro"Nephron. 81. 370-372 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takada, A., and Takada, Y.: "Cancer and fibrinolysis"Turk. J. Haematol.. 16(2). 51-64 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagai, H. et al.: "Nouronal degeneration and a decrease in laminin-like immunoreactivity is associated with elevated tissue-type plasminogen activator in the rat hippocampus after kainic acid injection"Neurosci. Res.. 33. 147-154 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakata, K., et al.: "Differential effects of enelapril and nitrendipine on the fibrinolytic system in essential hypertension"Am. Heart J.. 137(6). 1094-1099 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Endo, A., et al.: "The activation of the tissue plasminogen activator-plasmin system induced in the mouse hippocampus after injection of trimethyltin : Possible proteolysis of highly polysialated NCAM"Jpn. J. Physiol.. 49. 463-466 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ahaneku, J. E. et al.: "Influence of baseline values on lipids, lipoproteins and fibrinolytic parameters during amlodipine treatment of hypertension in Japanese patients"Pharmacol. Res.. 41(1). 75-79 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ahaheku, J. E. et al.: "Influence4 of baseline values on lipids, lipoproteins and fibrinolytic parameters during treatment of hypertension with clinidipine"Pharmacol. Res.. 41(1). 81-84 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Abe. J. et al.: "Larger and more invasive colorectal carcinoma contains larger amounts of plasminogen activator inhibitor type 1 and its relative ratio over urokinase receptor correlates well with tumor size"Cancer. 86(12). 2602-2611 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Urano, T., et al.: "Coagulation Associated Enhancement of Fibrinolytic Activity Via a Neutralization of PAI-1 Activity"Semin. Thromb. Hemost.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Urano, T., et al.: "The cleavage and inactivation of plaxminogen activator inhibitor type 1 and α2-antiplasmin by reptilase, thrombin-like venom enzyme"Blood Coagulation & Fibrinolysis. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Pawlak, R., et al.: "Differential effects of nicotine against stress-induced changes in dopaminergic system in rat striatum and hippocampus"Eur. J. Pharamacol.. 387. 171-177 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Urano, T., et al.: "Soluble thrombomodulin quenches thrombin-mediated neutralization of PAI-1 activity and inhibits fibrinolysis through a TAFI independent mechanism"Fibrinolysis & Proteolysis. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takada, Y., Takahashi , H., Ihara, H., Urano, T. and Takada, A.: "Effects of nicotine on serotonergic systems of brain and blood of rats exposed to footshock"Biog. Amines. 13 (1). 67-78 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi , H., Urano, T. Takada, Y., Nagai, N. and Takada, A.: "Fibrinolytic parameters as an admission prognostic marker of head injury in patients who talk and deteriorate"J. Neurosurg.. 86. 768-772 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakano, T. Knofler, R. Nakajima, K. Takada, Y. and Takada, A.: "Remnant-like particle stimulate platelet aggregation in whole blood. Atherosclerosis IV : Recent Advances in Atherosclerosis Research"Ann. N. Y. Acad, Sci.. 811. 480-487 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Urano, T., Nishikawa, T., Nagai, N., Takada, Y. and Takada, A.: "Amounts of tPA and PAI-1 in the euglobulin fraction obtained at different pH : their relation to the euglobulin clot lysis time"Thromb. Res.. 88 (1). 75-80 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Rydzewski, A., Urano, T., Nagai, N., Takada, Y. Katoh-Oishi, Y., Taminato, T., Yoshimi, T. and Takada, A.: "Diurnal variation in serum remnant-like lipoproteins, platelet aggregation and fibrionolysis in healthy volunteers."Haemostasis. 27. 305-314 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Malyszko, J., Pawlak, D., Mysliwiec, M., Takada, Y. and Takada, A.: "DV-7028, a novel selective serotonin (5-HT)2 receptor antagonist, and katenserin influence normal and uremic platelet aggregation in vitro"J. Serotonin Res.. 4. 223-232 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takada, Y., Takada, A. and Urano, T.: "MCI-9042, the new selective antagonist of serotonergic (5-HT2A) receptors"Cardiovascular Drug Reviews. 15 (2). 101-121 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Imokawa, S., Sato, A., Hayakawa, H., Kotani, M., Urano, T. Takada, A.: "Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis"Am. J. Respiratory & Critical Care Medicine. 156 (2Pt1). 631-636 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi , H., Takada, Y., Nagai, N., Urano, T. and Takada, A.: "Effects of nicotine and footshock stress on dopamine release in the striatum and necleus accumbens"Brain Res. Bull.. 45. 157-162 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takada, Y., Nagai, N., Takahashi , H., Urano, T. and Takada, A.: "Increased serotonergic activities inhibit feedings and cause arousal responses in rats"Biogenic Amines. 14 (1). 67-77 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi , H., Takada, Y., Nagai, N., Urano, T. and Takada, A.: "Nicotine increases stress-induced serotonin release by stimulating nicotinic acetylcholine receptor in rat striatum"Synapse. 