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Intercellular recognition molecules controlling immune responses in parasitic infections

Research Project

Project/Area Number 09670273
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 寄生虫学(含医用動物学)
Research InstitutionJikei University School of Medicine

Principal Investigator

OHTOMO Hiroshi  Jikei University School of Medicine, Department of Tropical Medicine, Professor., 医学部, 教授 (80072916)

Co-Investigator(Kenkyū-buntansha) SAITO Saburo  Jikei University School of Medicine, Institute of DNA Medicine, Lecturer., 医学部, 講師 (10186934)
KATAKURA Ken  Jikei University School of Medicine, Department of Tropical Medicine, Lecturer., 医学部, 講師 (10130155)
WATANABE Naohiro  Jikei University School of Medicine, Department of Tropical Medicine, Professor., 医学部, 教授 (00057019)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1997: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsParasite infection / IgE / Eosinophil / Nippostrongylus / Hymenolepis / Strongyloides / Intercellular recognition molecule / T cell activation / 寄生虫感染 / 免疫療法
Research Abstract

The objective of this study is to identify costimulatory molecules engaging in the functional differentiation of T cells for characteristic immune responses and protective immunity in parasitic infections. The experiments were carried out in mice with special attention to CD8O and CD86 as costimulatory molecules.
IgE production and eosinophilia after primary infection with Nippostrongylus were normally induced by signal through either CD8O or CD86.These responses were suppressed by blockade of both molecules. In secondary IgE antibody production, CD86 could play as an important costimulatory signal but CD8O could not do. These results indicate participation of costimulatory signals on secondary response which has been considered to be little effect comparing with primary response. It has been demonstrated that the mechanism of expulsion of Nippostrongylus is different from that of Strongyloides. The involvement of CD8O and CD86 could not differentiate these mechanisms from the experimental results showing delay of expulsion in these helminths by blockade of both molecules. infection with eggs of Hymenolepis nana induced extremely strong protective immunity to secondary infection with eggs. It has been reported that the protective immunity to H.nana operates through delayed type hypersensitivity. However, the participation of CD8O and CD86 was found in the delayed type hypersensitivity but not in the protective immunity, suggesting separate mechanisms of these responses.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Nakajima, A.: "Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells." Int.Immunol.9. 637-644 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 渡辺直熙: "IgE抗体の産生調節機構" 医学のあゆみ. 180. 3-6 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Huang, Y.: "The Involvement of CD80 and CD86 Costimulatory Molecules in the Induction of Eosinophilia in Mice Infected with Nipponstrongylus brasiliensis." Int.Arch.Allergy Immunol.117. 2-4 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takamoto, M.: "Eposinophilia, IgE production, and cytokine production by long T cells in surface CD4-deficient mutant mice infected with Toxocara canis." Immunol.95. 97-104 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Asano, K: "CD80 and CD86 on immune responses to Hymenolepos nana in mice." 9th.Int.Cong.Parasitol.1225-1227 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 渡辺直熙: "IgE抗体の産生機序" Prog.Med.18. 2795 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakajima, A.et al.: "Requirement of CD28-CD86 co-stimulation in the interaction between antigen-ptimed T helper type 2 and B cells." Int.Immunol.9. 637-644 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Huang, Y.et al.: "The Involvement of CD80 and CD86 costimulatory molecules in the induction of eosinophilia in mice infected with Nippostorongylus brasiliensis." Int.Arch.Allergy.Immunol.180. 3-6 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takamoto, M.et al.: "Eposinophilia, IgE production, and cytokine production by lung T cell in surface CD4-deficient mutant mice infected with Toxocara canis." Immunol.95. 97-104 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Asano, K.et al.: "CD80 and CD86 on immune responses to Hymenolepis nana in mice." 9th.Int.Cong.Parasitol.1225-1227. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Huang,Y.: "The Involvement of CD80 and CD86 Costimulatory Molecules in the Induction of Eosinophilia in Mice Infected with Nipponstrongylus brasiliensis." Int Arch Allergy Immunol. 117. 2-4 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takamoto,M.: "Eposinophilia IgE production,and cytokine production by ling T cells in surface CD4-deficient mutant mice infected with Toxocara canis." Immunol. 95. 97-104 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Asano,K.: "CD80 and CD86 on immune responses to Hymenolepos nana in mice." 9th Int Cong Parasitol. 1225-1227 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 渡辺直熙: "IgE抗体の産生機序" Prog Med. 18. 2795 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakajima,A.: "Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells." Int.Immuno1.9. 637-644 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 渡辺直熙: "IgE抗体の産生調節機構" 医学のあゆみ. 180. 3-6 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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