| Project/Area Number |
09670070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nara Women's University |
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Principal Investigator |
MIKI Keniu Nara Women's University, Life Science & Human Technology, Professor, 生活環境学部, 教授 (80165985)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | oxygen consumption / energy metabolism / rat / sympathetic nerve activity / baroreflex / cardiopulmonary mechanoreceptors |
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| Research Abstract |
Regular exercise causes a decrease in body weight. The decrease in body weigh caused by exercise is attributed to the increase in energy expenditure and the increase in the mobilization of fat as the energy substrate. The mechanism underling the increase in fat mobilization for the energy production is poorly understood. The purpose of the present project is to study the role of sympathetic nerve activity in regulation substrate mobilization for the energy production. Following three series of experiments were performed to achieve this aim.
Effect of moderate tredmill exercise on sympathetic nerve activity and energy metabolism in Wistar rats were studied After cessation of treadmill exercise, renal sympathetic nerve activity decreased in a sustained fashion over 60 min whereas oxygen consumption returned to the pre-exercise level. The respiratory quotient decreased significantly relative to the pre-exercise level while oxygen consumption returned to the pre-exercise level. We speculate
… More
that the sustained reduction of RSNA observed after cessation of exercise might be partly responsible for the post-exercise increase in the oxidation of fat.
The purpose of the present study was to determine the effect of exercise on the baroreflex control of renal sympathetic nerve activity (RSNA). Systemic arterial pressure (Pa)-RSNA relationship was determined before, during and after treadmill exercise. The Pa-RSNA curve was shifted upward and to the right indicating an increase in the peak sensitivity by 110% (p<0.05) during exercise. The Pa-RSNA curve tended to shift downward and to the left with decreased peak sensitivity by 16% after cessation of exercise. These data indicate that exercise induces elevated arterial pressure by acutely resetting the baroreflex control of RSNA.Suppression of the Pa-RSNA relationship after exercise may be related to the post-exercise hypotension.
The potential role of cardiopulmonary mechanoreceptors for inducing the sustained increase in renal sympathetic nerve activity (RSNA) and concomitant reduction of sodium excretion occurring during 400 head-up tilt in intact dogs. Cardiac denervation attenuated the activation of RSNA and abolished antidiuretic and antinatriuretic responses to head-up tilt occurring in the intact dogs. Therefore, we concluded that the cardiopulmonary mechanoreceptors play a critical role in the RSNA during 400 head-up tilt in conscious dogs. Less
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