28. 212-219 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakata, K., Miho, H., Shirotani, M., Yoshida, H., Takada, Y. and Takada, A.: "Remnant-like particle cholesterol is major risk factor for myocardial infarction in vasospastic angina with nearly normal coronary artery"Atherosclerosis. 136. 225-231 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Aoki, N., Yoshino, A., Ueda, Y., Urano, T. and Takada, A.: "Severe heart stroke associated with high plasma levels of plasminogen activator inhibitor 1"Burns. 24. 74-77 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagai, N., Urano, T., Takada, Y. and Takada, A.: "Reperfusion after venous occlusion caused transient increase in plasminogen activator inhibitor-1 in systemic circulation"Clin. Appl. Thrombosis/Hemostais. 4 (2). 133-137 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi, H., Takada, Y., Nagai, N., Urano, T., and Takada, A.: "Extracellular serotonin in the striatum increased after immobilization stress only in the nighttime"Behav. Brain Res.. 91. 185-191 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takada, Y., Urano, T., Takahashi, H., Nagai, N. and Takada, A.: "Effects of electric footshock and water immersion restraint stresses on fibrinolytic parameters in the plasma of rats"Thromb. Res.. 89. 107-114 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Endo, A., Nagai, N., Urano, T., Ihara, H., Takada, Y., Hashimoto, K. and Takada, A.: "Proteolysis of highly polysialated NCAM by the tissue plasminoge activator-plasmin system in rats"Neurosci. Lett.. 246. 37-40 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi, H., Urano, T., Nagai, N., Takada, Y. and Takada, A.: "Hyperfibrinolytic activity after head injury is induced by elevated tPA activity"Fibrinolysis & Proteolysis. 12 (2). 113-116 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Urano, T., Nagai, N., Matsuura, M., Ihara, H., Takada, Y. and Takada, A.: "Human thrombin and calcium bound factor Xa significantly shorten tPA-induced fibrin clot lysis time via neutralization of plasminogen activator inhibitor type 1 activity"Thromb. Haemost.. 80. 161-166 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Krupinski, K., Bielawiec, M., Yoshida, K., Kyogashima, M., Takada, Y. and Takada, A.: "Dermatan Sulfate enhances the lysis of laser-induced thrombus in vivo."Thromb. Res.. 91. 199-202 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Morita, S., Sato, A., Hayakawa, H., Ihara, H., Urano, T., Takada, Y. and Takada, A.: "Cancer cells overexpress mRNA or urokinase-type plasminogen activator, its receptor and inhibitors in human non-small cell lung cancer tissue : analysis by northern blotting and in situ hybridization"Int. J. Cancer. 78. 286-292 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakata, K., Miho, N., Ohtani, S., Shirotani, M., Yoshida, H. and Takada, A.: "Remnant-like particle cholesterol in coronary artery disease : correlation with plasminogen activator inhibitor-1 activity"Fibrinolysis & Proteolysis. 12 (3). 123-127 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi, H., Urano, T., Nagai, N., Takada, Y. and Takada, A.: "Progressive expansion of hypertensive intracerebral hemorrhage by coagulopathy"Am. J. Hematol.. 59. 110-114 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Teramoto, Y., Urano, T., Nagai, N., Takada, Y. and Takada, A.: "Plasma levels of 5-HT and 5-HIAA increased after intestinal ischemia/reperfusion in rats"Jpn. J. Physiol.. 48 (5). 333-339 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Pawlak, D., Adamkiewicz, M., Malyszko, J., Takada, A., Mysliwiec, M. and Buczko, W.: "Vascular and cardiac effects of DV 7028, a selective 5-HT2 receptor antagonist in rats"J. Cardiovasc. Phamacol.. 32. 266-273 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Endo. A., Nagai, N., Urano, T., Takada, Y., Hashimoto, K., and Takada, A.: "Proteolysis of neuronal cell adhesion molecule by the tissue plasminogen activator-plasmin system after kainate injection in the mouse hippocampus"Neurosci. Res.. 33. 1-8 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Malyszko, J.S., Malyszko, J., Mysliwiec, M. and Takada, A.: "15-deoxypergualin and platelet aggregation in vitro"Nephron. 81. 370-372 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takada, A. and Takada, Y.: "Cancer and fibrinolysis"Turk, J. Haematol.. 16(2). 51-64 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagai, N., Urano, T., Endo, A., Takahashi, H., Takada, Y. and Takada, A.: "Neuronal degeneration and a decrease in laminin-like immunoreactivity is associated with elevated tissue-type plasminogen activator in the rat hippocampus after kainic acid injection"Neurosci. Res.. 33. 147-154 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakata, K., Shirotani, M., Yoshida, H., Urano, T., Takada, Y. and Takada, A.: "Differential effects of enalapril and nitrendipine on the fibrinolytic system in essential hypertension"Am. Heart J.. 137(6). 1094-1099 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Endo, A., Hashimoto, K., Takada, Y. and Takada, A.: "The activation of the tissue plasminogen activator-plasmin system induced in the mouse hippocampus after injection of trimethyltin : Possible proteolysis of highly polysialated NCAM"Jpn. J. Physiol.. 