| Project/Area Number |
09670345
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | INSTITUTE OF LIFE SCIENCE,SOKA UNICERSITY |
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Principal Investigator |
NARIMATSU Hisashi INSTITUTE OF LIFE SCIENCE,SOKA UNIVERSITY,PROFESSOR, 生命科学研究所, 教授 (40129581)
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| Co-Investigator(Kenkyū-buntansha) |
KUDO Takashi INSTITUTE OF LIFE SCIENCE,SOKA UNIVERSITY,INSTRUCTOR, 生命科学研究所, 助手 (20288062)
NISHIHARA Shoko INSTITUTE OF LIFE SCIENCE,SOKA UNIVERSITY,ASSOCIATE PROFESSOR., 生命科学研究所, 助教授 (00164575)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1997: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | GLYCOSYLTRANSFERASE / FUCOSYLTRANSFERASE / SELECTIN / CANCER / GALACTOSYLTRANSFERASE / LEWIS ANTIGEN / CARBOHYDRATE / CA19-9 |
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| Research Abstract |
We searched and identified for new members of glycosyltransferases involved in the synthesis of Lewis antigens which are the ligands for selectins. Successfully, we have cloned two novel genes encoding new glycosyltransferases, and named Fuc-TIX and beta3Gal-T5. Fuc-TIX was mainly expressed in brain and kidney, and participated in the synthesis of CD15 (Le^x) antigens. beta3Gal-T5 was found to be responsible for the synthesis of type 1 Lewis antigens, such as Le^a, Le^b and sLe^a. In particular, B3GaI-T5 was proven to be a responsible enzyme for the synthesis of CA 19-9 (sLe^a) antigen in gastrointestinal tissues. CA 19-9 is a very famous tumor marker, and its carbohydrate structure is defined as sLe^a which is the selectin ligand.
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