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Humoral-sympathetic interaction in the adaptive regulation of body-fluid balance under central salt loading : involvement of arterial baroreceptor and vasopressin.

Research Project

Project/Area Number 09670073
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionMiyazaki Medical College

Principal Investigator

KANNAN Hiroshi  Miyazaki Med.College, Dept.Physiol, Professor, 医学部, 教授 (00049058)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordssalt-sensitivity / renal sympathetic nerve activity / renal sodium excretion / vasopressin / cardiovascular regulation / rat / 脳室内投与 / アンタゴニスト / 腎臓交感神経活動 / 中枢ナトリウム / 浸透圧受容器 / ナトリウム・水分調節 / 最後野
Research Abstract

Various epidemiological studies have suggested a correlation of dietary salt intake with blood pressure regulation and the prevalence and progression of essential hypertension. However, the mechanisms responsible for the generation and maintenance of hypertension in response to salt loading remain to be elucidated. The present study, which was conducted using conscious freely moving rats, purported to test the hypothesis that failure of the renal sympathetic nerve activity (RSNA) response to salt loading participates in impaired renal sodium excretion, leading to hypertension.
(1) Intracerebroventricular (i.c.v.) administration of hypertonic saline (0.3, 0.67, and 1.0 M, 1 mu1/min) elicited an inhibition accompanied with an increase in arterial blood pressure in a dose-related manner, while the heart rate did not change.
(2) In sinoaortic denervated (SAD) rats, the inhibition in RSNA to hypertonic NaCI was greatly attenuated, but still significantly persisted, compared to the control lev … More el.
(3) Pretreatment with vasopressin V_1, but not with a V_2-receptor non-peptide antagonist, attenuated hypertonic NaCI-induced inhibition in RSNA in intact rats but did not further affect the inhibition in SAD rats. This finding suggests the involvement of arterial baroreceptor inputs in the vasopressin-induced inhibition in RSNA.
(4) To elucidate the mechanisms responsible for the modulation of RSNA response by endogenous vasopressin to salt loading, Fos-like immunoreactivity (FLI) induced by the central infusion of hypertonic NaCI was measured in the subfornical organ (SF0), the organum vasculosum of the lamina terminalis (OVLT), the area postrema (AP), the hypothalamic paraventricular nucleus (PUN), and the supraoptic nucleus (SON). Central infusion of hypertonic NaCI increased FLI in OVLT, PVN, SON, and AP, but not in SF0 , in a tonicity-dependent manner. Pretreatment with AVP V1-receptor antagonist significantly increased FLI in the PVN and decreased FLl in the AP, while other regions did not change. The finding suggests the existence of a "feedback" modulatory loop activated by vasopressin through the PVN and AP on the RSNA outflow to central salt loading. Less

