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The effect of somatosensory stimulation on the blood flow in the skeletal muscle.

Research Project

Project/Area Number 09670084
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionTsukuba College of Technology

Principal Investigator

SATO Yuko  Department of Acupuncture/Moxibustion, Professor, 鍼灸学科, 教授 (10072985)

Co-Investigator(Kenkyū-buntansha) OHSAWA Hideo  Department of Acupuncture/Moxibustion, Assistant, 鍼灸学科, 助手 (40223789)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsskeletal muscle blood flow / muscle biceps femurs / laser Doppler flowmetry / somato-autonomic reflex / sympathetic nerve / CGRP / naloxone / blood pressure / α受容体 / β受容体 / ラット / 体性一自律神経反射 / 軸索反射 / CGRP受容体
Research Abstract

The effect of somatosensory stimulation on the blood flow in the muscle biceps femurs (MBF) was investigated by laser Doppler flowmetry in anesthetized artificially ventilated rat and we found the following results.
Result 1. Electro-acupuncture stimulation (EAS) applied to a hindpaw for 30 s at more than 1.5 mA which excited group III fibers almost maximally and was subthreshold for group IV fibers in saphenous nerve elicited small but significant increases of MBF. These responses were further increased at EAS at 2 mA or more, which was supra threshold for group IV fibers. EAS at 1.5 mA or more also elicited decrease of renal blood flow and presser responses. Following the severance of splanchnic nerves, the increased response of MBF reversed to the decreased response, which was abolished by further severance of lumbar sympathetic nerves. In conclusion, EAS to a hindpaw at a stimulus strength sufficient to excite group III and IV afferent fibers, can produce a reflex decrease in MBF via a reflex activation of muscle sympathetic activity, although this decrease in MBF is overridden by an increase in MBF caused passively by a presser response elicited by a reflex increase in splanchnic sympathetic activity.
Result 2. Antidromic repetitive electrical stimulation of unmyelinated dorsal roots at 3rd to 5th lumbar segments for 30 s caused an increase in MBF which was totally abolished by a topical application of a CGRP receptor antagonist.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Sato, A. et al: "The impact of somatosensory input on autonomic"Review of Physiology Biochemistry and Pharmacology. 130. 1-328 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ohsawa, H. et al: "Neural mechanism of pupillary dilation elicited by electro-acupuncture stimulation in anesthetized rats"Journal of the Autonomic Nervous System. 64・2-3. 101-106 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 鍵谷方子 ほか: "脊随後根の電気刺激が大腿二頭筋血流に及ぼす影響"自律神経. 35・2. 223 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Noguchi, E. et al: "The effect of electro-acupuncture stimulation on the muscle blood flow of the hindlimb in anesthetized rats"Journal of the Autonomic Nervous System. 75. 78-86 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 野口栄太郎 ほか: "鍼通電刺激によるラット骨格筋血流増加反応の神経性調節機構"自律神経. 36・1. 56-64 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sato, A. et al.: "Calcitonin gene-related peptide (CGRP) produced skeletal muscle vasodilation by antidromic stimulation of dorsal root afferents in rats"Nauroscience letters. in press. (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 大沢秀雄 ほか: "鍼灸最前線-科学化の現在と臨床の展開-"丹沢章八、尾崎昭弘、監修・編集、医道の日本社. 40-43 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sato, A. et al.: "The impact of somatosensory input on autonomic functions."Review of Physiology Biochemistry and Pharmacology. Vol. 130. 1-328 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ohsawa, H. et al.: "Neural mechanism of pupillary dilation elicited by electro-acupuncture stimulation in anesthetized rats."Journal of the Autonomic Nervous System. Vol. 64. 101-106 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Noguchi, E. et al.: "The effect of electro-acupuncture stimulation on the muscle blood flow of the hindlimb in anesthetized rats."Journal of the Autonomic Nervous System. Vol. 75. 78-86 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shimura, M. et al.: "Effect of natural mechanical stimulation on pupillary dilation in anesthetized rats."Neuroscience Letters. Vol. 259. 17-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mori, H. et al.: "Electro-acupuncture stimulation to a hindpaw and a hind leg produces different reflex responses in sympathoadrenal medullary function in anesthetized rats."Journal of the Autonomic Nervous System. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sato, A. et al.: "Calcitonin gene-related peptide (CGRP) produced skeletal muscle vasodilation by antidromic stimulation of dorsal root afferents in rats."Neuroscience letters. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 野口栄太郎 ほか: "麻酔ラットの皮膚・筋・腎血流に及ぼす体性感覚刺激の効果"第76回日本生理学会予稿集. 302 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 野口栄太郎 ほか: "鍼通電刺激によるラット骨格筋血流増加反応の神経性調節機構"自律神経. 36・1. 56-64 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 志村まゆら ほか: "鍼通電刺激で誘発される体性神経複合活動電位の特性"全日本鍼灸学会雑誌. 49・1. 203 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小林聰 ほか: "足三里への鍼通電刺激によって起こる循環反応"全日本鍼灸学会雑誌. 49・1. 206 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sato,A.et al.: "Calcitonin gene-related peptide (CGRP) produced skeletal muscle vasodilation by antidromic stimulation of dorsal root afferents in rats"Neuroscience letters. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakayama,H. et al.: "Effects of aging on numbers,sizes and conduction velocities of myelinated and unmyelinated fibers of the pelvic nerve in rats." J.Autonomic Nervous System. 69. 148-155 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 野口栄太郎ら: "麻酔ラット後肢筋血流に及ぼす鍼刺激の効果" 自律神経. 35(2). 232- (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 鍵谷方子ら: "脊髄神経の後根の電気刺激が大腿二頭筋血流に及ぼす影響" 自律神経. 35(2). 233- (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Simura,M.et al.: "Cutaneous afferents producing a reflex pupil dilation in anesthetized rats." Neuroscience Letters. 259. 17-20 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Noguchi,E.et al.: "The effect of electro-acupuncture stimulation on the muscle blood flow of the hindlimb in anesthetized rats." J.Autonomic Nervous System. 75. 78-86 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sato,A.et al.: "The impact of somatosensory input on autonomic functions." Reviews of Physiol.Biochem.Pharmacol.130. 1-328 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohsawa,H.et al.: "Neural mechanism of pupillary dilation elicited by electro-acupuncture stimulation in anesthetized rats." J.Autonomic Nervous System. 22. 101-106 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakayama,H.et al.: "Effects of aging on numbers,sizes and conduction velocities of myelinated and unmyelinated fibers of the pelvic nerve in rats." J.Autonomic Nervous System. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大沢 秀雄ら: "鍼灸最前線-科学化の現在と臨床の展開" 丹澤章八、尾崎昭弘、監修・編集、医道の日本社, 143 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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