| Project/Area Number |
09670359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Osaka University |
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Principal Investigator |
TAKESHITA Tatsuya Osaka Univ. Grad. Sch. Of Med. Assoc. Prof., 医学部, 助教授 (20150310)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Soichiro Osaka Univ. Grad. Sch. Of Med. Assist. Prof., 医学部, 助手 (70219567)
TAKEUCHI Toru Osaka Univ. Grad. Sch. Of Med. Lecturer, 医学部, 助教授 (00188161)
MORIMOTO Kanehisa Osaka Univ. Grad. Sch. Of Med. Prof., 医学部, 教授 (20143414)
EZOE Satoko Osaka Univ. Grad. Sch. Of Med. Assist. Prof., 医学部, 助手 (40232954)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | alcohol drinking / genetic polymorphism / aldehyde dehydrogenase / acetaldehyde / hemoglobin / biomarker / アルコール / 遺伝子型 / 多型 / ライフスタイル |
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| Research Abstract |
Alcohol drinking have both harmful and preventive effects on health status. Ingested ethanol is converted in liver to very reactive metabolite, acetaldehyde, which can readily react with proteins and DNA, resulting in numerous responses. Those with the atypical ALDH2 genotype would be a good model to observe the effects of acetaldehyde since they have higher concentrations of acetaldehyde when they drink moderate amounts of alcohol. In the present studies, we have developed methods to sensitively measure acetaldehyde reversibly bound to hemoglobin (HbAA) in red blood cells in healthy subjects. We observed, among adult workers, a good correlations of the HbAA levels with the amounts of alcohol intake in the last two days, especially in the atypical ALDH2 genotype. Furthermore, we also found that this HbAA levels gradually increase when those with the atypical ALDH2 genotype drink moderate amounts of ethanol for 7 consecutive days. The results indicate that acetaldehyde would accumulate in the target tissues as reversible adducts to proteins in a similar way as in red blood cells. The HbAA levels would be one of useful biomarkers for evaluating and predicting consequences of alcohol drinking in each individual.
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