| Project/Area Number |
09670363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | JICHI MEDICAL SCHOOL |
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Principal Investigator |
KAYAMA Fujio DEPARTMENT OF ENVIRONMENTAL HEALTH,ASSOCIATE PROFESSOR, 衛生学, 助教授 (50177614)
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| Project Period (FY) |
1997 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | ENVIRONMENTAL HORMONES / ENDOCRINE DISRUPTERS / ESTROGEN RECEPTOR / PHYTOESTROGEN / YEAST / MCF-7 / HUMAN NORMAL EPIDERMAL KERATINOCYTES / AUTOANTIBODY / エストロフェン・レセプター / 植物エストロジェン / 内分泌撹乱化学物質 / 免疫 / エストロジェン / 環境汚染物質 |
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| Research Abstract |
TO ESTABLISH SCREENING SYSTEM IN ASSESSING ENDOCRINE DISRUPTING CHEMICALS, WE HAVE ASSESSED WELL-KNOWN ENDOCRINE DISRUPTERS BY USING BOTH HUMAN ESTROGEN RECEPTOR-INDUCED YEAST AND HUMAN BREAST CANCER CELL LINE (MCF-7)., AND COMPARED SENSITIVITY OF THESE ASSAY SYSTEMS.WE HAVE OBSERVED MCF-7 CELL ASSAY SYSTEM IS MORE SENSITIVE THAN YEAST-BASED ASSAY SYSTEM.
ADDITIONALLY, ADDITION OF ENDOCRINE DISRUPTERS, SUCH AS METHOXYCHLOR, 0CTYLPHENOL, AND BISPHENOL A, INDUCED AUTOANTIBODY AGAINST SS-AIRo IN NORMAL HUMAN EPIDERMAL KERATINOCYTES.THIS OBSERVATION IMPLY THE RELATIONSHIP BETWEEN AUTOIMMUNE DISEASES AND ENViRONMENTAL ENDOCRINE DISRUPTERS.
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