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Study on modifying factors in the development of EBV-associated lymphomas

Research Project

Project/Area Number 09670184
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionOsaka University

Principal Investigator

AOZASA Katsuyuki (1998)  Osaka University Medical School, Professor, 医学部, 教授 (30115985)

大澤 政彦 (1997)  大阪大学, 医学部, 講師 (80213685)

Co-Investigator(Kenkyū-buntansha) KANNO Hiroyuki  Osaka University Medical School, Associate Professor, 医学部, 助教授 (40252663)
青笹 克之  大阪大学, 医学部, 教授 (30115985)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsEBV / nasal lymphoma / pyothorax-associated lymphoma / CTL / EBNA4 / EBNA4 / Poly morphic reticulosis / Epstein-Barr virus / Natural killer cell / Pathoepidemiological study / Denaturing grodient gell electrophoresis
Research Abstract

Nasal lymphoma(NL) and pyothorax-associated lymphoma(PAL) were the subjects in 1998.Results of the study on NL were as follows : (1) frequency of NL in the recent 10 years decreased to about 50% of the previous 15 years in Korea but slight decrease in Japan ; (2) combined immunophenotypic and genotypic studies showed that NL of lethal midline granuloma type is a neoplasia of natural killer(NK) cell.To elucidate the escape mechanism of EBV latent gene expressing PAL cells from host immune surveillance, CTL epitope of EBNA 4 regions was sequenced.The results showed mutations of the CTL epitope in 5 of 6 PAL cases examined, suggesting the mutations of EBV antigens contributed to development of PAL.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Hongyo T,Aozasa K,et al.: "Frequent P53 mutation at dipyrimidine sites in patients with pyothorax-associated lymphoma(PAL)" Cancer Research. 58. 1105-1107 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohsawa M,Aozasa K,et al.: "Hepatitis C viral genome in a subset of primary heptic lymphoma." Modern Pathology. 11. 471-478 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kanno H,Aozasa K,et al.: "Appearance of different clone of Epstein-Barr virus genome in...." Leukemia. 12. 1288-1294 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kojya S,Aozasa K,et al.: "Site specific localization of Epstein-Barr rvirus in the pharyngeal careinoma." Jpn J Cancer Res. 89. 510-515 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohsawa M,Aozasa K,et al.: "Risk of non-Hodgkin's lymphoma in patients with hepatitis C virus infection." International Journal of Cancer. 80. 237-239 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohsawa M,Aozasa K,et al.: "Immunophnotypic and genotypic characterization of nasal lymphoma." International Journal of Cancer. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hongyo T,Aozasa K,et al.: "Frequent p53 mutation at dipyrimidine sites in patients with pyothorax-associated lymphoma (PAL)" Cancer Research. 58. 1105-1107 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohsawa M,Aozasa K,et al.: "Hepatitis C viral genome in a subset of primary heptic lymphoma." Modern Pathology. 11. 471-478 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kanno H,Aozasa K,et al.: "Appearance of different clone of Epstein-Barr virus genome in" Leukemia. 12. 1288-1294 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kojya S,Aozasa K,et al.: "Site specific localization of Epstein-Barr virus in the pharyngeal carcinoma" Jpn J Cancer Res. 89. 510-515 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohsawa M,Aozasa K,et al.: "Risk of non-Hodgkin's lymphoma in patients with hepatitis C virus infection." International Journal of Cancer. 80. 237-239 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohsawa M,Aozasa K,et al.: "Immunophnotypic and genotypic characterization of nasal lymphoma" International Journal of Cancer. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hongyo T, Aozasa K, et al.: "Frequent p53 mutation at dipyrimidine sites in patients with pyothorax-associated lymphoma(PAL)" Cancer Research. 58. 1105-1107 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohsawa M, Aozasa K, et al: "Hepatitis C viral genome in a subset of primary heptic lymphoma." Modern Pathology. 11. 471-478 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kanno H, Aozasa,K, et al.: "Appearance of different clone of Epstein-Barr virus genome in --" Leukemia. 12. 1288-1294 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kojya S, Aozasa K, et al.: "Site specific localization of Epstein-Barr virus in the Pharyn-geal carcinoma." Jpn J Cancer Res. 89. 510-515 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohsawa M, Aozasa K, et al.: "Risk of non-Hodgkin's lymphoma in partients with hepatitis C virus infection." International Journal of Canser. 80. 237-239 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohsawa M, Aozasa K, et al.: "Immunophnotypic and genotypic characterization of nasal lymphoma" International Journal of Canser. in press.

    • Related Report
      1998 Annual Research Report
  • [Publications] Tomita Y, Ohsawa M, et: "Epstein-Barr virus in lymphoproliferative diseases in the sinonasal region." International Journal of Cancer. 70. 9-13 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Qui K, Ohsawa M, et al.: "Epatein-Barr virus in Gastric carcinoma : Association with histopathologic factors and HLA-Subtype." International Journal of Cancer. 71. 155-158 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hoshda Y, Ohsawa M, et al.: "Epstein-Barr virus in malignancies in renal transplant recipients in Japan." Journal Cancer Research Clinical Oncology. 123. 509-513 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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