49. 463-466 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ahaneku, J.E., Sakata, K., Urano, T., Takada, Y. and Takada, A.: "Influence of baseline values on lipids, lipoproteins and fibrinolytic parameters during amlodipine treatment of hypertension in Japanese patients"Pharmacol. Res.. 41(1). 75-79 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ahaneku, J.E., Sakata, K., Urano, T., Takada, Y. and Takada, A.: "Influence of baseline values on lipids, lipoproteins and fibrinolytic parameters during treatment of hypertension with clinidipine"Pharmacol. Res.. 41(1). 81-84 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Abe, J., Urano, T., Konno, H., Erhan, Y., Tanaka, T., Nishino, N., Takada, A., Nakamura, S.: "Larger and More Invasive Colorectal Carcinoma Contains Larger Amounts of Plasminogen Activator Inhibitor Type 1 and Its Relative Ratio over Urokinase Receptor Correlates Well with Tumor Size"Cancer. 86(12). 2602-2611 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Urano, T., Ihara, H., Suzuki, Y., Takada, Y. and Takada A.: "Coagulation Associated Enhancement of Fibrinolytic Activity Via a Neutralization of PAI-1 Activity."Semin. Thromb. Hemost.. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Urano, T., Ihara, H., Takada, Y., Fujie, M. and Takada, A.: "The cleavage and inactivation of plasminogen activator inhibitor type 1 and a2-antiplasmin by reptilase, a thrombin-like venom enzyme"Blood Coagulation & Fibrinolysis. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Pawlak, R., Takada, Y., Takahashi, H., Urano, T., Ihara, H., Nagai, N. and Takada, A.: "Differential effects of nicotine against stress-induced changes in dopaminergic system in rat striatum and hippocampus"Eur. J. Pharmacol.. 387. 171-177 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Urano, T., Ihara, H., Suzuki, Y., Nagai, N., Takada, Y. and Takada, A.: "Soluble thrombomodulin quenches thrombin-mediated neutralization of PAI-1 activity and inhibits fibrinolysis through a TAFI independent mechanism"Fibrinolysis & Proteolysis. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Endo A,et al: "Proteolysis of neuronal cell adhesion molecule by the tissue plasminogen activator-plasmin system after kainate injection in the mouse hippcocampus"Neurosci,Res.. 33. 1-8 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Malyszko,J,S.,et al: "15-deoxypegualin and platelet aggregation in vitro"Nephron. 81. 370-372 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takada,A.and Takada,Y.: "Cancer and Fibrinolysis"Turk,J.Haematol.. 16(2). 51-64 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagai,N.et al: "Neuronal degeneration and a decrease in laminin-like immunoreactivity in assocciated with elevated tissue-type plasminogen activator in the rat hippocampus after kainic acid injection"Neurosci,Res.. 33. 147-154 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sakata,K.et al: "Differential effects of enalapril and nitrendipine on the fibrinolytic system in essential hypertension"Am.Heart J.. 137(6). 1094-1099 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Endo,A.et al: "The activation of tissue plasminogen activator-plasmin system induced in the mouse hippocampus after injection of trimethyltin : Possible proteolysis of highly polysialated NCAM"Jpn,J.Physiol.. 49. 463-466 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Abe,J.et al: "Larger and more invasive colorectal carcinoma conatains larger amounts of plasminogen activator inhibitor type I and its relative ratio over urokinase receptor correlates well with tumor size"Cancer. 86(12). 2602-2611 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Pawlak,R.et al: "Differential effects of nicotine against stress-induced changes in dopaminergic system in rat striatum and hippocampus"Eur,J.Pharamacol.. 387. 171-177 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ahaneku,J.E.et al: "Influence of baseline values on lipids,lipoproteins and fibrinolytic parameters during amlodipine treatment of hypertension in Japanese patients"Phamacol,Res.. 41(1). 79-82 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ahaneku,J.E.et al: "Influence4 of baseline values on lipids,lipoproteins and fibrinolytic parameners during treatment of hypertension with clinidipine"Phamacol,Res.. 41(1). 73-77 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Urano,T.et al: "Coagulation Associated Enhancement of Fibrinolytic Activity Via a Neutralization of PAI-1 Activity"Semin.Thromb.Hemost.. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Urano,T.et al: "The cleavage and inactivation of plasminogen activator inhibitor type 1 and α2-antiplasmin by reptilase,a thrombin-like venom enzyme"Blood Coagulation & Fibrinolysis. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Urano,T.et al: "Soluble therombomodulin quenches thrombin-mediated neutralization of PAI-1 activity and inhibits fibrinolysis through a TAF1 independent mechanism"Fibrinolysis & Proteolysis. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Urano,T.,et al.: "Human thrombin and calcium bound factor xa significantly shorten tPA-induced fibrin clot lysis time via neutralization of plasminogen activator inhibitor type 1 activity." Thrombosis and Haemostasis. 80. 161-166 (1998)