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Kato, K.: "Difference in water intake but not in renal sympathetic nerve activity in response to central salt-loading or angiotensin II in awake Dahl salt-sensitive and-resistant rats." Neurosc.Lett.242. 41-44 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koto, K.: "Participation of arterlal baroreceptors input and peripheral vasopressin in the suppression of renal sympathetic nerve activity induced by central salt loading in conscious rats." J.Auton.Nerv.Syst.in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishizuka, Y.: "Effects of area postrema lesion and abdominal vagotomy on interleukin-1β-induced norepinephrine release in the hypothalamic paraventricular nucleus region in the rat." Neurosci.Lett.223. 57-60 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kannan, H.: "Effects of systemic interleukin-1β administration on daily drinking and renal excretory function in conscious rats." Physiol.Behav.61. 707-715 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimokawa, A.: "Effects of anesthetics on norepinephrine release in the hypothalamic paraventricular nucleus region of awake rats." Neurosci.Lett.244. 21-24 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishizuka, Y.: "Abdominal vagotomy attenuates interleukin-1β-induced nitric oxide release in the paraventricular nucleus region in conscious rats." Brain Res.789. 157-161 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kato, K., Saita, M., Ishizuka, Y., Nose, K., Kunitake, T., Hanamori, T.& Kannan, H.: "Difference in water intake but not in renal sympathetic nerve activity in response to central salt-loading or angiotensin II in awake Dahl salt-sensitive and-resistant rats." Neurosci.Lett.242. 41-44 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kato, K., Shirasaka, T., Kunitake, T., Hanamori, T.& Kannan, H.: "Participation of arterial baroreceptors input and peripheral vasopressin in the suppression of renal sympathetic nerve activity induced by central salt loading in conscious rats." J.Auton.Nerv.Syst.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishizuka, Y., Ishida, Y., Kunitake, T., Kato, K., Hanamori, T., Mitsuyama, Y.& Kannan, H.: "Effects of area postrema lesion and abdominal vagotomy on interleukin-1beta-induced norepinephrine release in the hypothalamic paraventricular nucleus region in the rat." Neurosci.Lett.223. 57-60 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kannan, H., Iki, K., Ishizuka, Y., Kato, K., Shimokawa, A., Saita, M., Kunitake, T.& Hanamori, T.: "Effects of systemic interleukin-1beta administration on daily drinking and renal excretory function in conscious rats." Physiol.Behav.61. 707-715 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimokawa, A., Jin, Q.-H., Ishizuka, Y., Kunitake, T., Takasaki, M.& Kannan, H.: "Effects of anesthetics on norepinephrine release in the hypothalamic paraventricular nucleus region of awake rats." Neurosci.Lett.244. 21-24 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishizuka, Y., Ishida, Y., Jin, Q.-H., Shimokawa, A., Saita, M., Kato, K., Kunitake, T., Hanamori, T., Mitsuyama, Y.& Kannan, H.: "Abdominal vagotomy attenuates interleukin-1beta-induced nitric oxide release in the paraventricular nucleus region in conscious rats." Brain Res.789. 157-161 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Saita, M., Shimokawa, A., Kunitake, T., Kato, K., Hanamori, T., Kitamura, K., Eto, T & Kannan, H.: "Central actions of adrenomedullin on cardiovascular parameters and sympathetic outflow in conscious rats." Am.J Physiol.274. R979-R984 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimokawa, A., Kunitake, T., Takasaki, M.& Kannan, H.: "Differential effects of anesthetics on sympathetic nerve activity and arterial baroreceptor reflex in chronically instrumanted rats." J.Auton.Nerv.Syst.72. 46-54 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Saita, M., Ishizuka, Y., Kato, K., Kunitake, T., Hanamori, T., Kitamura, K., Eto, T.& Kannan, H.: "Cardiovascular and sympathetic effects of proadrenomedullin NH_2-terminal 20 paptide in conscious rats." Regul.Pept.77. 147-153 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Saita,M.et al.: "Central actions of adrenomedullin on cardiovascular parameters and sympathetic outflow in conscious rats." Am.J.Physiol.274. R979-R984 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shimokawa,A.et al.: "Differential effects of anesthetics on sympathetic nerve activity and arterial baroreceptor reflex in chronically instrumented rats." J.Auton.Nerv.Syst.72. 46-54 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Saita,M.et al.: "Cardiovascular and sympathetic effects of proadrenomedullin NH_2-terminal 20 peptide in conscious rats." Regul.Pept.77. 147-153 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kato,K.et al.: "Participation of arterial baroreceptors input and peripheral vasopressin in the suppression of renal sympathetic nerve activity induced by central salt loading in conscious rats." J.Auton.Nerv.Syst.(in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] lshizuka, Y. et al.: "Effects of area postrema lesion and abdominal vagotomy on interleukin-1B-induced norepinephrine release in the hypothalamic paraventricular nucleus region in the rat." Neurosci. Lett. 223. 57-60 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kannan, H. et al: "Effects of systemic interleukin-1β administration on daily drinking and renal excretory function in conscious rats." Physiol. Behav.61. 707-715 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hanamori, T. et al.: "Convergence of afferent inputs from the chorda tympani, lingual-tonsillar and pharyngeal branches of the glossopharyngeal nerve, and superior laryngeal nerve on the neurons in the insular cortex in rats." Brain Res.763. 267-270 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hanamori, T. et al.: "Convergence of oropharyngolaryngeal, baroreceptor and chemoreceptor afferents onto insular cortex neurons in rats." Chem. Senses. 22. 399-406 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Saita, M. et al.: "Central actions of adrenomedullin on cardiovascular parameters and sympathetic outflow in conscious rats." Am. J. Physiol.in press.

    • Related Report
      1997 Annual Research Report
  • [Publications] Kato,K.et al.: "Difference in water intake but not in renal sympathetic nerve activity in response to central salt-loading or angiotensin ll in awake Dahl salt-sensitive and-resistant rats." Neurosci.Lett.in press.

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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