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  • [Publications] Takahashi,H.,et al: "Hyperfibrinolytic Activity After Head Injury Is Induced By Elevated tPA Activity." Fibrinolysis and Proteolysis. 12(2). 113-118 (1998)

    • Related Report
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  • [Publications] Morita,S.,et al: "Cancer cells overexpress mRNA of urokinase-type plasminogen activator,its receptor and inhibitors in human non-small-cell lung cancer tissue." Int J Cancer. 78. 286-292 (1998)

    • Related Report
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  • [Publications] Takahashi,H.,et al: "Progressive expansion of hypertensive intracerebral hemorrhage by coagulopathy." Am.J.Hematology. 59. 110-114 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Endo,A.,et al: "Proteolysis of highly polysialylated NCAM by the tissue plasminogen activator-plasmin system in rats." Neuroscience Letters. 246. 37-40 (1998)

    • Related Report
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  • [Publications] Takada,Y.,et al: "Effects of electric footshock and water immersion restraint stresses on fibrinolytic parameters in the plasma of rats." Thromb.Res. 89. 107-114 (1998)

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  • [Publications] Teramoto,Y.,et al: "Plasma Levels of 5-HT and 5-HIAA increased after Intestinal Ischemia/Reperfusion in Rats." Jap.J.Physiol.48. 333-339 (1998)

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  • [Publications] Imokawa,S., et al: "Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic eclerosis." American Journal of Respiratory & Critical Care Medicine. 156(2). 631-636 (1997)

    • Related Report
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  • [Publications] Nagai,N., et al: "Reperfusion after venous occlusion caused transient increase in plasminogen activator inhibitor-1 in systemic circulation." Clinical and Applied Thrombosis/Hemostasis. (印刷中). (1997)

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  • [Publications] Urano,T., et al: "Amounts of tPA and PAI-1 in the euglobulin fraction obtained at different pH: Their relation to the euglobulin clot lysis time." Thrombosis Research. 88(1). 75-80 (1997)

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  • [Publications] Takada,Y., et al: "Effects of Nicotine on serotonergic systems of brain and blood of rats exposed to footshock." Biogenic Amines. 13(1). 67-78 (1997)

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  • [Publications] Takahashi,H., et al: "Fibrinolytic parameters as an admission prognostic marker of head injury in patients who talk and deteriorate." J.Neurosurgery. 86. 768-772 (1997)

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  • [Publications] Takada,Y., et al: "MCI-9042,the new selective antagonist of serotonergic(5-HT2A)receptors." Cardiovascular Drug Reviews. 15(2). 101-121 (1997)

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  • [Publications] Takahashi,H., et al: "Nicotine increases stress-induced serotonin release by stimulating nicotinic acetylcholine receptor in rat striatum." Synapse. (印刷中).

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      1997 Annual Research Report
  • [Publications] Takahashi,H., et al: "Extracellular serotonin in the striatum increased after immobilization stress only in the nighttime." Behave.Brain Res.(印刷中).

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  • [Publications] Takahashi,H.et al: "Effects of nicotine and foot-shock stress on dopamine release in the striatum and nucleus accumbens." Brain Res.Bull.45. 157-162 (1998)

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  • [Publications] Takada,Y., et al: "Increased serotonergic activities inhibit feedings and cause arousal responses in rats." Biogenic Amines. (印刷中).

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Published: 1997-04-01   Modified: 2016-04-21  

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